
Bioinformatics integrates computational methods and statistical techniques to analyze and interpret biological data, particularly large-scale genomic, transcriptomic, proteomic, and metabolomic datasets. This domain addresses sequence alignment, genome assembly, gene expression profiling, protein structure prediction, and molecular interaction networks, facilitating insights into molecular function, evolutionary relationships, and disease mechanisms. Advances in algorithm development, machine learning applications, and high-throughput data processing enable comprehensive annotation, variant interpretation, and systems-level modeling. The following collection compiles the latest scientific publications and patented innovations focused on computational tools, database management, analytical pipelines, and integrative approaches essential for advancing biological research and precision medicine.
This is our latest selection of worldwide publications and patents in english on Bioinformatics, between many scientific online journals, classified and focused on genome sequenc, sequence alignment, protein structure prediction, phylogenetic, gene expression, next-generation sequencing, bioinformatic, computational genomic, transcriptomic, metagenomic, proteomics data analysis, molecular docking, biological database, structural bioinformatic, genome annotation, variant calling, epigenomic, systems biology, comparative genomic, functional genomic, RNA-Seq analysis, biostatistic, computational biology, biomarker discovery, pathway analysis and metabolomic.
A perspective on gene expression and regional brain sensitivity
Published on 2026-07-08 by @MIT
Abstract: AbstractNon-invasive transcranial ultrasound stimulation (TUS) enables deep brain therapeutic exploration at unprecedented scale. However, its optimal use is limited by the uncertainty surrounding ultrasound sensitivity across brain regions and cell types. This uncertainty often forces selection of sub-optimal parameter–target treatment paradigms guided solely by precedent, rather than an unbiased search of the larger combinatorial space. In principle, human brain-wide gene expression data cou[...]
Our summary: This perspective discusses the use of gene expression data to enhance transcranial ultrasound stimulation (TUS) parameter selection. It highlights the identification of regional gene expression clusters that may respond similarly to TUS. The findings emphasize the importance of optimizing stimulation parameters based on molecular profiles across different brain regions.
gene expression, transcranial ultrasound stimulation, brain regions, neuromodulation
Publication
Isosorbide for use in the treatment of oral inflammatory conditions
Patent published on the 2026-07-01 in EP under Ref EP4768025 by ROQUETTE FRERES [FR] (Mentink LÉon [fr], Wils Daniel [fr])
Abstract: The present disclosure relates to 1,4:3,6-dianhydrohexitol, specifically isosorbide, and compositions comprising 1,4:3,6-dianhydrohexitol for treating oral inflammatory conditions. These conditions, which include both oral mucosal inflammation and periodontal diseases, are characterized by elevated levels of pro-inflammatory mediators, particularly IL-1 alpha and IL-8. Using the EpiOral™ model, isosorbide has demonstrated significant ability to reduce IL-1 alpha secretion and IL-8 gene express[...]
Our summary: Isosorbide is effective in treating oral inflammatory conditions. It reduces IL-1 alpha secretion and IL-8 gene expression in inflamed oral epithelial cells. The findings support its therapeutic potential in modulating inflammation.
Isosorbide, oral inflammation, pro-inflammatory mediators, EpiOral™
Patent
Regulatory nucleic acid molecules for enhancing gene expression in plants
Patent published on the 2026-06-04 in WO under Ref WO2026114881 by BASF SE [DE] (Meulewaeter Frank [be], Davis Erin [be])
Abstract: The current disclosure generally relates to the technical field of plant molecular biology and provides methods for the production of high expressing promoters and the production of plants with enhanced expression of nucleic acids wherein one or more nucleic acid expression enhancing nucleic acid (NEENA) is functionally linked to said promoters and/or introduced into plants.[...]
Our summary: This disclosure focuses on enhancing gene expression in plants using regulatory nucleic acid molecules. It details methods for producing high-expressing promoters. The approach involves linking nucleic acid expression enhancing nucleic acids to these promoters in plants.
nucleic acid, gene expression, plant molecular biology, promoters
Patent
Aptamer specifically binding to cell-derived extracellular vesicles and method for discovering extracellular vesicle-specific biomarker using same
Patent published on the 2026-06-04 in WO under Ref WO2026117034 by KONKUK UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION [KR] (Park Ki Soo [kr], Lee Eun Sung [kr], Jun Jimin [kr], Cha Byung Seok [kr], Kim Junhyeong [kr])
Abstract: The present invention relates to an aptamer specifically binding to cell-derived extracellular vesicles and a method for discovering an extracellular vesicle-specific biomarker using same. Specifically, the present invention relates to an aptamer specifically binding to cancer cell-derived extracellular vesicles, and a method for discovering an extracellular vesicle-specific biomarker using same. Unlike prior art requiring immobilization, a method for selecting an aptamer specifically binding to[...]
