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Dernières publications et brevets en bioinformatique

Publications en bioinformatique, brevets

Astuce : suite à la sélection ci-dessous, vous pouvez rechercher et filtrer nos 2 bases de données complètes :

> outil de recherche de publications gratuit < par auteur, sujet, mots-clés, date ou revue.

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Bioinformatique
La bioinformatique combine des techniques informatiques et statistiques pour analyser des données biologiques complexes afin de mieux comprendre les fonctions moléculaires et les mécanismes des maladies.

La bioinformatique intègre des méthodes de calcul et des techniques statistiques pour analyser et interpréter les données biologiques, notamment les vastes ensembles de données génomiques, transcriptomiques, protéomiques et métabolomiques. Ce domaine couvre l'alignement de séquences, l'assemblage de génomes, le profilage de l'expression génique, la prédiction de la structure des protéines et les réseaux d'interactions moléculaires, permettant ainsi de mieux comprendre les fonctions moléculaires, les relations évolutives et les mécanismes pathologiques. Les progrès réalisés dans le développement d'algorithmes, les applications d'apprentissage automatique et le traitement de données à haut débit permettent une annotation exhaustive, l'interprétation des variants et la modélisation systémique. Le recueil suivant rassemble les publications scientifiques les plus récentes et les innovations brevetées axées sur les outils de calcul, la gestion de bases de données, les chaînes de traitement analytiques et les approches intégratives, essentiels pour faire progresser la recherche biologique et la médecine de précision.

Il s'agit de notre dernière sélection de publications et de brevets mondiaux en anglais sur la bioinformatique, parmi de nombreuses revues scientifiques en ligne, classées et axées sur le séquençage du génome, l'alignement des séquences, la prédiction de la structure des protéines, la phylogénétique, l'expression des gènes, le séquençage de la prochaine génération, la bioinformatique, la génomique computationnelle, transcriptomique, métagénomique, analyse de données protéomiques, docking moléculaire, base de données biologiques, bioinformatique structurelle, annotation du génome, appel de variants, épigénomique, biologie des systèmes, génomique comparative, génomique fonctionnelle, analyse RNA-Seq, biostatistique, biologie computationnelle, découverte de biomarqueurs, analyse des voies et métabolomique.

Regulatory nucleic acid molecules for enhancing gene expression in plants

Patent published on the 2026-06-04 in WO under Ref WO2026114881 by BASF SE [DE] (Meulewaeter Frank [be], Davis Erin [be])

Abstract: The current disclosure generally relates to the technical field of plant molecular biology and provides methods for the production of high expressing promoters and the production of plants with enhanced expression of nucleic acids wherein one or more nucleic acid expression enhancing nucleic acid (NEENA) is functionally linked to said promoters and/or introduced into plants.[...]


Our summary: This disclosure focuses on enhancing gene expression in plants using regulatory nucleic acid molecules. It details methods for producing high-expressing promoters. The approach involves linking nucleic acid expression enhancing nucleic acids to these promoters in plants.

nucleic acid, gene expression, plant molecular biology, promoters

Patent

Aptamer specifically binding to cell-derived extracellular vesicles and method for discovering extracellular vesicle-specific biomarker using same

Patent published on the 2026-06-04 in WO under Ref WO2026117034 by KONKUK UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION [KR] (Park Ki Soo [kr], Lee Eun Sung [kr], Jun Jimin [kr], Cha Byung Seok [kr], Kim Junhyeong [kr])

Abstract: The present invention relates to an aptamer specifically binding to cell-derived extracellular vesicles and a method for discovering an extracellular vesicle-specific biomarker using same. Specifically, the present invention relates to an aptamer specifically binding to cancer cell-derived extracellular vesicles, and a method for discovering an extracellular vesicle-specific biomarker using same. Unlike prior art requiring immobilization, a method for selecting an aptamer specifically binding to[...]


Our summary: The invention presents an aptamer that binds specifically to cancer cell-derived extracellular vesicles. It includes a method for discovering extracellular vesicle-specific biomarkers without immobilization, maintaining the three-dimensional structure. This approach facilitates novel biomarker discovery and target protein verification for diagnosis and drug development.

Aptamer, extracellular vesicles, biomarker discovery, cancer

Patent

Rhamnolipids for modified gene expression during wound healing

Patent published on the 2026-06-04 in WO under Ref WO2026117688 by STEPAN CO [US] (Strout Kelly [us], Savanhu Faith [us], Sanders Mitch [us])

Abstract: The technology presented herein, in general, relates to the use of biosurfactants, such as rhamnolipids, for treating and/or accelerating the healing of wounds. More particularly, the present technology relates to a method for treating chronic and acute wounds, by applying a composition comprising a mixture of rhamnolipids to the wound, wherein application of the composition facilitates coordinated gene expression associated with wound healing.[...]


Our summary: Rhamnolipids are used to enhance gene expression during wound healing. The method involves applying a rhamnolipid composition to wounds. This approach aims to treat both chronic and acute wounds effectively.

