يدمج علم الأحياء التركيبي مبادئ الهندسة وعلم الأحياء الجزيئي لتصميم وبناء وتعديل الأنظمة البيولوجية ذات الوظائف الجديدة. ويشمل ذلك تجميع أجزاء جينية موحدة، وبناء دوائر جينية تركيبية، وإعادة برمجة عمليات الأيض الخلوي لإنشاء كائنات حية أو مكونات بيولوجية مصممة خصيصًا. تتضمن التقنيات تحرير الجينوم، وتخليق الحمض النووي، وتحسين المسارات الحيوية لتطوير تطبيقات في العلاجات، والوقود الحيوي، والاستشعار الحيوي، والتصنيع الحيوي. يُسهم هذا المجال في تعزيز فهم التعقيد البيولوجي من خلال إنشاء أنظمة متعامدة، وخلايا مصغرة، وشبكات تنظيمية تركيبية. يُقدم هذا التقرير مجموعة من المنشورات وبراءات الاختراع الحديثة التي تُفصّل الابتكارات في الأدوات والمنهجيات والتطبيقات ضمن علم الأحياء التركيبي.
هذه هي أحدث مجموعة مختارة من المنشورات وبراءات الاختراع في جميع أنحاء العالم باللغة الإنجليزية حول البيولوجيا التركيبية، بين العديد من المجلات العلمية على الإنترنت، مصنفة ومركزة على دائرة الجينات، هندسة التمثيل الغذائي، تركيب الحمض النووي، تحرير الجينوم، كريسبر كاس 9، الجينوم الاصطناعي، الجينوم الاصطناعي، البايوبريك، الأجزاء الوراثية، هندسة البروتين، تشاسي الخلية، المستشعر الحيوي، تحسين المسار, التحكم في التعبير الجيني، والمروج الاصطناعي، وجهاز الحمض النووي الريبي (RNA)، والخلية الصغرى، والنظام المتعامد، ومفتاح التبديل الجيني، والأوبرا الاصطناعية، والمسار الأيضي، والتطور الموجه، والشبكة التنظيمية الاصطناعية، وتجميع الحمض النووي الاصطناعي، والنظام الخالي من الخلايا، والنسخ الاصطناعي، وتوسيع الشفرة الوراثية، والبيولوجيا الاصطناعية، وتحليل التدفق الأيضي، والجين الاصطناعي، واستراتيجية الاحتواء الحيوي.
Electrode, biosensor, and electrode manufacturing method
Patent published on the 2026-07-02 in WO under Ref WO2026140553 by NITTO DENKO CORP [JP] (Fukuda Keita [jp], Yamashita Takayuki [jp], Kamano Yusuke [jp])
Abstract: This electrode comprises a substrate film and a conductive carbon layer in this order toward one side in the thickness direction. The electrode satisfies expression. Expression: 0.30[...]
Our summary: This content discusses an electrode that consists of a substrate film and a conductive carbon layer. It highlights a specific manufacturing method for the electrode. The electrode meets a defined expression value of 0.30.
Electrode, biosensor, conductive carbon, substrate film
Patent
Systems and methods for estrogen biosensing
Patent published on the 2026-06-25 in US under Ref US20260176666 by BIOSENS8 INC [US] (Kuzmanovic Uros [us], Charles Jr Roger J [us], Davis Connor A [us])
Abstract: The present disclosure generally relates to enzyme-based biosensors and, in particular, to biosensors for determining estrogen and other biomolecules. In some cases, the enzymes may be based on dehydrogenases, such as 17-beta hydroxysteroid dehydrogenases. In certain embodiments, the enzyme may include an active site that is able to bind to and oxidize estrogen, or other biomolecules. In some cases, the active site may include certain residues positioned around the active site that are able to s[...]
Our summary: The disclosure describes enzyme-based biosensors for detecting estrogen and other biomolecules. It focuses on dehydrogenases that oxidize estrogen through specific active sites. Methods for creating and utilizing these biosensors and related kits are also discussed.
biosensors, estrogen, dehydrogenases, enzyme-based
Patent
Expanded metabolic pathway for androgen production by commensal bacteria
Patent published on the 2026-06-25 in US under Ref US20260177553 by THE BRD OF TRUSTEES OF THE UNIV OF ILLINOIS [US] (Ridlon Jason M [us])
Abstract: [0000] Provided herein is the first commensal microbial gene encoding an enzyme that catalyzes the conversion of androstenedione to epitestosterone in the gut bacterium Clostridium scindens (desF). Also provided is an important and unrecognized capability for epitestosterone in androgen receptor-dependent prostate cancer cell proliferation and the potential clinical relevance of this bacterial enzymatic pathway (desF) in prostate cancer. Additionally, it was discovered that bacterial isolates fr[...]
