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Dernières publications et brevets sur la science de la longévité

Science de la longévité

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La science de la longévité
Advancements in longevity science aim to enhance healthspan and durée de vie through innovative interventions targeting the biological mechanisms of aging.

Longevity Science investigates the biological mechanisms underlying aging and age-related decline, focusing on cellular senescence, telomere dynamics, epigenetic alterations, mitochondrial function, and systemic inflammation. This multidisciplinary field integrates biologie moléculaire, genetics, pharmacology, and bioinformatics to identify interventions that extend healthspan and lifespan. Research spans senolytic compounds, caloric restriction mimetics, stem cell therapies, and epigenetic reprogramming, aiming to delay or reverse physiological deterioration. The following compilation presents the latest peer-reviewed publications and patents, reflecting advances in biomarkers of aging, geroprotective agents, and translational approaches targeting fundamental aging processes.

Voici notre dernière sélection de publications et brevets mondiaux en anglais sur la science de la longévité, parmi de nombreuses revues scientifiques en ligne, classifiés et axés sur la sénescence, le télomère, la science de la longévité, la restriction calorique, l'autophagie, le dysfonctionnement mitochondrial, l'horloge épigénétique, le géroprotecteur, le sénolytique, la thérapie par cellules souches, le stress oxydatif, la réparation de l'ADN, la protéostase, l'inflammaging, l'inhibition de mTOR, la sirtuine, les gènes de longévité, la metformine, la rapamycine, la reprogrammation cellulaire, les maladies liées à l'âge, les biomarqueurs du vieillissement, les nutraceutiques, l'extension de la durée de vie, la durée de vie en bonne santé, l'activation de la télomérase, le rythme circadien, la glycation, la neurodégénérescence, l'hormèse et l'épigénétique.

Prophylactic and/or therapeutic agent for skin disorder

Patent published on the 2026-05-21 in WO under Ref WO2026105679 by UNIV HOKKAIDO NAT UNIV CORP [JP] (Fukumoto Takeshi [jp], Noma Ken-ichi [jp])

Abstract: Provided is a prophylactic and/or therapeutic agent for photodermatitis caused by light exposure. This prophylactic and/or therapeutic agent for a skin disorder caused by light exposure contains an inhibitor for cellular senescence-associated secretory phenotype factors (SASP factors) as an active ingredient. As a result of exploring responses to light exposure in melanocytes and comprehensively analyzing molecules that can be therapeutic target seeds related to the skin disorder, it was shown t[...]


Our summary: This content discusses a prophylactic and therapeutic agent for photodermatitis caused by light exposure. It highlights the role of SASP factors in cellular senescence in melanocytes after light exposure. The agent contains an inhibitor for SASP factors, which is effective in preventing and treating the skin disorder.

photodermatitis, SASP factors, cellular senescence, melanocytes

Patent

Accurate, computationally tractable, and patient-specific blood flow modeling to improve nanoparticle-based targeted drug delivery

Patent published on the 2026-05-21 in US under Ref US20260142040 by UNIV ILLINOIS [US] (Masud Arif [us], Goraya Shoaib A [us], Arif Mariam K [us])

Abstract: Systems and methods are provided to accurately model nanoparticle deposition in human or animal vasculature while reducing computational costs though a number of specific algorithmic improvements. These methods can be used to virtually evaluate the effects of variations in the nanoparticle configuration (e.g., size, geometry, binding target and/or affinity) and/or timing of delivery (e.g., relative to a patient s circadian rhythm), allowing those properties to be improved in order to increase th[...]


Our summary: This work presents methods for accurate blood flow modeling to enhance nanoparticle drug delivery. It focuses on reducing computational costs while allowing for patient-specific simulations. The approach enables evaluation of nanoparticle configurations and delivery timing to optimize therapeutic effects and minimize side effects.

blood flow modeling, nanoparticle delivery, computational algorithms, patient-specific simulations

Patent

A formulation for the treatment of endometriosis

Patent published on the 2026-05-14 in AU under Ref AU2024227667 by HONEY NEXUS PTY LTD (Honey Chantelle)

Abstract: The invention is a nutraceutical formulation for the treatment of endometriosis symptoms in women. The invention is a nutraceutical formulation for the treatment of endometriosis symptoms in women. ct c t w o m e n[...]


Our summary: The invention is a nutraceutical formulation designed to alleviate endometriosis symptoms. It specifically targets women suffering from this condition. The formulation aims to improve the quality of life for affected individuals.

nutraceutical, formulation, endometriosis, treatment

Patent

Stimulation of the gut microbiota to produce vitamins

Patent published on the 2026-05-14 in AU under Ref AU2024372210 by AAK AB PUBL (Smolders Lotte, Olofsson Kim, Johansson Martin, Hartog Anita)

Abstract: The invention relates to the non-therapeutic use of one or more lipids to stimulate gut microbiota to produce certain vitamins. The invention also relates to nutraceutical products comprising one or more lipids for stimulating the gut microbiota to produce certain vitamins. Lipids of particular interest are lauric acid (C12:0), oleic acid (C18:1), linoleic acid (C18:2). Vitamins of particular interest are riboflavin and pyridoxamine.[...]


