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Publicações recentes e patentes em biologia sintética

Synthetic Biology

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Synthetic biology
Synthetic biology leverages engineering and molecular biology to innovate and modify biological systems for diverse applications.

Synthetic biology integrates principles of engineering and biologia molecular to design, construct, and modify biological systems with novel functions. It involves the assembly of standardized genetic parts, construction of synthetic gene circuits, and reprogramming of cellular metabolism to create tailored organisms or biological components. Techniques include genome editing, DNA synthesis, and pathway optimization to develop applications in therapeutics, biofuels, biosensing, and biomanufacturing. This domain advances understanding of biological complexity through the creation of orthogonal systems, minimal cells, and synthetic regulatory networks. Our following compilation presents recent publications and patents detailing innovations in tools, metodologias, and applications within synthetic biology:

Esta é a nossa mais recente seleção de publicações e patentes mundiais em inglês sobre Biologia Sintética, provenientes de diversos periódicos científicos online, classificadas e focadas em circuitos genéticos, engenharia metabólica, síntese de DNA, edição genômica, CRISPR Cas9, genoma sintético, biobrick, componentes genéticos, engenharia de proteínas, chassis celulares, biossensores, otimização de vias metabólicas, controle da expressão gênica, promotores sintéticos, dispositivos de RNA, células mínimas, sistemas ortogonais, interruptores genéticos, operons sintéticos, vias metabólicas, evolução dirigida, redes regulatórias sintéticas, montagem de DNA, sistemas acelulares, transcrição sintética, expansão do código genético, biologia sintética, análise de fluxo metabólico, genes sintéticos e estratégias de biocontenção.

Switch sensors and methods of use

Patent published on the 2026-10-15 in US under Ref US20260318905 by BOARD OF REGENTS THE UNIV OF TEXAS SYSTEM [US] (Ye Jing Yong [us], Trabucco Luis [us], Shaw Jonathan [us])

Abstract: Current fluorescent biosensors rely on fluorescent spectrum shifts, limiting the detection technique compatible with the technology. These limitations hinder the ability to utilize fluorescent biosensing technologies in vivo. Switch sensors are biosensors that allow for the sensitive detection of target analytes through a diverse set of detection techniques. Switch sensor monomers are comprised of a platform segment, a linker, and a fluorescent dye monomer. The aptamer or polypeptide-based platf[...]


Our summary: Switch sensors enhance biosensing by enabling diverse detection methods beyond fluorescence. They consist of a platform segment, linker, and fluorescent dye monomer. The binding of target analytes alters the absorption spectrum, expanding detection capabilities.

biosensors, switch sensors, detection techniques, fluorescent dyes

Patent

Biosensor and concentration measuring device

Patent published on the 2026-10-15 in WO under Ref WO2026216315 by KYOTO UNIV [JP] (Sowa Keisei [jp], Kitazumi Yuki [jp], Adachi Taiki [jp])

Abstract: The present invention realizes a biosensor that can measure the concentration of a measurement target component with high accuracy even in a flowing liquid, and can maintain measurement accuracy even when the concentration of the measurement target component changes rapidly. A measurement space is formed at the distal end of an insertion part, and an electrode is installed therein. When moving a measurement space forming unit, it is possible to switch between: a first state in which the measur[...]


Our summary: The invention describes a biosensor capable of accurately measuring the concentration of a target component in a flowing liquid. It features a measurement space that can switch between states to facilitate liquid flow and maintain measurement accuracy. This design allows for precise concentration monitoring even during rapid changes in the target component s concentration.

biosensor, concentration measurement, flowing liquid, measurement accuracy

Patent

Compositions and methods for increasing resistance to soybean cyst nematode

Patent published on the 2026-10-08 in WO under Ref WO2026213410 by PIONEER HI BRED INT INC [US] (Allen Jonathan B [us], Huitt Nichole [us], Kyle Donald [us], Lenis Julian Mario [us], Tabor Girma M [us], Thatcher Shawn [us], Woodward John Bryan [us], Yeckel Gregory [us], Zhang Wenjing [us])

Abstract: Provided are plants, cells, tissues, and germplasm thereof comprising gene and marker alleles associated with increased resistance to soybean cyst nematode (SCN). Also provided are breeding methods and methods of identifying and selecting plants having alleles associated with increased resistance to SCN. Transgenic and genome edited plants comprising the gene alleles associated with increased SCN resistance are provided.[...]


Our summary: This content discusses compositions and methods to enhance resistance to soybean cyst nematode in plants. It includes details on gene and marker alleles linked to increased resistance. Additionally, it covers breeding techniques and the development of transgenic and genome-edited plants for improved SCN resistance.

soybean cyst nematode, resistance genes, transgenic plants, breeding methods

Patent

Electrochemical biosensors, systems, and methods of use

Patent published on the 2026-10-08 in US under Ref US20260309671 by THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS [US] (Mathew Mathew Thoppil [us])

Abstract: Various examples are provided related to electrochemical biosensors, systems, and methods of use. A biomarker associated with a disease in a biological fluid sample can be detected by first contacting the biological fluid sample with a working electrode of an electrochemical biosensor. Next, one or more changes in an electronic property of the working electrode resulting from binding of the biomarker to the capture agent can be detected. Then, electrochemical data can be determined based at leas[...]


