Latest Publications & Patents on Biotechnology and CRISPR

  • This week: base editors, gene editing, CRISPR, clinical applications, HOXA1, Bronchial Epithelial, Cell Cycle Progression, p21/CDKN1A, CRISPR/Cas9, Aldehyde Dehydrogenase 1A1, Radiation Response, Redox Stress, GbSMXL8, Strigolactone Signaling Pathway, Cotton Fiber Elongation, Plant Growth, QTLs, Candidate Genes, Molecular Mechanism, Phosphatidylcholine, Cytidine Transferase, Lipid Droplet, Lipophagy, gene editing, nucleic acid cargo, PASTE, transposon-mediated gene editing, CRISPR-Cas, Engineered, Cascade, Complexes
  • August 3, 2025
CRISPR

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This is our latest selection of worldwide publications and patents in english on Biotechnology and CRISPR, between many scientific online journals, classified and focused on CRISPR, gene editing, gRNA, PAM sequence, DNA cleavage, Cas9 protein, genome editing, gene insertion and gene knockout.

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Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a

Patent published on the 2025-05-21 in EP under Ref EP4556567 by FELDAN BIO INC [CA] (Del'guidice Thomas [ca], Lepetit-stoffaes Jean-pascal [ca], Guay David [ca])

Abstract: The present description relates to methods for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell. The methods involve contacting the cell with the polypeptide cargo in the presence of a peptide shuttle agent at a concentration sufficient to increase the polypeptide cargo's transduction efficiency. Also described here are parameters that may be used in the rational design of such synthetic peptide shuttle agents, peptide shuttle ag[...]

Our summary: Methods for delivering polypeptide cargos using synthetic peptide shuttle agents to increase transduction efficiency in target eukaryotic cells. Parameters for rational design, shuttle agents satisfying design parameters, and compositions for delivering various polypeptide cargos are also discussed. Applications and targets for genome-editing NK cells for improved immunotherapy are included.

synthetic peptide, shuttle agents, polypeptide cargos, transduction efficiency

Patent

Genome editing of plant jaz genes for pathogen resistance and improved fiber quality and yield

Patent published on the 2025-03-06 in WO under Ref WO2025050099 by TEXAS TECH UNIV SYSTEM [US] (Rock Chris [us], Sukumaran Sunitha [us])

Abstract: Embodiments of the present disclosure pertain to a plant or seed that includes one or more altered JASMONATE-ZIM DOMAIN repressor (JAZ) genes. Additional embodiments of the present disclosure pertain to methods of altering one or more JAZ genes of a plant or seed by introducing one or more alterations to the one or more JAZ genes of the plant or seed. The altered plants and seeds of the present disclosure may exhibit one or more altered properties, such as jasmonic acid (JA) insensitivity, enhan[...]

Our summary: Genome editing of plant JAZ genes for pathogen resistance and improved fiber quality and yield. Altered plants and seeds with enhanced resistance to pathogens and insects, and improved fiber yield and quality.

Genome editing, Plant, JAZ genes, Pathogen resistance

Patent

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    Topics covered: Biotechnology, CRISPR, gene editing, gRNA, PAM sequence, DNA cleavage, Cas9 protein, genome editing, gene insertion, gene knockout, neural excitatory/inhibitory imbalance, therapeutic challenges, ISO 21571, ISO 9001, ISO 13485, ISO/IEC 17025, and ISO 15189..

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