Rhamnolipids, biosurfactants, gene expression, wound healing

Patent

Prediction of stage and survival using isoform expression in gastric adenocarcinoma

Patent published on the 2026-06-04 in US under Ref US20260155253 by UNIV OF SOUTH FLORIDA [US] (Kuo Paul [us], Liang Yifan [us], Lien Kyle [us])

Abstract: Various processes, methods and systems are provided herein for assisting patients, medical providers and other personnel in predicting cancer stage and cancer survival. The systems and methods include determining an indication of a preliminary cancer diagnosis of a given type of cancer for a patient, receiving results of transcriptional sequencing analysis, extracting a set of isoform expression information from transcriptomic data, processing a cancer stemness isoform dataset for a patient, and[...]


Our summary: The content discusses methods for predicting cancer stage and survival in gastric adenocarcinoma using isoform expression. It involves analyzing transcriptional sequencing data and extracting relevant isoform information. The goal is to assist patients and medical providers in making informed decisions based on cancer diagnosis.

isoform expression, gastric adenocarcinoma, cancer prediction, transcriptomic data

Patent

Galnac oligonucleotide conjugate for inhibiting c5 gene expression

Patent published on the 2026-05-28 in WO under Ref WO2026108942 by CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD [CN] (Zhang Xueyan [cn], Wang Lingyu [cn], Su Xiaoye [cn], Zhao Chenglong [cn])

Abstract: Provided are an oligonucleotide conjugate comprising a GalNAc derivative, a pharmaceutical composition comprising the oligonucleotide conjugate, and use of the oligonucleotide conjugate or the pharmaceutical composition.[...]


Our summary: The content discusses a GalNAc oligonucleotide conjugate designed to inhibit C5 gene expression. It includes details about the conjugate, its pharmaceutical composition, and its applications. The focus is on the development and use of this therapeutic approach.

GalNAc, oligonucleotide, gene expression, pharmaceutical composition

Patent

Products and methods for full-length smchd1 expression using split inteins

Patent published on the 2026-05-21 in WO under Ref WO2026107323 by RESEARCH INST AT NATIONWIDE CHILDRENS HOSPITAL [US] (Harper Scott Q [us], Thangaraj Merlin Premalatha [us])

Abstract: Nucleic acids, vectors, compositions, systems, and methods for expressing a structural maintenance of chromosomes hinge domain containing 1 (SMCHD1) polypeptide to epigenetically silence double homeobox 4 (DUX4) for the treatment of a disease or disorder associated with DUX4 are provided. DUX4 regulates gene expression and plays a role in development, muscular dystrophy (including, but not limited to, facioscapulohumeral dystrophy (FSHD)), a cancer, or Bosma arhinia microphthalmia syndrome (BAMS[...]


Our summary: This content discusses products and methods for expressing the SMCHD1 polypeptide using split inteins. It highlights the role of DUX4 in diseases like muscular dystrophy and cancer. The approach aims to downregulate DUX4 expression for therapeutic purposes.

SMCHD1, split inteins, gene expression, DUX4

Patent

ReaxFF molecular dynamics investigation of co-combustion between Zhundong coal and lignin

Published on 2026-02-25 by @OXFORD

Abstract: AbstractCo-combustion of coal and biomass offers a promising solution to reduce fossil fuel dependency. This study employs reactive force-field molecular dynamics (ReaxFF MD) to investigate the microscopic effects of temperature and mixing ratio on Zhundong coal–lignin co-combustion. Elevated temperatures significantly enhance the conversion from large molecules to smaller gaseous products (CO2, H2O), suppressing tar formation. Higher coal ratios (3:1, 2:1) favor reduced tar yield and increase[...]


Our summary: This study uses ReaxFF molecular dynamics to analyze the co-combustion of Zhundong coal and lignin. Elevated temperatures and higher coal ratios improve gaseous product yields while reducing tar formation. Reaction pathways indicate distinct contributions from coal oxidation, lignin pyrolysis, and the behavior of nitrogen and sulfur during combustion.

ReaxFF, molecular dynamics, co-combustion, Zhundong coal

Publication

A Comparative Study of CNN, BiLSTM, and GRU Architectures

Published on 2026-02-03 by Elias Tabane, Ernest Mnkandla, Zenghui Wang @MDPI

Abstract: DNA sequence classification is a fundamental problem in bioinformatics, playing an indispensable role in gene annotation and disease prediction. Whereas most deep learning models, such as CNNs, BiLSTM networks, and GRUs, have been found individually optimal, each of these methods excels in modeling a specific aspect of sequence data: local motifs, long-range dependencies, and efficient temporal modeling of the sequences. Here, we present and evaluate an ensemble model that integrates CNN, BiLSTM[...]


Our summary: This study evaluates CNN, BiLSTM, and GRU architectures for DNA sequence classification. An ensemble model combining these methods achieved a classification accuracy of 90.6%, outperforming individual models. The research highlights the effectiveness of hybrid deep learning in genomic data analysis.

CNN, BiLSTM, GRU, ensemble

Publication

Sujets abordés : Bioinformatique, techniques informatiques, techniques statistiques, données biologiques, ensembles de données génomiques, ensembles de données transcriptomiques, ensembles de données protéomiques, ensembles de données métabolomiques, alignement de séquences, assemblage de génomes, profilage de l'expression des gènes, prédiction de la structure des protéines, réseaux d'interactions moléculaires, apprentissage automatique, traitement de données à haut débit, interprétation des variantes, modélisation au niveau des systèmes, médecine de précision, ISO/IEC 27001, ISO 9001, ISO/IEC 25010, ISO 31000 et ISO 13485.

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