Our summary: A novel microbial gene (desF) in Clostridium scindens converts androstenedione to epitestosterone. This pathway is linked to prostate cancer cell proliferation. Additionally, urinary isolates demonstrate the ability to produce androgens through the enzyme 17β-hydroxysteroid dehydrogenase (desG).
androgen production, commensal bacteria, Clostridium scindens, prostate cancer
Patent
Biosensor device
Patent published on the 2026-06-18 in WO under Ref WO2026127530 by WISOL CO LTD [KR] (Kim Jung Min [kr], Lee Ho Sub [kr])
Abstract: A biosensor device according to the present invention comprises: a printed circuit board in which at least one sample seating hole for seating a test sample is formed to have a hollow structure; a biosensor which is coupled to a position corresponding to the sample seating hole on the lower surface of the printed circuit board, and senses a sample reaction of the test sample; and a case having an inner space for accommodating the printed circuit board.[...]
Our summary: The biosensor device features a printed circuit board with a hollow sample seating hole. It includes a biosensor positioned beneath the hole to detect sample reactions. The device is housed in a case that accommodates the printed circuit board.
biosensor, printed circuit board, sample seating hole, test sample
Patent
Human cell-free system for high-throughput screening for new compounds for targeted protein degradation
Patent published on the 2026-06-17 in EP under Ref EP4759936 by FRAUNHOFER GES FORSCHUNG [DE] (Hahnengress Nils [de], Buntru Matthias [de])
Abstract: The present invention relates to a cell lysate wherein the lysis buffer comprises at least one of magnesium acetate, phosphorylation inhibitor K3L, an agonist of dephosphorylation GADD34 and/or a caspase inhibitor for use in, or as, a cell-free system and a method for preparing a cell-free protein synthesis system. Further provided is a method for expressing a protein in the cell-free protein synthesis system, a method for screening for a candidate compound for an effect on a target molecule and[...]
Our summary: The invention describes a human cell-free system for high-throughput screening of compounds targeting protein degradation. It includes a cell lysate with specific components for enhanced protein synthesis. Additionally, methods for expressing proteins and screening candidate compounds are provided, along with a related kit.
cell-free system, high-throughput screening, targeted protein degradation, protein synthesis
Patent
Spot drops biosensor nutrient management
Patent published on the 2026-06-11 in WO under Ref WO2026122877 by SOUTH DAKOTA BOARD OF REGENTS [US] (Khalid Ahmed [us], Mirzaee Salman [us], Mirzakhani Nafchi Ali [us], Kumari Karishma [us])
Abstract: Disclosed herein are methods and systems of detecting nutrient deficiencies in an agricultural field and creating a variable rate fertilizer application map by analyzing a field for standard vegetation markers, creating a management zone map having management zones based on the standard vegetation markers, wherein the management zones are assigned based on commonality in the standard vegetation markers. Applying a standard nutrient fertilizer to the field, assigning a plurality of biosensor rich[...]
Our summary: The system detects nutrient deficiencies in agricultural fields using biosensors. It creates a variable rate fertilizer application map based on vegetation markers and management zones. Fertilizer is applied variably using controlled spray nozzles to optimize yield.
biosensor, nutrient management, variable rate application, agricultural technology
Patent
Ethical and Clinical Best Practices for Genome Editing Applications
Published on 2026-02-02 by Mara Ortiz-Bueno, Federica Zinghirino, Pilar Puig Serra, Kyriaki Paschoudi, Lluis Montoliu, Erden Atilla, Yonglun Luo, Alessia Cavazza, Carsten W. Lederer, Karim Benabdellah @MDPI
Abstract: Genome editing (GE) has transformed medicine by allowing precise changes to DNA, offering potential treatments for a range of inherited and acquired disorders. Several technologies support these advances, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-based systems, of which the latter has emerged as the most accessible, versatile, and popular. While GE holds great promise, i[...]
Our summary: Genome editing technologies enable precise DNA modifications for medical treatments. Ethical and regulatory considerations are crucial for safe clinical applications. Regulatory agencies provide guidance on safety, consent, and compliance in genome editing practices.
Genome Editing, Ethical Standards, Regulatory Compliance, Clinical Applications
Publication
Bacillus velezensis Enhances Rice Resistance to Brown Spot by Integrating Antifungal and Growth Promotion Functions
Published on 2026-02-01 by Elizabeth B. E. Pires, Maira S. Tique Obando, Luis Janssen, Bergmann M. Ribeiro, Odaiza F. Souza, Marcelo L. Dias, Lus O. Viteri Jumbo, Rodrigo R. Fidelis, Gil R. Santos, Raimundo N. C. Rocha, Guy Smagghe, Tito Bacca, Eugenio E. Oliveira, Rudolf Haumann, Raimundo W. S. Aguiar @MDPI
Abstract: Brown spot, caused by the seedborne fungus Bipolaris oryzae, remains a major constraint in rice production. Here, we used in vitro and in vivo assays to evaluate the biocontrol potential of three Bacillus strains (Ba. cereus OQ725688.1, Ba. velezensis OP938696.1, and Ba. subtilis OP937353.1) against Bi. oryzae in two rice cultivars (“Rubelita” and “Predileta”). Ba. cereus showed the highest in vitro mycelial inhibition (≈95%),[...]
Our summary: Bacillus velezensis enhances rice resistance to brown spot by integrating antifungal and growth promotion functions. It effectively reduces disease severity and increases seedling vigor compared to infected controls. The strain exhibits unique biochemical traits and potential for sustainable rice protection strategies.
Bacillus velezensis, biocontrol, rice resistance, antifungal
Publication