Our summary: Electrochemical biosensors detect disease biomarkers in biological fluids. Changes in electronic properties of working electrodes indicate biomarker binding. Machine learning models analyze electrochemical data to assess disease risk levels.

biosensors, electrochemistry, biomarkers, machine learning

Patent

Inhibitory compounds

Patent published on the 2026-10-01 in WO under Ref WO2026202506 by LOQUS23 THERAPEUTICS LTD [GB] (Hardick David [gb], Reynolds David [gb], Drouhin Pauline [gb])

Abstract: The present invention relates at least in part to certain compounds that function as inhibitors of MutSβ. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which MutSβ activity is implicated, such as, for example, repeat expansion diseases or disorders, as well as to increase the efficiency of genome editing.[...]


Our summary: The invention involves compounds that inhibit MutSβ. It includes methods for preparing these compounds and their pharmaceutical applications. These compounds are relevant for treating repeat expansion diseases and enhancing genome editing efficiency.

inhibitory compounds, MutSβ, pharmaceutical compositions, genome editing

Patent

Biosensor and system for measuring concentration of salivary glucose

Patent published on the 2026-10-01 in WO under Ref WO2026206003 by DONGWOON ANATECH CO LTD [KR] (Kwon Min Su [kr], Kim Mi Rim [kr], Im Eun Hye [kr], Jang In Su [kr])

Abstract: The present invention relates to a biosensor for detecting glucose in saliva, comprising: a lower plate including a working electrode for detecting glucose in saliva, the working electrode including at least one working electrode protrusion, and a reference electrode for detecting glucose in saliva, the reference electrode including at least one reference electrode protrusion; a middle plate which is disposed on the upper surface of the lower plate and which has a saliva inflow path perforated t[...]


Our summary: The invention describes a biosensor for measuring glucose concentration in saliva. It includes a lower plate with working and reference electrodes, a middle plate with a saliva inflow path, and an upper plate. The design ensures the working electrode s area covered by saliva is larger than that of the reference electrode.

Biosensor, glucose detection, saliva analysis, electrode design

Patent

Ethical and Clinical Best Practices for Genome Editing Applications

Published on 2026-02-02 by Mara Ortiz-Bueno, Federica Zinghirino, Pilar Puig Serra, Kyriaki Paschoudi, Lluis Montoliu, Erden Atilla, Yonglun Luo, Alessia Cavazza, Carsten W. Lederer, Karim Benabdellah @MDPI

Abstract: Genome editing (GE) has transformed medicine by allowing precise changes to DNA, offering potential treatments for a range of inherited and acquired disorders. Several technologies support these advances, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-based systems, of which the latter has emerged as the most accessible, versatile, and popular. While GE holds great promise, i[...]


Our summary: Genome editing technologies enable precise DNA modifications for medical treatments. Ethical and regulatory considerations are crucial for safe clinical applications. Regulatory agencies provide guidance on safety, consent, and compliance in genome editing practices.

Genome Editing, Ethical Standards, Regulatory Compliance, Clinical Applications

Publication

Bacillus velezensis Enhances Rice Resistance to Brown Spot by Integrating Antifungal and Growth Promotion Functions

Published on 2026-02-01 by Elizabeth B. E. Pires, Maira S. Tique Obando, Luis Janssen, Bergmann M. Ribeiro, Odaiza F. Souza, Marcelo L. Dias, Lus O. Viteri Jumbo, Rodrigo R. Fidelis, Gil R. Santos, Raimundo N. C. Rocha, Guy Smagghe, Tito Bacca, Eugenio E. Oliveira, Rudolf Haumann, Raimundo W. S. Aguiar @MDPI

Abstract: Brown spot, caused by the seedborne fungus Bipolaris oryzae, remains a major constraint in rice production. Here, we used in vitro and in vivo assays to evaluate the biocontrol potential of three Bacillus strains (Ba. cereus OQ725688.1, Ba. velezensis OP938696.1, and Ba. subtilis OP937353.1) against Bi. oryzae in two rice cultivars (&amp;ldquo;Rubelita&amp;rdquo; and &amp;ldquo;Predileta&amp;rdquo;). Ba. cereus showed the highest in vitro mycelial inhibition (&amp;asymp;95%),[...]


Our summary: Bacillus velezensis enhances rice resistance to brown spot by integrating antifungal and growth promotion functions. It effectively reduces disease severity and increases seedling vigor compared to infected controls. The strain exhibits unique biochemical traits and potential for sustainable rice protection strategies.

Bacillus velezensis, biocontrol, rice resistance, antifungal

Publication

Tópicos abordados: Biologia sintética, engenharia, biologia molecular, componentes genéticos, circuitos genéticos sintéticos, metabolismo celular, edição genômica, síntese de DNA, otimização de vias metabólicas, terapêutica, biocombustíveis, biossensores, biofabricação, sistemas ortogonais, células mínimas, redes regulatórias sintéticas, ISO 22174, ISO 16140, ISO 20391, ISO 13485 e ASTM E2875.

Glossário de termos utilizados

Deoxyribonucleic Acid (DNA): Uma molécula composta por duas cadeias que formam uma dupla hélice, constituída por nucleotídeos que codificam informações genéticas através de sequências de quatro bases: adenina, timina, citosina e guanina. Ela serve como material hereditário na maioria dos organismos vivos.

Contexto histórico

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(Caso a data seja desconhecida ou irrelevante, por exemplo, "mecânica dos fluidos", é fornecida uma estimativa aproximada de seu surgimento notável)

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