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Dernières publications et brevets sur la science de la longévité

Science de la longévité

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La science de la longévité
Advancements in longevity science aim to enhance healthspan and durée de vie through innovative interventions targeting the biological mechanisms of aging.

Longevity Science investigates the biological mechanisms underlying aging and age-related decline, focusing on cellular senescence, telomere dynamics, epigenetic alterations, mitochondrial function, and systemic inflammation. This multidisciplinary field integrates biologie moléculaire, genetics, pharmacology, and bioinformatics to identify interventions that extend healthspan and lifespan. Research spans senolytic compounds, caloric restriction mimetics, stem cell therapies, and epigenetic reprogramming, aiming to delay or reverse physiological deterioration. The following compilation presents the latest peer-reviewed publications and patents, reflecting advances in biomarkers of aging, geroprotective agents, and translational approaches targeting fundamental aging processes.

Voici notre dernière sélection de publications et brevets mondiaux en anglais sur la science de la longévité, parmi de nombreuses revues scientifiques en ligne, classifiés et axés sur la sénescence, le télomère, la science de la longévité, la restriction calorique, l'autophagie, le dysfonctionnement mitochondrial, l'horloge épigénétique, le géroprotecteur, le sénolytique, la thérapie par cellules souches, le stress oxydatif, la réparation de l'ADN, la protéostase, l'inflammaging, l'inhibition de mTOR, la sirtuine, les gènes de longévité, la metformine, la rapamycine, la reprogrammation cellulaire, les maladies liées à l'âge, les biomarqueurs du vieillissement, les nutraceutiques, l'extension de la durée de vie, la durée de vie en bonne santé, l'activation de la télomérase, le rythme circadien, la glycation, la neurodégénérescence, l'hormèse et l'épigénétique.

Compositions and methods for adeno-associated (aav) virus dnase expression

Patent published on the 2026-05-28 in WO under Ref WO2026111749 by CLS THERAPEUTICS LLC [US] (Genkin Dmitry [us], Tetz George [us], Grant Logan [us], Ian Alexander [us])

Abstract: The invention relates to gene therapy, and more specifically, to AAV gene therapy vectors containing a novel chimeric deoxyribonuclease (DNase) protein transgene and methods of treating ailments such as cancer and neurodegeneration.[...]


Our summary: The invention involves AAV gene therapy vectors with a chimeric DNase protein transgene. It aims to treat conditions like cancer and neurodegeneration. The method enhances therapeutic efficacy through targeted gene delivery.

AAV, gene therapy, DNase, chimeric protein

Patent

Method for determining the sensitivity of a cancer to pd-1/pd-l1 therapy

Patent published on the 2026-05-28 in WO under Ref WO2026109721 by ASSIST PUBLIQUE HOPITAUX DE PARIS [FR] (Granier ClÉmence [fr], Paillaud Elena [fr], Gonnin CÉcile [fr])

Abstract: The present invention belongs to the field of disease therapy, and more specifically to the field of cancer therapy. In particular, the present invention belongs to a method for determining the sensitivity of a condition, preferably cancer, to a therapeutic agent and/or a method for determining whether a subject suffers from immune ageing and/or immunosenescence.[...]


Our summary: The invention provides a method to assess cancer sensitivity to PD-1/PD-L1 therapy. It focuses on determining the effectiveness of therapeutic agents for cancer treatment. Additionally, it evaluates whether a subject experiences immune aging or immunosenescence.

cancer therapy, PD-1, PD-L1, immune senescence

Patent

System and method for predictive modeling of cellular systems

Patent published on the 2026-05-28 in US under Ref US20260146990 by GEORGE MASON UNIV [US] (Kabbani Nadine [us], Sinclair Patricia [us], Jeffries William [us])

Abstract: [0000] A system and method for predictive modeling of cellular systems assesses compound effectiveness on cellular metabolic and inflammatory states. Cellular samples are exposed to metabolic MRX sensors detecting oxidative stress, reporting cytoskeletal organization, or monitoring mitochondrial morphology, dynamics, or compartment-specific redox activity. Images of MRX sensor-labeled samples are captured using an imaging device and analyzed by trained predictive models to determine compound imp[...]


Our summary: The system assesses compound effectiveness on cellular metabolic and inflammatory states. It utilizes metabolic MRX sensors and imaging devices to analyze cellular samples. Predictive models classify treatment conditions and enable compound ranking for drug screening and toxicity assessment.

predictive modeling, cellular systems, oxidative stress, drug screening

Patent

Lactococcus lactis subsp. lactis strain and its uses

Patent published on the 2026-05-27 in EP under Ref EP4748921 by NEA THEA 7 S L [ES] (GarcÍa MartÍn Elsa [es], De La Cruz SÁnchez Rebeca [es], MartÍn Diana Ana BelÉn [es], Rico Bargues Daniel [es], Requena Rolania Teresa [es], Olmo LÓpez RocÍo [es], MartÍn Quijada Narciso [es], Monte VÁzquez Enrique [es])

Abstract: The present invention relates to the strain Lactococcus lactis subsp. lactis CECT 31096, to its cellular components, metabolites, and secreted molecules, and to compositions comprising the above products, as well as to their uses as a medicament, preferably for the prevention and/or reduction of hypertension, or as a food composition or nutraceutical.[...]


