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Neueste Veröffentlichungen und Patente zur Synthetischen Biologie

Synthetische Biologie

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Synthetische Biologie
Synthetische Biologie nutzt die Technik und Molekularbiologie um biologische Systeme für verschiedene Anwendungen zu erneuern und zu verändern.

Die synthetische Biologie integriert Prinzipien der Ingenieurwissenschaften und der Molekularbiologie, um biologische Systeme mit neuartigen Funktionen zu entwerfen, zu konstruieren und zu modifizieren. Sie umfasst die Assemblierung standardisierter genetischer Bausteine, den Aufbau synthetischer Genkreisläufe und die Reprogrammierung des Zellstoffwechsels zur Erzeugung maßgeschneiderter Organismen oder biologischer Komponenten. Zu den Techniken gehören Genomeditierung, DNA-Synthese und Stoffwechselwegoptimierung zur Entwicklung von Anwendungen in den Bereichen Therapie, Biokraftstoffe, Biosensorik und Bioproduktion. Dieses Forschungsgebiet erweitert das Verständnis biologischer Komplexität durch die Schaffung orthogonaler Systeme, minimaler Zellen und synthetischer regulatorischer Netzwerke. Die folgende Zusammenstellung präsentiert aktuelle Publikationen und Patente, die Innovationen bei Werkzeugen, Methoden und Anwendungen innerhalb der synthetischen Biologie detailliert beschreiben:

Dies ist unsere neueste Auswahl an weltweiten Veröffentlichungen und Patenten in englischer Sprache zum Thema Synthetische Biologie, klassifiziert und fokussiert auf Genschaltkreise, Metabolic Engineering, DNA-Synthese, Genom-Editierung, Crispr Cas9, synthetisches Genom, Biobrick, genetische Teile, Protein-Engineering, Zellchassi, Biosensor, Pfadoptimierung, Genexpressionskontrolle, synthetischer Promotor, rna device, Minimalzelle, orthogonales System, genetischer Kippschalter, synthetisches Operon, Stoffwechselweg, gerichtete Evolution, synthetisches regulatorisches Netzwerk, dna assembl, zellfreies System, synthetische Transkription, Erweiterung des genetischen Codes, synthetisches Biolog, Analyse des Stoffwechselflusses, synthetisches Gen und biocontainment strateg.

Electrode, biosensor, and electrode manufacturing method

Patent published on the 2026-07-02 in WO under Ref WO2026140553 by NITTO DENKO CORP [JP] (Fukuda Keita [jp], Yamashita Takayuki [jp], Kamano Yusuke [jp])

Abstract: This electrode comprises a substrate film and a conductive carbon layer in this order toward one side in the thickness direction. The electrode satisfies expression. Expression: 0.30[...]


Our summary: This content discusses an electrode that consists of a substrate film and a conductive carbon layer. It highlights a specific manufacturing method for the electrode. The electrode meets a defined expression value of 0.30.

Electrode, biosensor, conductive carbon, substrate film

Patent

Systems and methods for estrogen biosensing

Patent published on the 2026-06-25 in US under Ref US20260176666 by BIOSENS8 INC [US] (Kuzmanovic Uros [us], Charles Jr Roger J [us], Davis Connor A [us])

Abstract: The present disclosure generally relates to enzyme-based biosensors and, in particular, to biosensors for determining estrogen and other biomolecules. In some cases, the enzymes may be based on dehydrogenases, such as 17-beta hydroxysteroid dehydrogenases. In certain embodiments, the enzyme may include an active site that is able to bind to and oxidize estrogen, or other biomolecules. In some cases, the active site may include certain residues positioned around the active site that are able to s[...]


Our summary: The disclosure describes enzyme-based biosensors for detecting estrogen and other biomolecules. It focuses on dehydrogenases that oxidize estrogen through specific active sites. Methods for creating and utilizing these biosensors and related kits are also discussed.

biosensors, estrogen, dehydrogenases, enzyme-based

Patent

Expanded metabolic pathway for androgen production by commensal bacteria

Patent published on the 2026-06-25 in US under Ref US20260177553 by THE BRD OF TRUSTEES OF THE UNIV OF ILLINOIS [US] (Ridlon Jason M [us])

Abstract: [0000] Provided herein is the first commensal microbial gene encoding an enzyme that catalyzes the conversion of androstenedione to epitestosterone in the gut bacterium Clostridium scindens (desF). Also provided is an important and unrecognized capability for epitestosterone in androgen receptor-dependent prostate cancer cell proliferation and the potential clinical relevance of this bacterial enzymatic pathway (desF) in prostate cancer. Additionally, it was discovered that bacterial isolates fr[...]


Our summary: A novel microbial gene (desF) in Clostridium scindens converts androstenedione to epitestosterone. This pathway is linked to prostate cancer cell proliferation. Additionally, urinary isolates demonstrate the ability to produce androgens through the enzyme 17β-hydroxysteroid dehydrogenase (desG).

androgen production, commensal bacteria, Clostridium scindens, prostate cancer

Patent

Biosensor device

Patent published on the 2026-06-18 in WO under Ref WO2026127530 by WISOL CO LTD [KR] (Kim Jung Min [kr], Lee Ho Sub [kr])

Abstract: A biosensor device according to the present invention comprises: a printed circuit board in which at least one sample seating hole for seating a test sample is formed to have a hollow structure; a biosensor which is coupled to a position corresponding to the sample seating hole on the lower surface of the printed circuit board, and senses a sample reaction of the test sample; and a case having an inner space for accommodating the printed circuit board.[...]


