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皮肤维生素D合成

1930
  • Adolf Windaus
  • Kurt Huldschinsky
Laboratory scene depicting cutaneous vitamin D synthesis research in biochemistry.

(图片仅供参考)

Sunlight, specifically 紫外线 B (UVB) radiation with wavelengths between 290-315 nm, triggers the synthesis of vitamin D in the skin. When UVB photons strike the skin, they cause the photochemical conversion of 7-dehydrocholesterol into previtamin D3, which is then isomerized into vitamin D3 (cholecalciferol). This process is the primary natural source of vitamin D for humans.

The synthesis of vitamin D is a multi-step process essential for human health. It begins in the epidermis when UVB radiation breaks a 化学键 in 7-dehydrocholesterol, a derivative of cholesterol. The resulting compound, previtamin D3, is thermally unstable and rapidly rearranges itself into vitamin D3 (cholecalciferol). This vitamin D3 is then transported via the bloodstream to the liver, where it undergoes hydroxylation to become calcifediol (25-hydroxyvitamin D). Calcifediol is the main circulating form of vitamin D and is what is typically measured in blood tests. For its final activation, calcifediol travels to the kidneys (and other tissues), where it is converted into calcitriol (1,25-dihydroxyvitamin D), the biologically active form of the vitamin. Calcitriol functions as a hormone, primarily regulating calcium and phosphate levels in the blood, which is critical for bone mineralization. Several factors influence the efficiency of this process, including latitude, season, time of day, skin pigmentation (melanin acts as a natural sunblock), and the use of sunscreen, all of which can modulate the amount of UVB radiation reaching the skin’s precursor molecules.

UNESCO Nomenclature: 2401
– Biochemistry

类型

Biochemical Process

中断

重大的

用法

广泛使用

前体

  • 佝偻病的发现
  • identification of ‘fat-soluble factor a’ (later split into vitamins a and d) by elmer mccollum
  • theodor scherfig’s observation of sunlight’s benefits for children’s health
  • 有机化学的进步使得甾醇的分离和结构分析成为可能

应用程序

  • 佝偻病和骨软化症的治疗
  • 关于日晒的公共卫生建议
  • 强化牛奶和谷物等食物中的维生素 D
  • 维生素D补充剂的开发
  • 针对牛皮癣等皮肤病的 UVB 光疗法
  • 了解钙代谢和骨骼健康

专利:

NA

潜在创新理念

  • 智能窗户可传输有益的 UVB,同时阻挡有害的 UVA/UVC
  • wearable sensors that measure personal vitamin d production from sun exposure
  • 调节 UVB 穿透力的化妆品,可优化维生素 D 合成,且不会造成阳光损伤
  • 室内环境 LED 照明系统可发射精确的 UVB 波长,促进维生素 D 的生成
  • 基因工程益生菌,可在肠道中产生维生素 D 前体
  • 人工智能应用程序根据位置、皮肤类型和时间提供个性化的日晒建议
  • 缓慢释放 7-脱氢胆固醇的透皮贴剂,可在阳光不足的环境中增强维生素 D 的合成
  • 强化鱼饲料可提高养殖鱼体内的维生素 D 水平
  • hydroponic systems using tailored uvb light to boost vitamin d content in vegetables
  • 增强维生素 D 合成途径效率的药物
Related to: vitamin D, UVb radiation, sunlight, skin, 7-dehydrocholesterol, cholecalciferol, rickets, bone health, calcium metabolism, photochemistry.

历史背景

皮肤维生素D合成

1900
1910
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1930
1930
1940
1950
1880
1902
1920
1928
1930
1940
1950
1950

(如果日期未知或不相关,例如“流体力学”,则提供其显著出现的近似估计)

第十年 周年纪念日

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