免疫学和疫苗学涵盖免疫系统功能的调控机制以及预防性和治疗性疫苗的研发。该领域整合了细胞和分子免疫学、抗原识别、免疫记忆以及宿主-病原体相互作用，旨在设计和优化疫苗制剂、佐剂和递送系统。研究方向包括免疫调节、免疫病理学以及提高疫苗对传染病、癌症和自身免疫性疾病疗效的策略。我们持续更新的汇编收录了最新的同行评审研究和专利信息。 技术 增进免疫学认识和疫苗创新：
免疫疗法、病原体识别受体、主要组织相容性复合体、免疫学、疫苗、免疫耐受、树突状细胞、体液免疫、细胞介导免疫、疫苗配方、减毒活疫苗、亚单位疫苗、粘膜免疫、免疫记忆、免疫检查点、疫苗佐剂、免疫病理学和免疫调节。.
Sorghum hybrid r20d2043
Patent published on the 2026-05-21 in US under Ref US20260137052 by PIONEER HI BRED INT (Mayor Maria Laura [us], Gifford Justin M [us])
Abstract: A novel sorghum variety designated R20D2043 and seed, plants, plant parts and plant cells thereof are produced from a cross of inbred sorghum varieties. Methods for producing a sorghum plant comprise crossing hybrid sorghum variety R20D2043 with another sorghum plant. Sorghum variety R20D2043, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of sorghum variety R20D2043 are provided. Methods for producing a sorghum plant containing in its genetic material[...]
Our summary: Sorghum variety R20D2043 is a novel hybrid produced from inbred varieties. It includes methods for producing plants with specific genetic traits through crossing and transformation. The variety encompasses seeds, plants, and their derivatives.
Sorghum, hybrid variety, genetic traits, backcross conversion
Patent
Resistive random-access memory structure and method
Patent published on the 2026-05-21 in US under Ref US20260141950 by GLOBALFOUNDRIES US INC [US] (Gopinath Venkatesh Periyapatna [us], Chinthu Siva Kumar [in], Jain Navneet K [us], Pasupula Suresh [in])
Abstract: Disclosed are a memory structure and an operating method. The structure includes: bit cells in columns and rows with all bit cells; source lines (SLs) and bit lines (BLs) for the columns; word lines (WL) for the rows; and peripheral circuitry to facilitate memory operations in a bit cell located in a selected column and a selected row. The peripheral circuitry includes a BL biasing circuit that applies an appropriate BL voltage to the BL for a selected column to achieve a desired memory operatio[...]
Our summary: The disclosed memory structure consists of bit cells organized in rows and columns, with associated source lines and bit lines. Peripheral circuitry is included to manage voltage applications for selected and unselected bit lines and source lines during memory operations. The biasing circuits ensure appropriate voltage levels are applied for effective write operations.
Resistive RAM, memory structure, biasing circuit, peripheral circuitry
Patent
A cd19/cd20 bispecific antibody with dual fc domains
Patent published on the 2026-05-21 in WO under Ref WO2026107318 by HINGE BIO INC [US] (Punnonen Juha [us], Chapin Steven [us], Lewis Gavin [us])
Abstract: Provided herein are methods for: rapidly depleting circulating B cells and remodeling one or more B cell compartments, treating B cell-related autoimmune diseases, and B cell malignancies, using B cell depleting antibodies that are directed to CD19 or CD20 and one or more target antigens. Further provided herein is a CD19/CD20 bispecific antibody with dual Fc domains that mediate enhanced effector functions and B cell depletion. HB2198 demonstrated enhanced binding to Fcγ receptors, potent effe[...]
Our summary: The content discusses a CD19/CD20 bispecific antibody designed for enhanced B cell depletion. It highlights methods for treating B cell-related autoimmune diseases and malignancies. The antibody exhibits improved binding to Fcγ receptors and potent effector functions.
bispecific antibody, CD19, CD20, Fc domains
Patent
Detection of antigen-specific t cell response in whole blood and pbmc samples
Patent published on the 2026-05-21 in WO under Ref WO2026106555 by AGENCY SCIENCE TECH & RES [SG] (Chang Zi Wei [sg], RÉnia Laurent Claude Stephane [sg], Chong Sher Ney [sg], Rouers Angeline Marie [sg], Tan Yong Jie [sg])
Abstract: This application relates to a method for detecting an antigen-specific T cell response in a whole blood or PBMC sample comprising collecting a sample, incubating the sample simultaneously with an antigen and a reporter cell line expressing at least one reporter gene that detects the presence of an antigen-specific T cell response product. It also relates to a vector for detecting an antigen-specific T cell response comprising a transcriptional response element and at least one reporter gene and [...]
