长寿科学研究衰老和年龄相关衰退的生物学机制，重点关注细胞衰老、端粒动力学、表观遗传改变、线粒体功能和全身炎症。这一多学科领域整合了…… 分子生物学遗传学、药理学和生物信息学相结合，旨在寻找延长健康寿命和预期寿命的干预措施。研究涵盖衰老细胞清除剂、热量限制模拟物、干细胞疗法和表观遗传重编程，目标是延缓或逆转生理衰退。以下汇编了最新的同行评审出版物和专利，反映了衰老生物标志物、抗衰老药物以及针对基本衰老过程的转化研究方法的最新进展。
这是我们从众多在线科学期刊中挑选出的关于长寿科学的全球最新英文出版物和专利，内容分类并侧重于衰老、端粒、长寿科学、热量限制、自噬、线粒体功能障碍、表观遗传时钟、抗衰老保护剂、衰老细胞清除剂、干细胞疗法、氧化应激、DNA修复、蛋白质稳态、炎症性衰老、mTOR抑制、sirtuin、长寿基因、二甲双胍、雷帕霉素、细胞重编程、年龄相关疾病、衰老生物标志物、营养保健品、寿命延长、健康寿命、端粒酶激活、昼夜节律、糖基化、神经退行性疾病、适应性反应和表观遗传学。
Prophylactic and/or therapeutic agent for skin disorder
Patent published on the 2026-05-21 in WO under Ref WO2026105679 by UNIV HOKKAIDO NAT UNIV CORP [JP] (Fukumoto Takeshi [jp], Noma Ken-ichi [jp])
Abstract: Provided is a prophylactic and/or therapeutic agent for photodermatitis caused by light exposure. This prophylactic and/or therapeutic agent for a skin disorder caused by light exposure contains an inhibitor for cellular senescence-associated secretory phenotype factors (SASP factors) as an active ingredient. As a result of exploring responses to light exposure in melanocytes and comprehensively analyzing molecules that can be therapeutic target seeds related to the skin disorder, it was shown t[...]
Our summary: This content discusses a prophylactic and therapeutic agent for photodermatitis caused by light exposure. It highlights the role of SASP factors in cellular senescence in melanocytes after light exposure. The agent contains an inhibitor for SASP factors, which is effective in preventing and treating the skin disorder.
photodermatitis, SASP factors, cellular senescence, melanocytes
Patent
Accurate, computationally tractable, and patient-specific blood flow modeling to improve nanoparticle-based targeted drug delivery
Patent published on the 2026-05-21 in US under Ref US20260142040 by UNIV ILLINOIS [US] (Masud Arif [us], Goraya Shoaib A [us], Arif Mariam K [us])
Abstract: Systems and methods are provided to accurately model nanoparticle deposition in human or animal vasculature while reducing computational costs though a number of specific algorithmic improvements. These methods can be used to virtually evaluate the effects of variations in the nanoparticle configuration (e.g., size, geometry, binding target and/or affinity) and/or timing of delivery (e.g., relative to a patient s circadian rhythm), allowing those properties to be improved in order to increase th[...]
Our summary: This work presents methods for accurate blood flow modeling to enhance nanoparticle drug delivery. It focuses on reducing computational costs while allowing for patient-specific simulations. The approach enables evaluation of nanoparticle configurations and delivery timing to optimize therapeutic effects and minimize side effects.
blood flow modeling, nanoparticle delivery, computational algorithms, patient-specific simulations
Patent
A formulation for the treatment of endometriosis
Patent published on the 2026-05-14 in AU under Ref AU2024227667 by HONEY NEXUS PTY LTD (Honey Chantelle)
Abstract: The invention is a nutraceutical formulation for the treatment of endometriosis symptoms in women. The invention is a nutraceutical formulation for the treatment of endometriosis symptoms in women. ct c t w o m e n[...]
Our summary: The invention is a nutraceutical formulation designed to alleviate endometriosis symptoms. It specifically targets women suffering from this condition. The formulation aims to improve the quality of life for affected individuals.
nutraceutical, formulation, endometriosis, treatment
Patent
Stimulation of the gut microbiota to produce vitamins
Patent published on the 2026-05-14 in AU under Ref AU2024372210 by AAK AB PUBL (Smolders Lotte, Olofsson Kim, Johansson Martin, Hartog Anita)
Abstract: The invention relates to the non-therapeutic use of one or more lipids to stimulate gut microbiota to produce certain vitamins. The invention also relates to nutraceutical products comprising one or more lipids for stimulating the gut microbiota to produce certain vitamins. Lipids of particular interest are lauric acid (C12:0), oleic acid (C18:1), linoleic acid (C18:2). Vitamins of particular interest are riboflavin and pyridoxamine.[...]