Our summary: The biosensor device features a printed circuit board with a hollow sample seating hole. It includes a biosensor positioned beneath the hole to detect sample reactions. The device is housed in a case that accommodates the printed circuit board.

biosensor, printed circuit board, sample seating hole, test sample

Patent

Human cell-free system for high-throughput screening for new compounds for targeted protein degradation

Patent published on the 2026-06-17 in EP under Ref EP4759936 by FRAUNHOFER GES FORSCHUNG [DE] (Hahnengress Nils [de], Buntru Matthias [de])

Abstract: The present invention relates to a cell lysate wherein the lysis buffer comprises at least one of magnesium acetate, phosphorylation inhibitor K3L, an agonist of dephosphorylation GADD34 and/or a caspase inhibitor for use in, or as, a cell-free system and a method for preparing a cell-free protein synthesis system. Further provided is a method for expressing a protein in the cell-free protein synthesis system, a method for screening for a candidate compound for an effect on a target molecule and[...]


Our summary: The invention describes a human cell-free system for high-throughput screening of compounds targeting protein degradation. It includes a cell lysate with specific components for enhanced protein synthesis. Additionally, methods for expressing proteins and screening candidate compounds are provided, along with a related kit.

cell-free system, high-throughput screening, targeted protein degradation, protein synthesis

Patent

Spot drops biosensor nutrient management

Patent published on the 2026-06-11 in WO under Ref WO2026122877 by SOUTH DAKOTA BOARD OF REGENTS [US] (Khalid Ahmed [us], Mirzaee Salman [us], Mirzakhani Nafchi Ali [us], Kumari Karishma [us])

Abstract: Disclosed herein are methods and systems of detecting nutrient deficiencies in an agricultural field and creating a variable rate fertilizer application map by analyzing a field for standard vegetation markers, creating a management zone map having management zones based on the standard vegetation markers, wherein the management zones are assigned based on commonality in the standard vegetation markers. Applying a standard nutrient fertilizer to the field, assigning a plurality of biosensor rich[...]


Our summary: The system detects nutrient deficiencies in agricultural fields using biosensors. It creates a variable rate fertilizer application map based on vegetation markers and management zones. Fertilizer is applied variably using controlled spray nozzles to optimize yield.

biosensor, nutrient management, variable rate application, agricultural technology

Patent

Ethical and Clinical Best Practices for Genome Editing Applications

Published on 2026-02-02 by Mara Ortiz-Bueno, Federica Zinghirino, Pilar Puig Serra, Kyriaki Paschoudi, Lluis Montoliu, Erden Atilla, Yonglun Luo, Alessia Cavazza, Carsten W. Lederer, Karim Benabdellah @MDPI

Abstract: Genome editing (GE) has transformed medicine by allowing precise changes to DNA, offering potential treatments for a range of inherited and acquired disorders. Several technologies support these advances, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-based systems, of which the latter has emerged as the most accessible, versatile, and popular. While GE holds great promise, i[...]


Our summary: Genome editing technologies enable precise DNA modifications for medical treatments. Ethical and regulatory considerations are crucial for safe clinical applications. Regulatory agencies provide guidance on safety, consent, and compliance in genome editing practices.

Genome Editing, Ethical Standards, Regulatory Compliance, Clinical Applications

Publication

Bacillus velezensis Enhances Rice Resistance to Brown Spot by Integrating Antifungal and Growth Promotion Functions

Published on 2026-02-01 by Elizabeth B. E. Pires, Maira S. Tique Obando, Luis Janssen, Bergmann M. Ribeiro, Odaiza F. Souza, Marcelo L. Dias, Lus O. Viteri Jumbo, Rodrigo R. Fidelis, Gil R. Santos, Raimundo N. C. Rocha, Guy Smagghe, Tito Bacca, Eugenio E. Oliveira, Rudolf Haumann, Raimundo W. S. Aguiar @MDPI

Abstract: Brown spot, caused by the seedborne fungus Bipolaris oryzae, remains a major constraint in rice production. Here, we used in vitro and in vivo assays to evaluate the biocontrol potential of three Bacillus strains (Ba. cereus OQ725688.1, Ba. velezensis OP938696.1, and Ba. subtilis OP937353.1) against Bi. oryzae in two rice cultivars (&amp;ldquo;Rubelita&amp;rdquo; and &amp;ldquo;Predileta&amp;rdquo;). Ba. cereus showed the highest in vitro mycelial inhibition (&amp;asymp;95%),[...]


Our summary: Bacillus velezensis enhances rice resistance to brown spot by integrating antifungal and growth promotion functions. It effectively reduces disease severity and increases seedling vigor compared to infected controls. The strain exhibits unique biochemical traits and potential for sustainable rice protection strategies.

Bacillus velezensis, biocontrol, rice resistance, antifungal

Publication

Behandelte Themen: Synthetische Biologie, Engineering, Molekularbiologie, genetische Teile, synthetische Genschaltkreise, zellulärer Stoffwechsel, Genom-Editierung, DNA-Synthese, Optimierung von Stoffwechselwegen, Therapeutika, Biokraftstoffe, Biosensorik, Bioproduktion, orthogonale Systeme, Minimalzellen, synthetische regulatorische Netzwerke, ISO 22174, ISO 16140, ISO 20391, ISO 13485 und ASTM E2875.

Glossar der verwendeten Begriffe

Deoxyribonucleic Acid (DNA): Ein Molekül, das aus zwei Strängen besteht, die eine Doppelhelix bilden. Es besteht aus Nukleotiden, die genetische Informationen durch Sequenzen von vier Basen kodieren: Adenin, Thymin, Cytosin und Guanin. Es dient als Erbmaterial in den meisten lebenden Organismen.

Historischer Kontext

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