ChemSpider Chemistry Database

ChemSpider Chemistry Database compared with SciFinder, Reaxys and PubChem
ChemSpider Chemistry Database	SciFinder	Reaxys	PubChem
Operator and access: ChemSpider is owned by the Royal Society of Chemistry and is free to use. Registered users can deposit structures and spectra, and expert review supports curation.	Operator and access: SciFinder is a product of CAS. The vendor page lists no price and offers a demo request, so access is arranged with the vendor.	Operator and access: Reaxys is an Elsevier product. The vendor page lists no price, and data delivery through MCP, API or flat file is sold as a separate license.	Operator and access: PubChem is run by the National Center for Biotechnology Information at the US National Library of Medicine. The web interface is free to use.
Content scope: The database links compound structures to properties and to more than 470 sources, with duplicates merged and links back to the originals. It supports text, structure and substructure search.	Content scope: SciFinder covers substances, reactions, literature, patents and regulatory information. It can be searched by structure, name, CAS Registry Number or spectra data.	Content scope: Reaxys states over 1 billion chemistry data points. They include reactions with conditions and procedures, substance properties and spectra, bioactivity, toxicity and ADME data, and patents.	Content scope: PubChem combines compound, substance and bioassay records from many contributing data sources into one resource.
Synthesis planning: ChemSpider offers SyntheticPages, where users publish reactions. It does not offer predicted routes on the pages consulted.	Synthesis planning: SciFinder gives real-time retrosynthesis predictions and suggests alternative reagents, steps and conditions. Routes can be tailored to cost, selectivity or speed.	Synthesis planning: Reaxys shows published and AI-predicted synthesis routes in one view, each with conditions, procedures and references.
Data reuse: Compound sets can be downloaded from search results. A full data dump is not available, and database rights are not waived, so the data cannot be treated as open.		Data reuse: Programmatic delivery is sold under a separate license from the main product.	Data reuse: Structures and datasets can be downloaded in bulk through FTP at no cost, and the data are listed as public domain.

ChemSpider Chemistry Database compared with SciFinder, Reaxys and PubChem

ChemSpider Chemistry Database

SciFinder

Reaxys

PubChem

Operator and access: ChemSpider is owned by the Royal Society of Chemistry and is free to use. Registered users can deposit structures and spectra, and expert review supports curation.

Operator and access: SciFinder is a product of CAS. The vendor page lists no price and offers a demo request, so access is arranged with the vendor.

Operator and access: Reaxys is an Elsevier product. The vendor page lists no price, and data delivery through MCP, API or flat file is sold as a separate license.

Operator and access: PubChem is run by the National Center for Biotechnology Information at the US National Library of Medicine. The web interface is free to use.

Content scope: The database links compound structures to properties and to more than 470 sources, with duplicates merged and links back to the originals. It supports text, structure and substructure search.

Content scope: SciFinder covers substances, reactions, literature, patents and regulatory information. It can be searched by structure, name, CAS Registry Number or spectra data.

Content scope: Reaxys states over 1 billion chemistry data points. They include reactions with conditions and procedures, substance properties and spectra, bioactivity, toxicity and ADME data, and patents.

Content scope: PubChem combines compound, substance and bioassay records from many contributing data sources into one resource.

Synthesis planning: ChemSpider offers SyntheticPages, where users publish reactions. It does not offer predicted routes on the pages consulted.

Synthesis planning: SciFinder gives real-time retrosynthesis predictions and suggests alternative reagents, steps and conditions. Routes can be tailored to cost, selectivity or speed.

Synthesis planning: Reaxys shows published and AI-predicted synthesis routes in one view, each with conditions, procedures and references.

Data reuse: Compound sets can be downloaded from search results. A full data dump is not available, and database rights are not waived, so the data cannot be treated as open.

Data reuse: Programmatic delivery is sold under a separate license from the main product.

Data reuse: Structures and datasets can be downloaded in bulk through FTP at no cost, and the data are listed as public domain.