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| Date* | Country ** | Status | Ref | id | Title | abstract | Applicant | Origin *** | Inventors | Details | Full |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2024-09-18 | MX | A | MX2024011126 | 10.000 | Compressor device, and method for operating a compressor device. | The invention relates to a compressor device with a screw-type compressor, by way of which a compressed air/oil mixture can be produced; a compressor outlet; an oil separator, to which the compressed air/oil mixture can be transferred and by way of which compressed air and oil from the compressed air/oil mixture can be separated from one another, and the compressed air can be output to the compressor outlet; an oil return which connects the oil separator to the screw-type compressor, wherein the oil return comprises a fan device at an oil cooler; and a control device, by means of which a rotational speed (n) of the fan device and therefore also the cooling of the oil at the oil cooler are adjustable. | KAESER KOMPRESSOREN SE [DE] | DE | Gutsche Michael [de], Marx Annika | ||
| 2024-09-18 | MX | A | MX2024011181 | 10.001 | Hydroxypropyl methyl cellulose derivatives to stabilize polypeptides. | The present invention provides formulations comprising polypeptides and hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives. The formulations are stable; for example, during high temperature processing and in possible low pH environments. In addition, the HPMCAS derivatives provide protection to a pH sensitive protein against acidic degradation products from aqueous hydrolysis of poly(lactic-co- glycolic acid) (PLGA) in PLGA-based delivery systems. | GENENTECH INC [US] | US | Nayak Purnendu Kumar [us], Chang Debby Pei- Shan, Rajagopal Karthikan, Zarzar Jonathan | ||
| 2024-09-18 | MX | A | MX2024011200 | 10.002 | Cancer diagnostics and treatment by means of prmt5 inhibitor. | The present invention relates to patient selection methods and methods of treating cancers with a protein arginine methyltransferase 5 (PRMT5) inhibitor. The expression level of the retinoblastoma tumour suppressor protein (pRb) and/or total E2F1 protein in a cancer cell containing biological sample from the patient is used to determine whether a patient should be treated with a PRMT5 inhibitor. | ARGONAUT THERAPEUTICS LTD [GB] | GB | La Thangue Nicholas [gb], Munro Shonagh | ||
| 2024-09-18 | MX | A | MX2024011102 | 10.003 | Method, device, and program for predicting delayed fracture in press-formed article, and method for manufacturing press-formed article. | The method for predicting delayed fracture in a press-formed article pertaining to the present invention includes: a step (S1) for calculating a stress distribution and a strain distribution of a press-formed article; a step (S5) for setting a hydrogen concentration distribution corresponding to the strain distribution calculated for the press-formed article on the basis of an expression relating strain and hydrogen concentration that is acquired in advance for a high-tensile steel plate; a step (S7) for performing a hydrogen diffusion analysis for the press-formed article on the basis of the stress distribution and the hydrogen concentration distribution and calculating a hydrogen concentration distribution after hydrogen diffusion; and a step (S9) for predicting a site of occurrence of delayed fracture in the press-formed article on the basis of a delayed fracture determination condition based on the stress, strain, and hydrogen concentration acquired in advance, and the stress distribution, the strain distribution, and the hydrogen concentration distribution after hydrogen diffusion. | JFE STEEL CORP [JP] | JP | Minote Toru [jp], Ishiwatari Akinobu, Tatsukawa Koji | ||
| 2024-09-18 | MX | A | MX2024011114 | 10.004 | New forms of n-(5-((6,7-dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)- 1-propyl-4-(2,2,2-trifluoroethoxy)-1h-pyrazole-3-carboxamide hydrochloride. | The present invention relates to new forms of inhibitors of Axl/Mer receptor tyrosine kinase and CSF1R (colony stimulating factor 1 receptor), and in particular to new forms of N-(5-((6,7-dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-1-propyl-4- (2,2,2-trifluoro- ethoxy)-1H-pyrazole-3-carboxamide hydrochloride. | QURIENT CO LTD [KR] | KR | Nam Kiyean [kr], Kim Jaeseung, Jeon Borami | ||
| 2024-09-18 | MX | A | MX2024010960 | 10.005 | Modular vector (modvec) system: a platform for construction of next generation expression vectors. | The present invention is directed to a method for optimizing the expression levels of a multi- chain protein wherein the protein comprises at least two different polypeptide chains. The generation of multi-chain proteins presents great challenges due to the pairing/folding of new quaternary structures composed of multiple polypeptide chains, particularly when pairing antibody heavy and light chains in a multispecific format. Of critical import to efficient and proper assembly of multiple polypeptide chain molecules is expression of the different chains at the proper ratio within the cell The present invention addresses these issues. | AMGEN INC [US] | US | Belouski Edward J [us], Mock Marissa, Chen Fuyi | ||