Our summary: The invention focuses on Lactococcus lactis subsp. lactis CECT 31096 and its components. It highlights its potential uses in preventing or reducing hypertension. Additionally, it discusses applications in food compositions and nutraceuticals.

Lactococcus lactis, hypertension, metabolites, nutraceutical

Patent

Method for determining the sensitivity of a cancer to pd-1/pd-l1 therapy

Patent published on the 2026-05-27 in EP under Ref EP4749280 by HOPITAUX PARIS ASSIST PUBLIQUE [FR] (Granier ClÉmence [fr], Paillaud Elena [fr], Gonnin CÉcile [fr])

Abstract: [0001] The present invention belongs to the field of disease therapy, and more specifically to the field of cancer therapy. In particular, the present invention belongs to a method for determining the sensitivity of a condition, preferably cancer, to a therapeutic agent and/or a method for determining whether a subject suffers from immune ageing and/or immunosenescence.[...]


Our summary: This invention outlines a method to assess cancer sensitivity to PD-1/PD-L1 therapy. It focuses on determining whether a subject is affected by immune aging or immunosenescence. The method aims to enhance therapeutic effectiveness in cancer treatment.

cancer therapy, PD-1, PD-L1, sensitivity testing

Patent

Accurate, computationally tractable, and patient-specific blood flow modeling to improve nanoparticle-based targeted drug delivery

Patent published on the 2026-05-21 in US under Ref US20260142040 by UNIV ILLINOIS [US] (Masud Arif [us], Goraya Shoaib A [us], Arif Mariam K [us])

Abstract: Systems and methods are provided to accurately model nanoparticle deposition in human or animal vasculature while reducing computational costs though a number of specific algorithmic improvements. These methods can be used to virtually evaluate the effects of variations in the nanoparticle configuration (e.g., size, geometry, binding target and/or affinity) and/or timing of delivery (e.g., relative to a patient s circadian rhythm), allowing those properties to be improved in order to increase th[...]


Our summary: This work presents methods for accurate blood flow modeling to enhance nanoparticle drug delivery. It focuses on reducing computational costs while allowing for patient-specific simulations. The approach enables evaluation of nanoparticle configurations and delivery timing to optimize therapeutic effects and minimize side effects.

blood flow modeling, nanoparticle delivery, computational algorithms, patient-specific simulations

Patent

Capabilities and biophysical challenges at clinical 7T scanners

Published on 2026-04-09 by @MIT

Abstract: AbstractSub-millimeter resolution functional magnetic resonance imaging (fMRI) at ultra-high field (≥ 7T) has offered an unprecedented opportunity to probe mesoscopic computations at a columnar or laminar level. However, its application has been primarily restricted to the neocortex. Inferior brain regions, particularly the hippocampus (HC), are challenging targets for laminar fMRI. Recent developments in acquisition methods have shown the feasibility of laminar recordings in the HC using grad[...]


Our summary: This study explores the capabilities of 7T MRI for laminar fMRI in the hippocampus. It demonstrates the optimization of VASO to reduce venous bias and improve signal quality. The findings support the use of advanced acquisition methods to investigate memory retrieval mechanisms at a submillimeter resolution.

7T MRI, fMRI, VASO, hippocampus

Publication

Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter

Published on 2026-04-02 by @MIT

Abstract: AbstractThe retina is an optically accessible part of the central nervous system. Using high-resolution optical coherence tomography, we explored the relationship between retinal thickness and structural features of the brain obtained with magnetic resonance imaging. We hypothesized that there are associations between circumpapillary (i.e., around optic disc) retinal nerve fibre layer thickness and structural features of (i) brain areas and pathways related to visual information processing and ([...]


Our summary: Circumpapillary retinal nerve fibre layer thickness is associated with visual cortex grey matter density and optic radiation fractional anisotropy. Cardiovascular risk factors impact brain structure, but their correlation with retinal thickness was not significant. Further studies are needed to explore the relationship between eye and brain health in the context of neurodegenerative diseases.

retinal nerve fibre layer, brain structure, optical coherence tomography, cardiovascular risk factors

Publication

Sujets abordés : Science de la longévité, durée de vie en bonne santé, durée de vie, mécanismes biologiques, sénescence cellulaire, dynamique des télomères, altérations épigénétiques, fonction mitochondriale, inflammation systémique, biologie moléculaire, génétique, pharmacologie, bioinformatique, composés sénolytiques, mimétiques de la restriction calorique, thérapies par cellules souches, reprogrammation épigénétique, biomarqueurs du vieillissement, agents géroprotecteurs ISO 22118, ISO 22120, ISO 22000, ISO 9001 et ISO 14001.

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