Our summary: The invention utilizes lipids to stimulate gut microbiota for vitamin production. Key lipids include lauric acid, oleic acid, and linoleic acid. Targeted vitamins are riboflavin and pyridoxamine, forming the basis of nutraceutical products.

gut microbiota, lipids, vitamins, nutraceuticals

Patent

Stimulation of the gut microbiota to produce amino acids

Patent published on the 2026-05-14 in AU under Ref AU2024369492 by AAK AB PUBL (Smolders Lotte, Olofsson Kim, Johansson Martin, Hartog Anita)

Abstract: The invention relates to the non-therapeutic use of one or more lipids to stimulate the gut microbiota to produce amino acids. The invention also relates to nutraceutical products comprising one or more lipids for stimulating the gut microbiota to produce amino acids. Lipids of particular interest are lauric acid (C12:0), capric acid (C10:0), oleic acid (C18:1) and linoleic acid (C18:2), and amino acids of particular interest are ᵞ-aminobutyric acid (GABA) and beta-alanine.[...]


Our summary: The invention utilizes lipids to stimulate gut microbiota for amino acid production. Specific lipids include lauric, capric, oleic, and linoleic acids. It also involves nutraceutical products targeting amino acids like GABA and beta-alanine.

gut microbiota, amino acids, lipids, nutraceuticals

Patent

Ophthalmic formulations comprising magnesium ascorbyl phosphate

Patent published on the 2026-05-14 in AU under Ref AU2024378238 by BAUSCH LOMB IRELAND LTD (Coffey Martin, Marlowe Zora, Vandermeid Karl)

Abstract: The present disclosure describes ophthalmic formulations comprising magnesium ascorbyl phosphate (MAP) for treating, improving, and/or ameliorating oxidative stress, symptoms thereof, or ocular diseases associated therewith, including ocular surface inflammation and dry eye disease.[...]


Our summary: The disclosure details ophthalmic formulations containing magnesium ascorbyl phosphate. These formulations aim to treat oxidative stress and associated ocular diseases. They specifically target conditions like ocular surface inflammation and dry eye disease.

ophthalmic formulations, magnesium ascorbyl phosphate, oxidative stress, dry eye disease

Patent

Capabilities and biophysical challenges at clinical 7T scanners

Published on 2026-04-09 by @MIT

Abstract: AbstractSub-millimeter resolution functional magnetic resonance imaging (fMRI) at ultra-high field (≥ 7T) has offered an unprecedented opportunity to probe mesoscopic computations at a columnar or laminar level. However, its application has been primarily restricted to the neocortex. Inferior brain regions, particularly the hippocampus (HC), are challenging targets for laminar fMRI. Recent developments in acquisition methods have shown the feasibility of laminar recordings in the HC using grad[...]


Our summary: This study explores the capabilities of 7T MRI for laminar fMRI in the hippocampus. It demonstrates the optimization of VASO to reduce venous bias and improve signal quality. The findings support the use of advanced acquisition methods to investigate memory retrieval mechanisms at a submillimeter resolution.

7T MRI, fMRI, VASO, hippocampus

Publication

Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter

Published on 2026-04-02 by @MIT

Abstract: AbstractThe retina is an optically accessible part of the central nervous system. Using high-resolution optical coherence tomography, we explored the relationship between retinal thickness and structural features of the brain obtained with magnetic resonance imaging. We hypothesized that there are associations between circumpapillary (i.e., around optic disc) retinal nerve fibre layer thickness and structural features of (i) brain areas and pathways related to visual information processing and ([...]


Our summary: Circumpapillary retinal nerve fibre layer thickness is associated with visual cortex grey matter density and optic radiation fractional anisotropy. Cardiovascular risk factors impact brain structure, but their correlation with retinal thickness was not significant. Further studies are needed to explore the relationship between eye and brain health in the context of neurodegenerative diseases.

retinal nerve fibre layer, brain structure, optical coherence tomography, cardiovascular risk factors

Publication

Sujets abordés : Science de la longévité, durée de vie en bonne santé, durée de vie, mécanismes biologiques, sénescence cellulaire, dynamique des télomères, altérations épigénétiques, fonction mitochondriale, inflammation systémique, biologie moléculaire, génétique, pharmacologie, bioinformatique, composés sénolytiques, mimétiques de la restriction calorique, thérapies par cellules souches, reprogrammation épigénétique, biomarqueurs du vieillissement, agents géroprotecteurs ISO 22118, ISO 22120, ISO 22000, ISO 9001 et ISO 14001.

Contexte historique

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2013-09-24
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2013

(si la date est inconnue ou non pertinente, par exemple « mécanique des fluides », une estimation arrondie de son émergence notable est fournie)

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