再生医学致力于通过整合干细胞生物学、组织工程和生物材料科学来修复或替代受损的组织和器官。这一跨学科领域运用支架构建、细胞重编程和基因编辑等技术来促进组织再生、增强伤口愈合并开发功能性器官替代物。研究方向包括细胞分化、免疫调节、血管生成和细胞外基质重塑，以优化治疗效果。本页面汇总了最新的同行评审研究和专利成果。 技术 推进再生策略、生物材料创新和临床应用，重新定义组织修复和器官替代的方法。
这是我们最新精选的关于再生医学的全球出版物和专利，这些出版物和专利在众多科学在线期刊中进行了分类，主要涉及干细胞、组织工程、细胞疗法、生物材料、支架制造、诱导多能干细胞、再生支架、细胞外基质、器官再生、3D 生物打印、生长因子、间充质干细胞、细胞分化、基因编辑、伤口愈合、再生生物材料、细胞移植、免疫调节、组织再生、细胞重编程、生物活性分子、血管化、再生疗法、自体细胞、异体细胞、再生植入物、细胞扩增、基质重塑和再生微环境。.
Pharmaceutical composition for treating or preventing bone diseases comprising platelets
Patent published on the 2026-07-02 in WO under Ref WO2026142341 by DEWCELL INC [KR] (Shin Eung Kyun [kr], Kim Jung Hee [kr], Kim Chi Hwa [kr], Jeon Hyo Jin [kr])
Abstract: The present invention relates to a pharmaceutical composition for treating or preventing bone diseases, comprising platelets and, more specifically, to a pharmaceutical composition for treating or preventing bone diseases, comprising artificial platelets having an increased concentration of any one growth factor selected from the group consisting of PDGF-AA, PDGF-BB, EGF, TGF-β, bFGF, and VEGF, thereby promoting the synthesis of chondrocytes, inhibiting inflammatory responses, and reducing the [...]
Our summary: The invention involves a pharmaceutical composition for bone disease treatment using platelets. It includes artificial platelets with enhanced growth factor concentrations. This composition promotes chondrocyte synthesis and reduces inflammation and matrix degradation.
pharmaceutical composition, bone diseases, platelets, growth factors
Patent
Gpc3-targeted molecules and uses thereof
Patent published on the 2026-07-02 in WO under Ref WO2026143003 by ATARA BIOTHERAPEUTICS INC [US] (Harris Joel [us], Chen Xianhui [us], Yang Shuai [us])
Abstract: Various embodiments of the invention provide binding agents for glypican-3 (GPC3), including antibodies or antigen-binding fragments thereof that bind to GPC3 and antigen recognizing receptors (e.g., CARs) that target GPC3 including cells that express GPC3. Embodiments of the i n vention also provide cells comprising such binding agents such as CAR T-cells, therapeutic compositions comprising such cells and methods of using one or more of the binding agents, cells or therapeutic compositions for[...]
Our summary: The invention provides GPC3-targeted binding agents, including antibodies and CAR T-cells, for treating diseases like hepatocellular carcinoma. It includes therapeutic compositions and methods utilizing these agents for effective treatment. Additionally, it describes systems combining radiofrequency ablation with GPC3-targeted therapies and immune modulators to enhance treatment efficacy.
GPC3, CAR T-cells, antibodies, hepatocellular carcinoma
Patent
Use of a mechanical force in the implementation of a process of preparation of immunomodulatory drugs
Patent published on the 2026-07-01 in EP under Ref EP4768476 by UNIV MONTPELLIER [FR] (Solorzano-rodriguez Ruben [fr], Colacino Evelina [fr], Chatzigiannis Christos [fr], Bordier Corentin [fr])
Abstract: The invention relates to the use of a mechanical force to generate a mechanochemical reaction in the implementation of a process of preparation of immunomodulatory drugs of Formula (I) or a pharmaceutically acceptable salt thereof, and their process of preparation.[...]
Our summary: The invention utilizes mechanical force to induce a mechanochemical reaction. This process is aimed at preparing immunomodulatory drugs of Formula (I) or their pharmaceutically acceptable salts. The focus is on the innovative application of mechanical energy in drug preparation.
mechanical force, mechanochemical reaction, immunomodulatory drugs, pharmaceutical preparation
Patent
Microspheres comprising decellularized extracellular matrix, natural biopolymer and crosslinking agent and methods for making and using the same
Patent published on the 2026-07-01 in EP under Ref EP4768050 by FUNDACION TECNALIA RES & INNOVATION [ES] (Olalde Beatriz [es], Garcia Lizarribar Andrea Alicia [es])
Abstract: The present disclosure relates generally to microspheres comprising decellularized tissue extracellular matrix, at least a natural biopolymer, and at least a crosslinking agent. In some embodiments, the microsphere comprises biological cells and/or at least a biomolecule. Moreover, the present disclosure also relates to the method of generating said microspheres and the uses thereof.[...]
