长寿科学研究衰老和年龄相关衰退的生物学机制，重点关注细胞衰老、端粒动力学、表观遗传改变、线粒体功能和全身炎症。这一多学科领域整合了…… 分子生物学遗传学、药理学和生物信息学相结合，旨在寻找延长健康寿命和预期寿命的干预措施。研究涵盖衰老细胞清除剂、热量限制模拟物、干细胞疗法和表观遗传重编程，目标是延缓或逆转生理衰退。以下汇编了最新的同行评审出版物和专利，反映了衰老生物标志物、抗衰老药物以及针对基本衰老过程的转化研究方法的最新进展。
这是我们从众多在线科学期刊中挑选出的关于长寿科学的全球最新英文出版物和专利，内容分类并侧重于衰老、端粒、长寿科学、热量限制、自噬、线粒体功能障碍、表观遗传时钟、抗衰老保护剂、衰老细胞清除剂、干细胞疗法、氧化应激、DNA修复、蛋白质稳态、炎症性衰老、mTOR抑制、sirtuin、长寿基因、二甲双胍、雷帕霉素、细胞重编程、年龄相关疾病、衰老生物标志物、营养保健品、寿命延长、健康寿命、端粒酶激活、昼夜节律、糖基化、神经退行性疾病、适应性反应和表观遗传学。
Compositions and methods for adeno-associated (aav) virus dnase expression
Patent published on the 2026-05-28 in WO under Ref WO2026111749 by CLS THERAPEUTICS LLC [US] (Genkin Dmitry [us], Tetz George [us], Grant Logan [us], Ian Alexander [us])
Abstract: The invention relates to gene therapy, and more specifically, to AAV gene therapy vectors containing a novel chimeric deoxyribonuclease (DNase) protein transgene and methods of treating ailments such as cancer and neurodegeneration.[...]
Our summary: The invention involves AAV gene therapy vectors with a chimeric DNase protein transgene. It aims to treat conditions like cancer and neurodegeneration. The method enhances therapeutic efficacy through targeted gene delivery.
AAV, gene therapy, DNase, chimeric protein
Patent
Method for determining the sensitivity of a cancer to pd-1/pd-l1 therapy
Patent published on the 2026-05-28 in WO under Ref WO2026109721 by ASSIST PUBLIQUE HOPITAUX DE PARIS [FR] (Granier ClÉmence [fr], Paillaud Elena [fr], Gonnin CÉcile [fr])
Abstract: The present invention belongs to the field of disease therapy, and more specifically to the field of cancer therapy. In particular, the present invention belongs to a method for determining the sensitivity of a condition, preferably cancer, to a therapeutic agent and/or a method for determining whether a subject suffers from immune ageing and/or immunosenescence.[...]
Our summary: The invention provides a method to assess cancer sensitivity to PD-1/PD-L1 therapy. It focuses on determining the effectiveness of therapeutic agents for cancer treatment. Additionally, it evaluates whether a subject experiences immune aging or immunosenescence.
cancer therapy, PD-1, PD-L1, immune senescence
Patent
System and method for predictive modeling of cellular systems
Patent published on the 2026-05-28 in US under Ref US20260146990 by GEORGE MASON UNIV [US] (Kabbani Nadine [us], Sinclair Patricia [us], Jeffries William [us])
Abstract: [0000] A system and method for predictive modeling of cellular systems assesses compound effectiveness on cellular metabolic and inflammatory states. Cellular samples are exposed to metabolic MRX sensors detecting oxidative stress, reporting cytoskeletal organization, or monitoring mitochondrial morphology, dynamics, or compartment-specific redox activity. Images of MRX sensor-labeled samples are captured using an imaging device and analyzed by trained predictive models to determine compound imp[...]
Our summary: The system assesses compound effectiveness on cellular metabolic and inflammatory states. It utilizes metabolic MRX sensors and imaging devices to analyze cellular samples. Predictive models classify treatment conditions and enable compound ranking for drug screening and toxicity assessment.
predictive modeling, cellular systems, oxidative stress, drug screening
Patent
Lactococcus lactis subsp. lactis strain and its uses
Patent published on the 2026-05-27 in EP under Ref EP4748921 by NEA THEA 7 S L [ES] (GarcÍa MartÍn Elsa [es], De La Cruz SÁnchez Rebeca [es], MartÍn Diana Ana BelÉn [es], Rico Bargues Daniel [es], Requena Rolania Teresa [es], Olmo LÓpez RocÍo [es], MartÍn Quijada Narciso [es], Monte VÁzquez Enrique [es])
Abstract: The present invention relates to the strain Lactococcus lactis subsp. lactis CECT 31096, to its cellular components, metabolites, and secreted molecules, and to compositions comprising the above products, as well as to their uses as a medicament, preferably for the prevention and/or reduction of hypertension, or as a food composition or nutraceutical.[...]