Our summary: The invention utilizes lipids to stimulate gut microbiota for vitamin production. Key lipids include lauric acid, oleic acid, and linoleic acid. Targeted vitamins are riboflavin and pyridoxamine, forming the basis of nutraceutical products.
gut microbiota, lipids, vitamins, nutraceuticals
Patent
Stimulation of the gut microbiota to produce amino acids
Patent published on the 2026-05-14 in AU under Ref AU2024369492 by AAK AB PUBL (Smolders Lotte, Olofsson Kim, Johansson Martin, Hartog Anita)
Abstract: The invention relates to the non-therapeutic use of one or more lipids to stimulate the gut microbiota to produce amino acids. The invention also relates to nutraceutical products comprising one or more lipids for stimulating the gut microbiota to produce amino acids. Lipids of particular interest are lauric acid (C12:0), capric acid (C10:0), oleic acid (C18:1) and linoleic acid (C18:2), and amino acids of particular interest are ᵞ-aminobutyric acid (GABA) and beta-alanine.[...]
Our summary: The invention utilizes lipids to stimulate gut microbiota for amino acid production. Specific lipids include lauric, capric, oleic, and linoleic acids. It also involves nutraceutical products targeting amino acids like GABA and beta-alanine.
gut microbiota, amino acids, lipids, nutraceuticals
Patent
Ophthalmic formulations comprising magnesium ascorbyl phosphate
Patent published on the 2026-05-14 in AU under Ref AU2024378238 by BAUSCH LOMB IRELAND LTD (Coffey Martin, Marlowe Zora, Vandermeid Karl)
Abstract: The present disclosure describes ophthalmic formulations comprising magnesium ascorbyl phosphate (MAP) for treating, improving, and/or ameliorating oxidative stress, symptoms thereof, or ocular diseases associated therewith, including ocular surface inflammation and dry eye disease.[...]
Our summary: The disclosure details ophthalmic formulations containing magnesium ascorbyl phosphate. These formulations aim to treat oxidative stress and associated ocular diseases. They specifically target conditions like ocular surface inflammation and dry eye disease.
ophthalmic formulations, magnesium ascorbyl phosphate, oxidative stress, dry eye disease
Patent
Capabilities and biophysical challenges at clinical 7T scanners
Published on 2026-04-09 by @MIT
Abstract: AbstractSub-millimeter resolution functional magnetic resonance imaging (fMRI) at ultra-high field (≥ 7T) has offered an unprecedented opportunity to probe mesoscopic computations at a columnar or laminar level. However, its application has been primarily restricted to the neocortex. Inferior brain regions, particularly the hippocampus (HC), are challenging targets for laminar fMRI. Recent developments in acquisition methods have shown the feasibility of laminar recordings in the HC using grad[...]
Our summary: This study explores the capabilities of 7T MRI for laminar fMRI in the hippocampus. It demonstrates the optimization of VASO to reduce venous bias and improve signal quality. The findings support the use of advanced acquisition methods to investigate memory retrieval mechanisms at a submillimeter resolution.
7T MRI, fMRI, VASO, hippocampus
Publication
Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter
Published on 2026-04-02 by @MIT
Abstract: AbstractThe retina is an optically accessible part of the central nervous system. Using high-resolution optical coherence tomography, we explored the relationship between retinal thickness and structural features of the brain obtained with magnetic resonance imaging. We hypothesized that there are associations between circumpapillary (i.e., around optic disc) retinal nerve fibre layer thickness and structural features of (i) brain areas and pathways related to visual information processing and ([...]
Our summary: Circumpapillary retinal nerve fibre layer thickness is associated with visual cortex grey matter density and optic radiation fractional anisotropy. Cardiovascular risk factors impact brain structure, but their correlation with retinal thickness was not significant. Further studies are needed to explore the relationship between eye and brain health in the context of neurodegenerative diseases.
retinal nerve fibre layer, brain structure, optical coherence tomography, cardiovascular risk factors
Publication
