长寿科学研究衰老和年龄相关衰退的生物学机制，重点关注细胞衰老、端粒动力学、表观遗传改变、线粒体功能和全身炎症。这一多学科领域整合了…… 分子生物学遗传学、药理学和生物信息学相结合，旨在寻找延长健康寿命和预期寿命的干预措施。研究涵盖衰老细胞清除剂、热量限制模拟物、干细胞疗法和表观遗传重编程，目标是延缓或逆转生理衰退。以下汇编了最新的同行评审出版物和专利，反映了衰老生物标志物、抗衰老药物以及针对基本衰老过程的转化研究方法的最新进展。
这是我们从众多在线科学期刊中挑选出的关于长寿科学的全球最新英文出版物和专利，内容分类并侧重于衰老、端粒、长寿科学、热量限制、自噬、线粒体功能障碍、表观遗传时钟、抗衰老保护剂、衰老细胞清除剂、干细胞疗法、氧化应激、DNA修复、蛋白质稳态、炎症性衰老、mTOR抑制、sirtuin、长寿基因、二甲双胍、雷帕霉素、细胞重编程、年龄相关疾病、衰老生物标志物、营养保健品、寿命延长、健康寿命、端粒酶激活、昼夜节律、糖基化、神经退行性疾病、适应性反应和表观遗传学。
Novel methods for lyophilized kefir-loaded self-nanoemulsifying delivery system of caraway oil and licorice extract on cognitive function via the micr
Patent published on the 2026-07-02 in US under Ref US20260183352 by UNIV OF SHARJAH [AE] (Anwar Mai Mamdouh [eg], Amin Amr [ae], Boseila Amira A [eg])
Abstract: Chronic inflammatory bowel disorders (IBDs) are characterized by altered intestinal permeability, prompting inflammatory, oxidative stress and immunological factors. Gut microbiota disorders impact brain function via the bidirectional gut-brain axis, influencing behavior through inflammatory cascades, oxidative stress, and neurotransmitter levels. The present invention comprises lyophilized milk kefir alone and lyophilized milk kefir as solid carriers loaded with self-nanoemulsifying self-nanosu[...]
Our summary: The invention presents a lyophilized kefir-loaded delivery system for caraway oil and licorice extract aimed at improving cognitive function. Daily administration restores body weight, reduces inflammation, and normalizes neurotransmitter levels. It also improves gut microbiota and alleviates symptoms associated with inflammatory bowel disorders.
self-nanoemulsifying, lyophilized kefir, cognitive function, inflammatory bowel disorders
Patent
New use of 1-amino-3,5-dimethyladamantane hydrochloride
Patent published on the 2026-07-02 in WO under Ref WO2026138307 by SHENZHEN EVERGREEN THERAPEUTICS CO LTD [CN] (Du Tao Tom [cn], Du Xin [cn], Li Shanshan [cn])
Abstract: New use of 1-amino-3,5-dimethyladamantane hydrochloride in treating or preventing cognitive impairment, reducing microglia in the cortex and hippocampus, reducing neuron loss in the cortex and hippocampus, and ameliorating the mitochondrial dysfunction state. The cognitive impairment includes cognitive impairment in systemic lupus erythematosus, Parkinson s disease, lateral sclerosis, stroke, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, attention deficit hyperactivity di[...]
Our summary: 1-amino-3,5-dimethyladamantane hydrochloride is used to treat cognitive impairment and prevent neuron loss. It reduces microglia in the cortex and hippocampus. The application includes a drug and treatment method for various cognitive disorders.
1-amino-3,5-dimethyladamantane, cognitive impairment, microglia reduction, mitochondrial dysfunction
Patent
Cosmetic composition for skin cell longevity
Patent published on the 2026-07-02 in WO under Ref WO2026139327 by LOREAL [FR] (Laboureau Julien [fr], Menasria Samy [fr], Ballihaut Carine [fr], Simonnet Jean-thierry [fr])
Abstract: The present invention relates to a composition comprising a combination of at least two cosmetic active agents, said combination of active agents preventing or reducing the loss of proteostasis, preventing or reducing micro-inflammatory processes, preventing cellular senescence, and preventing or reducing mitochondrial dysfunction and/or stimulating mitochondrial energy metabolism in skin cells The invention also relates to the cosmetic use of such a composition for increasing the longevity of s[...]
Our summary: The invention presents a cosmetic composition that combines at least two active agents to enhance skin cell longevity. It aims to prevent loss of proteostasis, micro-inflammatory processes, cellular senescence, and mitochondrial dysfunction. The composition is intended for topical application to improve the health of skin cells and tissues.
cosmetic composition, skin cell longevity, proteostasis, mitochondrial dysfunction
Patent
Latilactobacillus sakei strain and uses thereof
Patent published on the 2026-06-25 in WO under Ref WO2026131871 by UNIV NAVARRA [ES] (Aranaz Oroz Paula [es], Goyache Sarasa Ignacio [es], Virto Resano Raquel [es], ValdÉs Varela Lorena [es], Rodas MÉndez Ana Lucia [es], GonzÁlez Navarro Carlos Javier [es], Milagro Yoldi FermÍn [es])
Abstract: The present invention relates a new probiotic strain of the species Latilactobacillus sakei deposited at the "Colección Española de Cultivos Tipo (CECT)" under the accession number CECT 30971, or a variant of said strain, to compositions, pharmaceutical compositions or food products comprising said strain, and used thereof in the prevention and/or treatment of obesity and associated metabolic diseases, inflammation, and oxidative stress. The present invention also relates to a bacterial cultur[...]