| 2024-09-18 | MY | A | MY204832 | 10.006 | One way torque planetary gear system (owtpgs) | The present invention generally relates to improvements in one way rotation system. This one way rotation system particularly use planetary gear system with internal latch teeth (10a) as unique way to perform one way rotation mechanism. There are known one way rotation mechanism systems such sprag clutch, one war bearing and freewheel. However because of conventional system such as sprag clutch and one way bearing uses friction to perform one way rotation mechanism, the mechanism will induce grinding between ball bearing/sprag and bearing's wall and eventually reduce lifespan of bearing/sprag clutch. Meanwhile freewheel uses locking mechanism to operate one way rotation system, the mechanism will generate noise due to hammering between locking levers and freewheel gear's teeth. The present invention discloses a one way rotation system (Fig 3) comprising of planetary gear latches and an internal gear as main components of the system to lock input of shaft rotation (3-I) with output shaft rotation (3-0) in one direction of rotation only. The locking mechanism happen when input shaft rotate clockwise direction and the rotation caused latching leg (Sa) to lock itself to internal latch teeth (10a) and cause planetary gear latch to stop rotating and lock itself to internal gear and eventually lock rotation of input shaft with output shaft as shown in Fig 3a. | MOHAMAD NAZMEE BIN MAKHTAR [MY] | MY | Mohamad Nazmee Bin Makhtar [my] | ||
| 2024-09-18 | MX | A | MX2024008148 | 10.007 | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases. | The present invention relates to dihydronaphthyridines and related compounds, and methods for treating or preventing proliferative diseases comprising the administration of an effective amount thereof. Also, it discloses the unexpected utility of compounds that inhibit cKIT kinase over a wide range of c-KIT mutations, including complex occurrences of primary mutations (KIT exon 9 or 11) and secondary mutations of KIT (exons 13, 14, 17, and 18) that can arise in individual patients with refractory GIST. | DECIPHERA PHARMACEUTICALS LLC [US] | US | Flynn Daniel L [us], Kaufman Michael D, Petillo Peter A | ||
| 2024-09-18 | MX | A | MX2024008149 | 10.008 | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases. | The present invention relates to dihydronaphthyridines and related compounds, and methods for treating or preventing proliferative diseases comprising the administration of an effective amount thereof. Also, it discloses the unexpected utility of compounds that inhibit cKIT kinase over a wide range of c-KIT mutations, including complex occurrences of primary mutations (KIT exon 9 or 11) and secondary mutations of KIT (exons 13, 14, 17, and 18) that can arise in individual patients with refractory GIST. | DECIPHERA PHARMACEUTICALS LLC [US] | US | Flynn Daniel L [us], Kaufman Michael D, Petillo Peter A | ||
| 2024-09-18 | MX | A | MX2024008800 | 10.009 | Activin receptor type iib variants and uses thereof. | There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia). | 35PHARMA INC [CA] | CA | Tremblay Gilles [ca], O''connor-mccourt Maureen, Ganesh Vannakambadi K, Schang Gauthier | ||
| 2024-09-18 | MX | A | MX2024008407 | 10.010 | Crystalline forms of 3-(5-(2-hydroxy-2-methylpropoxy)-6-methylpyr azin-2-yl)-1h-indole-7-carbonitrile. | This disclosure provides crystalline forms of an androgen receptor modulator of formula and methods of making and using these forms. | NIDO BIOSCIENCES INC [US] | US | Toure Bakary-barry [us], Ronn Magnus | ||
| 2024-09-18 | MX | A | MX2024008220 | 10.011 | Global confidence classifier for information retrieval in contact centers. | A method of leveraging a global confidence classifier for information retrieval in contact centers according to an embodiment includes receiving, by a computing system, a user query from a contact center client communication with a knowledge-only bot of the computing system, performing, by the computing system, feature extraction on the user query by converting query words of the user query into a numerical vector representation of the user query, identifying, by the computing system, a subset of documents most likely to be responsive to the user query, and re-ranking, by the computing system, the subset of documents most likely to be responsive to the user query based on a global confidence classifier model. | GENESYS CLOUD SERVICES INC [US] | US | Elluru Veera Raghavendra [in], Sundaram Ramasubramanian, George Basil, Elluru Naresh Kumar, Buduguppa Pavan Kumar | ||
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