Our summary: The disclosure details microspheres made from decellularized extracellular matrix, natural biopolymers, and crosslinking agents. It includes methods for creating these microspheres and their potential applications. Some embodiments feature biological cells and biomolecules within the microspheres.
Microspheres, Decellularized ECM, Biopolymer, Crosslinking Agent
Patent
Use of n-terminal fragment of igfbp-4 in clinical assessment of heart failure and coronary heart disease
Patent published on the 2026-07-01 in EP under Ref EP4768919 by SHENZHEN MINDRAY BIOMEDICAL ELECTRONICS CO LTD [CN] (Liu Junjun [cn], Zhang Yi [cn], Wang Jing [cn], Li Ke [cn])
Abstract: The present disclosure relates to the technical field of biomedicine, in particular the use of an N-terminal fragment of insulin-like growth factor binding protein-4 in the clinical assessment of heart failure and coronary heart disease.[...]
Our summary: The N-terminal fragment of IGFBP-4 is utilized in the clinical assessment of heart failure and coronary heart disease. This fragment serves as a biomarker for evaluating these conditions. The research emphasizes its significance in biomedicine.
IGFBP-4, heart failure, coronary heart disease, biomarker
Patent
Improvement of artificial hair follicle germ
Patent published on the 2026-06-25 in WO under Ref WO2026134189 by ORGANTECH INC [JP] (Toyoshima Koh-ei [jp], Ogawa Miho [jp], Tsuji Takashi [jp])
Abstract: An artificial hair follicle germ 10 has a three-dimensional structure in which a first block 11 including hair follicle epithelial stem cells, a second block 12 including hair papilla cells, and a third block 13 including dermal-derived mesenchymal cells (DDMCs) are stacked in this order. A method for artificially preparing a hair follicle germ 10 includes three-dimensionally culturing a first block 11 including hair follicle epithelial stem cells, a second block 12 including hair papilla cells,[...]
Our summary: The artificial hair follicle germ consists of stacked blocks of epithelial stem cells, hair papilla cells, and dermal-derived mesenchymal cells. A method for its preparation involves three-dimensional culturing these components in a specific order. This innovation aims to improve hair follicle regeneration.
artificial hair follicle, three-dimensional culture, epithelial stem cells, dermal-derived mesenchymal cells
Patent
Kovacs-like memory effect in strain stiffening collagen networks
Published on 2026-06-10 by Abhishek Ghadai, Maitri Mandal and Sayantan Majumdar @IOP SCIENCE
Abstract: Materials driven far from equilibrium can encode memories of past deformations through long-lived structural reorganizations. Such memory effects-reflecting parameters such as deformation direction, magnitude, and duration have been widely explored in soft amorphous solids. Here, we report a Kovacs-like memory effect manifested as a non-monotonic stress relaxation in vitro biopolymer networks formed by type-I collagen, an essential component of the mammalian extracellular matrix. Using shear rhe[...]
Our summary: The study identifies a Kovacs-like memory effect in type-I collagen networks. This effect is linked to non-monotonic stress relaxation during nonlinear strain-stiffening. The findings reveal a correlation between memory response and negative normal stresses in biopolymer networks.
memory effect, strain stiffening, collagen networks, viscoelasticity
Publication
Joint material and shape optimization of a 3D printing nozzle by CFD and response surface methodology
Published on 2026-03-12 by @OXFORD
Abstract: AbstractThree-dimensional printing (3D printing) has emerged as a transformative technology in medicine, enabling the fabrication of complex structures with high precision. In bioprinting, optimization of nozzle design is essential to balance print resolution, mechanical strength, and biocompatibility. This study presents a computational framework for optimizing bioprinting performance by simultaneously accounting for nozzle geometry and biomaterial rheological properties. Using computational fl[...]
Our summary: This study presents a computational framework for optimizing bioprinting by integrating nozzle geometry and biomaterial properties. It utilizes CFD and response surface methodology to identify optimal nozzle configurations. Results show significant improvements in flow rate and reductions in wall shear stress, demonstrating the effectiveness of the approach.
3D printing, nozzle optimization, computational fluid dynamics, response surface methodology
Publication