Our summary: The invention introduces a new probiotic strain of Latilactobacillus sakei for use in compositions and food products. It targets the prevention and treatment of obesity, inflammation, and oxidative stress. Additionally, it encompasses bacterial cultures and postbiotic compositions derived from this strain.
Latilactobacillus sakei, probiotic strain, metabolic diseases, postbiotic composition
Patent
Functionally enhanced stem cells primed with prl-1 variant and therapeutic composition comprising same
Patent published on the 2026-06-25 in WO under Ref WO2026135379 by PLABIOLOGICS CO LTD [KR] (Lee Hyun Jung [kr], Jang Hyeon-jun [kr], Lee Hankyu [kr])
Abstract: The present invention relates to functionally enhanced stem cells and a therapeutic composition comprising same and, more specifically, to functionally enhanced stem cells primed with a PRL-1 variant and a composition for treating metabolic diseases, comprising the functionally enhanced stem cells. According to the present invention, functionally enhanced mesenchymal stem cells can be obtained without artificial gene introduction, and the mesenchymal stem cells functionally enhanced according to[...]
Our summary: Functionally enhanced stem cells are primed with a PRL-1 variant. The invention provides a therapeutic composition for treating metabolic diseases. Enhanced mesenchymal stem cells show increased growth and reduced senescence without artificial gene introduction.
stem cells, PRL-1 variant, therapeutic composition, metabolic diseases
Patent
Noni (morinda citrifolia) concentrate as an anti-diabetic nutraceutical
Patent published on the 2026-06-18 in US under Ref US20260166110 by NORTHERN MARIANAS COLLEGE [US] (Sarker Md Zaidul Islam [us], Coleman Patricia [us], Mia Md Abdur Rashid [us])
Abstract: [0000] A composition of noni (Morinda citrifolia) concentrate as an anti-diabetic nutraceutical prepared using supercritical carbon dioxide extraction. The anti-diabetic nutraceutical is in a form of supercritical carbon dioxide extract and has a strong α-glucosidase inhibition activity characterized by IClower than 50 μg/mL measured in vitro using isolated α-glucosidase enzyme. The extract is useful as anti-diabetic remedy with no acute or sub-acute toxicity and it also lowers blood total ch[...]
Our summary: Noni (Morinda citrifolia) concentrate is developed as an anti-diabetic nutraceutical using supercritical carbon dioxide extraction. It exhibits strong α-glucosidase inhibition activity with an IC lower than 50 μg/mL. The extract shows no toxicity and improves lipid profiles in diabetic mammals.
Noni, anti-diabetic, nutraceutical, supercritical extraction
Patent
Capabilities and biophysical challenges at clinical 7T scanners
Published on 2026-04-09 by @MIT
Abstract: AbstractSub-millimeter resolution functional magnetic resonance imaging (fMRI) at ultra-high field (≥ 7T) has offered an unprecedented opportunity to probe mesoscopic computations at a columnar or laminar level. However, its application has been primarily restricted to the neocortex. Inferior brain regions, particularly the hippocampus (HC), are challenging targets for laminar fMRI. Recent developments in acquisition methods have shown the feasibility of laminar recordings in the HC using grad[...]
Our summary: This study explores the capabilities of 7T MRI for laminar fMRI in the hippocampus. It demonstrates the optimization of VASO to reduce venous bias and improve signal quality. The findings support the use of advanced acquisition methods to investigate memory retrieval mechanisms at a submillimeter resolution.
7T MRI, fMRI, VASO, hippocampus
Publication
Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter
Published on 2026-04-02 by @MIT
Abstract: AbstractThe retina is an optically accessible part of the central nervous system. Using high-resolution optical coherence tomography, we explored the relationship between retinal thickness and structural features of the brain obtained with magnetic resonance imaging. We hypothesized that there are associations between circumpapillary (i.e., around optic disc) retinal nerve fibre layer thickness and structural features of (i) brain areas and pathways related to visual information processing and ([...]
Our summary: Circumpapillary retinal nerve fibre layer thickness is associated with visual cortex grey matter density and optic radiation fractional anisotropy. Cardiovascular risk factors impact brain structure, but their correlation with retinal thickness was not significant. Further studies are needed to explore the relationship between eye and brain health in the context of neurodegenerative diseases.
retinal nerve fibre layer, brain structure, optical coherence tomography, cardiovascular risk factors
Publication