Our summary: The invention presents an aptamer that binds specifically to cancer cell-derived extracellular vesicles. It includes a method for discovering extracellular vesicle-specific biomarkers without immobilization, maintaining the three-dimensional structure. This approach facilitates novel biomarker discovery and target protein verification for diagnosis and drug development.
Aptamer, extracellular vesicles, biomarker discovery, cancer
Patent
Rhamnolipids for modified gene expression during wound healing
Patent published on the 2026-06-04 in WO under Ref WO2026117688 by STEPAN CO [US] (Strout Kelly [us], Savanhu Faith [us], Sanders Mitch [us])
Abstract: The technology presented herein, in general, relates to the use of biosurfactants, such as rhamnolipids, for treating and/or accelerating the healing of wounds. More particularly, the present technology relates to a method for treating chronic and acute wounds, by applying a composition comprising a mixture of rhamnolipids to the wound, wherein application of the composition facilitates coordinated gene expression associated with wound healing.[...]
Our summary: Rhamnolipids are used to enhance gene expression during wound healing. The method involves applying a rhamnolipid composition to wounds. This approach aims to treat both chronic and acute wounds effectively.
Rhamnolipids, biosurfactants, gene expression, wound healing
Patent
Prediction of stage and survival using isoform expression in gastric adenocarcinoma
Patent published on the 2026-06-04 in US under Ref US20260155253 by UNIV OF SOUTH FLORIDA [US] (Kuo Paul [us], Liang Yifan [us], Lien Kyle [us])
Abstract: Various processes, methods and systems are provided herein for assisting patients, medical providers and other personnel in predicting cancer stage and cancer survival. The systems and methods include determining an indication of a preliminary cancer diagnosis of a given type of cancer for a patient, receiving results of transcriptional sequencing analysis, extracting a set of isoform expression information from transcriptomic data, processing a cancer stemness isoform dataset for a patient, and[...]
Our summary: The content discusses methods for predicting cancer stage and survival in gastric adenocarcinoma using isoform expression. It involves analyzing transcriptional sequencing data and extracting relevant isoform information. The goal is to assist patients and medical providers in making informed decisions based on cancer diagnosis.
isoform expression, gastric adenocarcinoma, cancer prediction, transcriptomic data
Patent
Galnac oligonucleotide conjugate for inhibiting c5 gene expression
Patent published on the 2026-05-28 in WO under Ref WO2026108942 by CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD [CN] (Zhang Xueyan [cn], Wang Lingyu [cn], Su Xiaoye [cn], Zhao Chenglong [cn])
Abstract: Provided are an oligonucleotide conjugate comprising a GalNAc derivative, a pharmaceutical composition comprising the oligonucleotide conjugate, and use of the oligonucleotide conjugate or the pharmaceutical composition.[...]
Our summary: The content discusses a GalNAc oligonucleotide conjugate designed to inhibit C5 gene expression. It includes details about the conjugate, its pharmaceutical composition, and its applications. The focus is on the development and use of this therapeutic approach.
GalNAc, oligonucleotide, gene expression, pharmaceutical composition
Patent
ReaxFF molecular dynamics investigation of co-combustion between Zhundong coal and lignin
Published on 2026-02-25 by @OXFORD
Abstract: AbstractCo-combustion of coal and biomass offers a promising solution to reduce fossil fuel dependency. This study employs reactive force-field molecular dynamics (ReaxFF MD) to investigate the microscopic effects of temperature and mixing ratio on Zhundong coal–lignin co-combustion. Elevated temperatures significantly enhance the conversion from large molecules to smaller gaseous products (CO2, H2O), suppressing tar formation. Higher coal ratios (3:1, 2:1) favor reduced tar yield and increase[...]
Our summary: This study uses ReaxFF molecular dynamics to analyze the co-combustion of Zhundong coal and lignin. Elevated temperatures and higher coal ratios improve gaseous product yields while reducing tar formation. Reaction pathways indicate distinct contributions from coal oxidation, lignin pyrolysis, and the behavior of nitrogen and sulfur during combustion.
ReaxFF, molecular dynamics, co-combustion, Zhundong coal
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