
微生物组领域主要研究栖息在不同环境中的复杂微生物群落,特别是宿主生物体内的微生物群落,以及它们的集体基因组。该领域整合了元基因组学、微生物 生态学, 以及宿主与微生物之间的相互作用,以阐明微生物的多样性、功能潜力以及影响健康、疾病和环境过程的动态。研究范围包括微生物定植、菌群失调、代谢物产生,以及通过益生菌和移植等干预措施调节微生物组。以下文集介绍了最新的科学出版物和专利创新,这些出版物和创新推动了人们对微生物群落结构、功能以及在医学、农业和生物技术领域应用的了解:
微生物组-肠-脑轴、微生物定植、微生物组图谱、微生物群落结构、微生物组-宿主协同进化、微生物基因表达、微生物组生物标志物、微生物组数据分析、微生物、微生物组稳定性、微生物菌群失调、微生物功能潜力、微生物组、微生物相互作用和微生物组生物地理学。.
Compositions and methods for treating microbial infections
Patent published on the 2026-05-21 in WO under Ref WO2026107208 by METHODIST HOSPITAL [US] (Tharmalingam Nagendran [us], Mylonakis Eleftherios [us])
Abstract: Described are analogs of aztreonam and disulfiram of Formula I, II, and III. These compounds can be used to treat bacterial infections in a subject. Also disclosed is the use of aztreonam and disulfiram for treating H. pylori infections. Combinations of the disclosed analogs and/or aztreonam and disulfiram with additional antibiotics and proton pump inhibitors are also disclosed.[...]
Our summary: The document discusses compositions and methods for treating microbial infections using analogs of aztreonam and disulfiram. These compounds are effective against bacterial infections, including H. pylori. Combinations with other antibiotics and proton pump inhibitors are also explored.
antibiotics, aztreonam, disulfiram, H. pylori
Patent
Aspergillus tubingensis, microbial agent, biomass fermentation product, and preparation and use thereof
Patent published on the 2026-05-21 in WO under Ref WO2026103717 by ANGEL YEAST CO LTD [CN] (Qin Xianwu [cn], Sun Yafang [cn], Xiao Yafei [cn], Zhang Yan [cn], Guo Tianfen [cn])
Abstract: Provided are a strain of Aspergillus tubingensis AMCC 20011, a microbial agent containing the strain and a preparation method therefor, a fermentation culture product of the strain and a preparation method therefor, and use of the strain or the microbial agent. The strain is deposited in the China Center for Type Culture Collection (CCTCC) with a deposit number of CCTCC NO: M 20241203. The strain has the ability to produce cellulase, β-glucosidase, and xylanase, has the characteristic of saccha[...]
Our summary: The content describes a strain of Aspergillus tubingensis AMCC 20011 and its use as a microbial agent. It details the strain s ability to produce cellulase, β-glucosidase, and xylanase while enhancing protein content in biomass. Additionally, it includes preparation methods for the strain and its fermentation culture product.
Aspergillus tubingensis, microbial agent, biomass fermentation, cellulase production
Patent
Low energy process for transesterification of extracted lipids from microbial degradation of plastic
Patent published on the 2026-05-21 in US under Ref US20260139281 by BATTELLE MEMORIAL INSTITUTE [US] (Garbark Daniel B [us], Cafmeyer Jeffrey T [us], Lilly Jacob [us])
Abstract: The invention provides a method and system for the enzymatic transesterification of fatty acids or fatty acid derived products to produce lubricant esters. The process involves a reaction mixture containing a fatty acid or fatty acid-derived substrate, an alcohol and a lipolytic enzyme catalyst. A reactive column with a porous frit is employed through which air is bubbled into a mixture of fatty acid derivatives, alcohol and an immobilized lipase catalyst. The air bubbles promote mixing and the [...]
Our summary: The invention describes a low energy method for enzymatic transesterification of fatty acids into lubricant esters. It utilizes a reaction mixture with air bubbling to enhance mixing and remove volatile by-products. This process achieves over 99 mol % conversion at ambient temperature, outperforming traditional thermochemical methods.
transesterification, enzymatic process, lipolytic enzyme, ambient temperature
Patent
Kluyveromyces marxianus strain, microbial agent, and preparation and use thereof
Patent published on the 2026-05-21 in WO under Ref WO2026103718 by ANGEL YEAST CO LTD [CN] (Sun Yafang [cn], Qin Xianwu [cn], Huang Yueyan [cn], Zhang Yan [cn], Lv Yang [cn], Zhang Xinyi [cn])
Abstract: The present invention belongs to the field of microorganisms, and specifically relates to a Kluyveromyces marxianus strain, a microbial agent, and preparation and use thereof. The Kluyveromyces marxianus strain comprises Kluyveromyces marxianus AMCC 31690 with a deposit number of CCTCC NO: M 2024246, Kluyveromyces marxianus AMCC 31691 with a deposit number of CCTCC NO: M 2024247, and Kluyveromyces marxianus AMCC 30630 with a deposit number of CCTCC NO: M 20222107. The described Kluyveromyces mar[...]
