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生物信息学领域的最新出版物和专利

生物信息学出版物专利

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生物信息学
生物信息学结合了计算和统计技术,用于分析复杂的生物数据,以深入了解分子功能和疾病机制。

生物信息学整合了计算方法和统计技术,用于分析和解读生物数据,特别是大规模基因组、转录组、蛋白质组和代谢组数据集。该领域涵盖序列比对、基因组组装、基因表达谱分析、蛋白质结构预测和分子相互作用网络,从而有助于深入了解分子功能、进化关系和疾病机制。算法开发、机器学习应用和高通量数据处理的进步使得全面的注释、变异解读和系统级建模成为可能。以下合集汇集了最新的科学出版物和专利创新成果,重点关注计算工具、数据库管理、分析流程和整合方法,这些对于推进生物学研究和精准医学至关重要。

转录组学、元基因组学、蛋白质组学数据分析、分子对接、生物数据库、结构生物信息学、基因组注释、变异调用、表观基因组学、系统生物学、比较基因组学、功能基因组学、RNA-Seq 分析、生物统计学、计算生物学、生物标志物发现、通路分析和代谢组学。.

Regulatory nucleic acid molecules for enhancing gene expression in plants

Patent published on the 2026-06-04 in WO under Ref WO2026114881 by BASF SE [DE] (Meulewaeter Frank [be], Davis Erin [be])

Abstract: The current disclosure generally relates to the technical field of plant molecular biology and provides methods for the production of high expressing promoters and the production of plants with enhanced expression of nucleic acids wherein one or more nucleic acid expression enhancing nucleic acid (NEENA) is functionally linked to said promoters and/or introduced into plants.[...]


Our summary: This disclosure focuses on enhancing gene expression in plants using regulatory nucleic acid molecules. It details methods for producing high-expressing promoters. The approach involves linking nucleic acid expression enhancing nucleic acids to these promoters in plants.

nucleic acid, gene expression, plant molecular biology, promoters

Patent

Aptamer specifically binding to cell-derived extracellular vesicles and method for discovering extracellular vesicle-specific biomarker using same

Patent published on the 2026-06-04 in WO under Ref WO2026117034 by KONKUK UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION [KR] (Park Ki Soo [kr], Lee Eun Sung [kr], Jun Jimin [kr], Cha Byung Seok [kr], Kim Junhyeong [kr])

Abstract: The present invention relates to an aptamer specifically binding to cell-derived extracellular vesicles and a method for discovering an extracellular vesicle-specific biomarker using same. Specifically, the present invention relates to an aptamer specifically binding to cancer cell-derived extracellular vesicles, and a method for discovering an extracellular vesicle-specific biomarker using same. Unlike prior art requiring immobilization, a method for selecting an aptamer specifically binding to[...]


Our summary: The invention presents an aptamer that binds specifically to cancer cell-derived extracellular vesicles. It includes a method for discovering extracellular vesicle-specific biomarkers without immobilization, maintaining the three-dimensional structure. This approach facilitates novel biomarker discovery and target protein verification for diagnosis and drug development.

Aptamer, extracellular vesicles, biomarker discovery, cancer

Patent

Rhamnolipids for modified gene expression during wound healing

Patent published on the 2026-06-04 in WO under Ref WO2026117688 by STEPAN CO [US] (Strout Kelly [us], Savanhu Faith [us], Sanders Mitch [us])

Abstract: The technology presented herein, in general, relates to the use of biosurfactants, such as rhamnolipids, for treating and/or accelerating the healing of wounds. More particularly, the present technology relates to a method for treating chronic and acute wounds, by applying a composition comprising a mixture of rhamnolipids to the wound, wherein application of the composition facilitates coordinated gene expression associated with wound healing.[...]


Our summary: Rhamnolipids are used to enhance gene expression during wound healing. The method involves applying a rhamnolipid composition to wounds. This approach aims to treat both chronic and acute wounds effectively.

Rhamnolipids, biosurfactants, gene expression, wound healing

Patent

Prediction of stage and survival using isoform expression in gastric adenocarcinoma

Patent published on the 2026-06-04 in US under Ref US20260155253 by UNIV OF SOUTH FLORIDA [US] (Kuo Paul [us], Liang Yifan [us], Lien Kyle [us])

Abstract: Various processes, methods and systems are provided herein for assisting patients, medical providers and other personnel in predicting cancer stage and cancer survival. The systems and methods include determining an indication of a preliminary cancer diagnosis of a given type of cancer for a patient, receiving results of transcriptional sequencing analysis, extracting a set of isoform expression information from transcriptomic data, processing a cancer stemness isoform dataset for a patient, and[...]