Our summary: The invention focuses on Lactococcus lactis subsp. lactis CECT 31096 and its components. It highlights its potential uses in preventing or reducing hypertension. Additionally, it discusses applications in food compositions and nutraceuticals.
Lactococcus lactis, hypertension, metabolites, nutraceutical
Patent
Method for determining the sensitivity of a cancer to pd-1/pd-l1 therapy
Patent published on the 2026-05-27 in EP under Ref EP4749280 by HOPITAUX PARIS ASSIST PUBLIQUE [FR] (Granier ClÉmence [fr], Paillaud Elena [fr], Gonnin CÉcile [fr])
Abstract: [0001] The present invention belongs to the field of disease therapy, and more specifically to the field of cancer therapy. In particular, the present invention belongs to a method for determining the sensitivity of a condition, preferably cancer, to a therapeutic agent and/or a method for determining whether a subject suffers from immune ageing and/or immunosenescence.[...]
Our summary: This invention outlines a method to assess cancer sensitivity to PD-1/PD-L1 therapy. It focuses on determining whether a subject is affected by immune aging or immunosenescence. The method aims to enhance therapeutic effectiveness in cancer treatment.
cancer therapy, PD-1, PD-L1, sensitivity testing
Patent
Accurate, computationally tractable, and patient-specific blood flow modeling to improve nanoparticle-based targeted drug delivery
Patent published on the 2026-05-21 in US under Ref US20260142040 by UNIV ILLINOIS [US] (Masud Arif [us], Goraya Shoaib A [us], Arif Mariam K [us])
Abstract: Systems and methods are provided to accurately model nanoparticle deposition in human or animal vasculature while reducing computational costs though a number of specific algorithmic improvements. These methods can be used to virtually evaluate the effects of variations in the nanoparticle configuration (e.g., size, geometry, binding target and/or affinity) and/or timing of delivery (e.g., relative to a patient s circadian rhythm), allowing those properties to be improved in order to increase th[...]
Our summary: This work presents methods for accurate blood flow modeling to enhance nanoparticle drug delivery. It focuses on reducing computational costs while allowing for patient-specific simulations. The approach enables evaluation of nanoparticle configurations and delivery timing to optimize therapeutic effects and minimize side effects.
blood flow modeling, nanoparticle delivery, computational algorithms, patient-specific simulations
Patent
Capabilities and biophysical challenges at clinical 7T scanners
Published on 2026-04-09 by @MIT
Abstract: AbstractSub-millimeter resolution functional magnetic resonance imaging (fMRI) at ultra-high field (≥ 7T) has offered an unprecedented opportunity to probe mesoscopic computations at a columnar or laminar level. However, its application has been primarily restricted to the neocortex. Inferior brain regions, particularly the hippocampus (HC), are challenging targets for laminar fMRI. Recent developments in acquisition methods have shown the feasibility of laminar recordings in the HC using grad[...]
Our summary: This study explores the capabilities of 7T MRI for laminar fMRI in the hippocampus. It demonstrates the optimization of VASO to reduce venous bias and improve signal quality. The findings support the use of advanced acquisition methods to investigate memory retrieval mechanisms at a submillimeter resolution.
7T MRI, fMRI, VASO, hippocampus
Publication
Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter
Published on 2026-04-02 by @MIT
Abstract: AbstractThe retina is an optically accessible part of the central nervous system. Using high-resolution optical coherence tomography, we explored the relationship between retinal thickness and structural features of the brain obtained with magnetic resonance imaging. We hypothesized that there are associations between circumpapillary (i.e., around optic disc) retinal nerve fibre layer thickness and structural features of (i) brain areas and pathways related to visual information processing and ([...]
Our summary: Circumpapillary retinal nerve fibre layer thickness is associated with visual cortex grey matter density and optic radiation fractional anisotropy. Cardiovascular risk factors impact brain structure, but their correlation with retinal thickness was not significant. Further studies are needed to explore the relationship between eye and brain health in the context of neurodegenerative diseases.
retinal nerve fibre layer, brain structure, optical coherence tomography, cardiovascular risk factors
Publication