Our summary: This method detects antigen-specific T cell responses in whole blood and PBMC samples. It involves incubating the sample with an antigen and a reporter cell line. A vector with a transcriptional response element and reporter gene is also included.
T cell response, antigen detection, PBMC samples, reporter gene
Patent
Reducing interleukin and chemokine using low anticoagulant heparin
Patent published on the 2026-05-21 in WO under Ref WO2026104634 by MATISSE PHARMACEUTICALS B V [NL] (Ekhart Peter Frank [nl], Jacobs Marcel Floris [nl], Groen Cornelis [nl])
Abstract: This invention is in the field of medicine. More particularly the invention is in the field of treating sepsis and related disorders, and disorder wherein certain cytokines are elevated. The invention further relates to treating diseases where cytokines need to be suppressed. Further described is a companion diagnostic test.[...]
Our summary: This invention focuses on using low anticoagulant heparin to reduce interleukin and chemokine levels. It targets the treatment of sepsis and related disorders characterized by elevated cytokines. Additionally, a companion diagnostic test is included to aid in treatment.
heparin, interleukin, chemokine, sepsis
Patent
Integrated circuit devices including stacked transistors with extended cell heights
Patent published on the 2026-05-21 in US under Ref US20260143794 by SAMSUNG ELECTRONICS CO LTD [KR] (Park Young Gook [us], Shin Hyo Jong [us], Lim Jinyoung [us], Seo Kang-ill [us])
Abstract: [0000] An integrated circuit device may include a substrate and a cell structure on an upper surface of the substrate. The cell structure may comprise at least a portion of a first transistor that comprises a first sidewall and a second sidewall that is opposite to the first sidewall and at least a portion of a second transistor that comprises a third sidewall and a fourth sidewall that is opposite to the third sidewall between the upper surface of the substrate and the first transistor. One of [...]
Our summary: The content describes an integrated circuit device featuring a substrate and a cell structure with stacked transistors. It highlights the relationship between the first and second transistors and their respective sidewalls. Additionally, it notes that the cell widths of the transistors differ.
integrated circuits, stacked transistors, cell structure, substrate
Patent
Topological phase transition induced by modulating unit cells in photonic Lieb lattice
Published on 2026-05-12 by Zhi-Kang Xiong, Y Liu (???), Xiying Fan and Bin Zhou @IOP SCIENCE
Abstract: Topological photonics was embarked from realizing the first-order chiral state in gyromagnetic media, but its higher-order states were mostly studied in dielectric lattice instead. In this paper we theoretically unveil a hierarchy of topological phases under broken time-reversal symmetry, which include the first-order Chern, and the second-order dipole, quadrupole phases. Concretely, by relaxing a certain spatial symmetry of unit cell, versatile topological phases including both edge and corner [...]
Our summary: This study reveals a hierarchy of topological phases in a photonic Lieb lattice under broken time-reversal symmetry. It identifies first-order Chern and second-order dipole and quadrupole phases by modulating unit cell symmetry. The findings may enhance sublattice engineering for robust waveguides and integrated photonic circuits.
Topological phase transition, Photonic Lieb lattice, Time-reversal symmetry, Gyromagnetic photonic crystals
Publication
Glioblastoma-Derived Extracellular Vesicles Modulate γδ T Lymphocytes Through a MIC-Dependent Mechanism
Published on 2026-02-03 by Micaela Rosato, Paula Saibene Vlez, Alejandra Infante Cruz, Matas A. Pibuel, Federico Fuentes, Mnica Vermeulen, Juan Iturrizaga, Pablo E. Espil, Silvia Berner, Gabriela V. Salamone, Carolina C. Jancic @MDPI
Abstract: Glioblastoma (GBM) is the most aggressive and common primary brain tumor, with a median survival of less than a year after diagnosis. γδ T lymphocytes are immune cells that can migrate to tumors and induce malignant cells’ apoptosis. Our previous in silico studies showed that higher γδ T-cell infiltration in GBM correlates with better patient survival, and in vitro experiments showed that GMB supernatants promote an antitumora[...]
Our summary: Glioblastoma-derived extracellular vesicles (EVs) modulate gamma delta T lymphocytes through a MIC-dependent mechanism. Increased CD69 expression, cytotoxicity, and cytokine production in T cells were observed following EV interaction. These findings offer insights for targeted immunotherapy development in glioblastoma patients.
Extracellular vesicles, Glioblastoma, Gamma delta T lymphocytes, Immunotherapy
Publication