Our summary: The content discusses methods for predicting cancer stage and survival in gastric adenocarcinoma using isoform expression. It involves analyzing transcriptional sequencing data and extracting relevant isoform information. The goal is to assist patients and medical providers in making informed decisions based on cancer diagnosis.

isoform expression, gastric adenocarcinoma, cancer prediction, transcriptomic data

Patent

Galnac oligonucleotide conjugate for inhibiting c5 gene expression

Patent published on the 2026-05-28 in WO under Ref WO2026108942 by CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD [CN] (Zhang Xueyan [cn], Wang Lingyu [cn], Su Xiaoye [cn], Zhao Chenglong [cn])

Abstract: Provided are an oligonucleotide conjugate comprising a GalNAc derivative, a pharmaceutical composition comprising the oligonucleotide conjugate, and use of the oligonucleotide conjugate or the pharmaceutical composition.[...]


Our summary: The content discusses a GalNAc oligonucleotide conjugate designed to inhibit C5 gene expression. It includes details about the conjugate, its pharmaceutical composition, and its applications. The focus is on the development and use of this therapeutic approach.

GalNAc, oligonucleotide, gene expression, pharmaceutical composition

Patent

Products and methods for full-length smchd1 expression using split inteins

Patent published on the 2026-05-21 in WO under Ref WO2026107323 by RESEARCH INST AT NATIONWIDE CHILDRENS HOSPITAL [US] (Harper Scott Q [us], Thangaraj Merlin Premalatha [us])

Abstract: Nucleic acids, vectors, compositions, systems, and methods for expressing a structural maintenance of chromosomes hinge domain containing 1 (SMCHD1) polypeptide to epigenetically silence double homeobox 4 (DUX4) for the treatment of a disease or disorder associated with DUX4 are provided. DUX4 regulates gene expression and plays a role in development, muscular dystrophy (including, but not limited to, facioscapulohumeral dystrophy (FSHD)), a cancer, or Bosma arhinia microphthalmia syndrome (BAMS[...]


Our summary: This content discusses products and methods for expressing the SMCHD1 polypeptide using split inteins. It highlights the role of DUX4 in diseases like muscular dystrophy and cancer. The approach aims to downregulate DUX4 expression for therapeutic purposes.

SMCHD1, split inteins, gene expression, DUX4

Patent

ReaxFF molecular dynamics investigation of co-combustion between Zhundong coal and lignin

Published on 2026-02-25 by @OXFORD

Abstract: AbstractCo-combustion of coal and biomass offers a promising solution to reduce fossil fuel dependency. This study employs reactive force-field molecular dynamics (ReaxFF MD) to investigate the microscopic effects of temperature and mixing ratio on Zhundong coal–lignin co-combustion. Elevated temperatures significantly enhance the conversion from large molecules to smaller gaseous products (CO2, H2O), suppressing tar formation. Higher coal ratios (3:1, 2:1) favor reduced tar yield and increase[...]


Our summary: This study uses ReaxFF molecular dynamics to analyze the co-combustion of Zhundong coal and lignin. Elevated temperatures and higher coal ratios improve gaseous product yields while reducing tar formation. Reaction pathways indicate distinct contributions from coal oxidation, lignin pyrolysis, and the behavior of nitrogen and sulfur during combustion.

ReaxFF, molecular dynamics, co-combustion, Zhundong coal

Publication

A Comparative Study of CNN, BiLSTM, and GRU Architectures

Published on 2026-02-03 by Elias Tabane, Ernest Mnkandla, Zenghui Wang @MDPI

Abstract: DNA sequence classification is a fundamental problem in bioinformatics, playing an indispensable role in gene annotation and disease prediction. Whereas most deep learning models, such as CNNs, BiLSTM networks, and GRUs, have been found individually optimal, each of these methods excels in modeling a specific aspect of sequence data: local motifs, long-range dependencies, and efficient temporal modeling of the sequences. Here, we present and evaluate an ensemble model that integrates CNN, BiLSTM[...]


Our summary: This study evaluates CNN, BiLSTM, and GRU architectures for DNA sequence classification. An ensemble model combining these methods achieved a classification accuracy of 90.6%, outperforming individual models. The research highlights the effectiveness of hybrid deep learning in genomic data analysis.

CNN, BiLSTM, GRU, ensemble

Publication

涵盖的主题: 生物信息学、计算技术、统计技术、生物数据、基因组数据集、转录组数据集、蛋白质组数据集、代谢组数据集、序列比对、基因组组装、基因表达谱分析、蛋白质结构预测、分子相互作用网络、机器学习、高通量数据处理、变异解释、系统级建模、精准医疗、ISO/IEC 27001、ISO 9001、ISO/IEC 25010、ISO 31000 和 ISO 13485。.

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