Our summary: The invention describes a specific Kluyveromyces marxianus strain with unique properties. It includes multiple strains with deposit numbers for identification. The strains exhibit resistance to various environmental stresses and maintain vitality in artificial digestive conditions.
Kluyveromyces marxianus, microbial agent, osmotic pressure resistance, acid resistance
Patent
Microbial fuel cell multiplexer apparatus, system and method
Patent published on the 2026-05-21 in US under Ref US20260142208 by US NAVY [US] (Bozeman Eric [us], Bond Matthew [us], Arias-thode Yolanda Meriah [us], Ramzi Halah [us], Lewis Taneka [us], Anderson Gregory [us])
Abstract: [0000] A microbial fuel cell multiplexer apparatus, system and method. In one embodiment, a microbial fuel cell (MFC) multiplexer, comprising a microcontroller suitable for receiving information from a MFC electronics unit and reformatting the information according to a communications protocol, and further comprising a processor and a non-transitory storage medium capable of storing machine-readable instructions; a host port connected to a host platform, wherein the host platform provides a powe[...]
Our summary: The microbial fuel cell multiplexer apparatus includes a microcontroller for processing data from MFCs. It features a host port for power and operations, along with isolator chips for MFC isolation. The design supports multiple unit ports for connecting various MFCs.
microbial fuel cell, multiplexer, microcontroller, isolator chips
Patent
Probiotic bacteria for fish
Patent published on the 2026-05-21 in US under Ref US20260137103 by PREVIWO AS [NO] (SØrum Henning [no])
Abstract: [0000] The present document is directed to probiotic bacteria and their use in fish farming for increasing the weight of fish and for treating and/or preventing a microbial infection of the fish. The bacteria are species within the Aliivibrio, Psychrobacter and Pseudomonas genera.[...]
Our summary: Probiotic bacteria enhance fish growth and prevent infections. They belong to the Aliivibrio, Psychrobacter, and Pseudomonas genera. Their application is significant in aquaculture practices.
Probiotic bacteria, fish farming, microbial infection, weight increase
Patent
Microplastic contamination and the benefits of blue flag beach status
Published on 2026-05-06 by @OXFORD
Abstract: AbstractThis study aimed to determine the effect of “Blue Flag” status, an award that reflects a strong dedication to the sustainable management and protection of coastal resources, on the level of microplastic (MP) in beach samples. Quantitative determination of MPs was carried out at two beach locations in Greece, a Blue Flag beach in Glyfada, Attica, and beaches of the remote island of Leros without Blue Flag status. Samples of surface sand sampled at a maximum depth of 3 cm were taken a[...]
Our summary: This study evaluates the impact of Blue Flag status on microplastic levels at beaches in Greece. Samples from a Blue Flag beach showed significantly lower microplastic contamination compared to non-Blue Flag beaches. The findings suggest that Blue Flag designation contributes to better beach management and environmental protection.
Microplastics, Blue Flag, beach management, environmental protection
Publication
Cloning and Characterization of GDSL Esterases from Bacillus paralicheniformis T7
Published on 2026-02-03 by Arman Mussakhmetov, Magzhan Astrakhanov, Dmitriy Silayev, Bekbolat Khassenov @MDPI
Abstract: Esterases catalyze the hydrolysis and transesterification of short-chain fatty acid esters, and microbial esterases are used in the production of biofuels, cosmetics, food, and pharmaceuticals. The soil strain Bacillus paralicheniformis T7 secretes enzymes with esterase activity; however, many bacterial enzymes remain insufficiently studied. Therefore, this study aimed to identify and characterize novel GDSL esterases produced by B. paralicheniformis. Protein mass spectrometry, combined with pro[...]
Our summary: This study identifies and characterizes novel GDSL esterases from Bacillus paralicheniformis T7. Two esterases were cloned and expressed in E. coli, showing optimal activity at 40 °C and pH 7.0. The strain demonstrates potential for biotechnological applications in degrading fatty acid esters.
GDSL esterases, Bacillus paralicheniformis, recombinant proteins, enzyme characterization
Publication