再生医学致力于通过整合干细胞生物学、组织工程和生物材料科学来修复或替代受损的组织和器官。这一跨学科领域运用支架构建、细胞重编程和基因编辑等技术来促进组织再生、增强伤口愈合并开发功能性器官替代物。研究方向包括细胞分化、免疫调节、血管生成和细胞外基质重塑，以优化治疗效果。本页面汇总了最新的同行评审研究和专利成果。 技术 推进再生策略、生物材料创新和临床应用，重新定义组织修复和器官替代的方法。
这是我们最新精选的关于再生医学的全球出版物和专利，这些出版物和专利在众多科学在线期刊中进行了分类，主要涉及干细胞、组织工程、细胞疗法、生物材料、支架制造、诱导多能干细胞、再生支架、细胞外基质、器官再生、3D 生物打印、生长因子、间充质干细胞、细胞分化、基因编辑、伤口愈合、再生生物材料、细胞移植、免疫调节、组织再生、细胞重编程、生物活性分子、血管化、再生疗法、自体细胞、异体细胞、再生植入物、细胞扩增、基质重塑和再生微环境。.
One-pot method for recombinant geranylgeranylated protein production
Patent published on the 2026-06-11 in WO under Ref WO2026122736 by MOZHDEHI DAVOUD [US] (Alam Md Mahbubul [us], Mozhdehi Davoud [us])
Abstract: A method for the one-pot production of geranylgeranylated proteins in Escherichia coli. E. coli is engineered to express geranylgeranyl pyrophosphate synthase, an enzyme that catalyzes production of geranylgeranyl pyrophosphate, and a target protein. By co-expressing GGS with a geranylgeranyltransferase, efficient geranylgeranylation of model protein substrates was achieved, including intrinsically disordered elastin-like polypeptides (ELPs) and the globular protein mCherry. This modification af[...]
Our summary: A one-pot method for producing geranylgeranylated proteins in E. coli was developed. The method involves co-expressing geranylgeranyl pyrophosphate synthase and geranylgeranyltransferase for efficient modification of target proteins. This approach is scalable and cost-effective, enhancing studies on lipid-modified proteins for drug delivery and tissue engineering.
recombinant proteins, geranylgeranylation, Escherichia coli, protein engineering
Patent
Pharmaceutical composition and use thereof, and kit
Patent published on the 2026-06-11 in WO under Ref WO2026119201 by GAN & LEE PHARM CO LTD [CN] (Jiao Jiao [cn], Cui Zhengzhi [cn], Ye Rongcai [cn])
Abstract: Provided are a pharmaceutical composition and a use thereof, and a kit, relating to the technical field of gene therapy. The pharmaceutical composition comprises a recombinant adeno-associated virus (rAAV), a surfactant, and a buffer solution. The rAAV comprises a nucleic acid, and the nucleic acid comprises a coding sequence. The coding sequence is a nucleotide sequence encoding an anti-vascular endothelial growth factor (VEGF) fusion protein or an anti-VEGF antibody. The pharmaceutical composi[...]
Our summary: The pharmaceutical composition includes a recombinant adeno-associated virus with a nucleic acid encoding an anti-VEGF fusion protein. It demonstrates stability and safety, ensuring long-term expression of the exogenous gene. This composition is effective for treating patients with ophthalmic diseases.
gene therapy, recombinant adeno-associated virus, anti-VEGF, ophthalmic diseases
Patent
Lineage-loci engineered cell therapy and related methods of producing and using same
Patent published on the 2026-06-11 in WO under Ref WO2026123001 by UMOJA BIOPHARMA INC [US] (O'hara Samantha [us], Romanov Artem [us], Koning Ryan [us], Vereide David T [us], Yingst Ashley M [us], Jarrell Dillon [us])
Abstract: Provided herein are genetically engineered cells containing a payload in a lineage specific locus and related methods and uses thereof in cell therapy. In some embodiments, the cells are genetically engineered with a CAR, such that expression of the CAR is delayed until the cell is differentiated to a lineage. In some embodiments, the genetically modified cells can be selected for using a selection cassette. Also provided are cell compositions containing the engineered cells, and related methods[...]
Our summary: This content discusses lineage-loci engineered cell therapy and methods for producing genetically engineered cells. It highlights the use of CARs that are expressed upon cell differentiation. Additionally, it covers cell compositions, selection methods, and applications in cancer immunotherapy.
cell therapy, genetically engineered cells, CAR, lineage-specific locus
Patent
Method for preparing porcine induced pluripotent stem cell
Patent published on the 2026-06-11 in US under Ref US20260159814 by SIMPLE PLANET CO LTD [KR] (Han Dongoh [kr], Park Hee Ho [kr], Yoo Ki Hyun [kr], Seo Bong Jong [kr], Jeong Ildoo [kr], Lim Jee Yoon [kr], Kim Kwan Hyun [kr])
Abstract: [0000] The present invention relates to a method for preparing porcine induced pluripotent stem cells (piPSCs), wherein hOCT3, hOCT4, hSK, hUL, mP53DD, and EBNA1 genes are introduced into porcine embryonic fibroblasts by electroporation, thereby producing piPSCs without problems caused by the integration of foreign genes. The porcine induced pluripotent stem cells prepared by the preparation method of the present invention have pluripotency and spontaneous differentiation capability, and in part[...]
Our summary: The invention describes a method for preparing porcine induced pluripotent stem cells (piPSCs) using electroporation to introduce specific genes. This method avoids issues related to foreign gene integration. The resulting piPSCs exhibit pluripotency and strong differentiation potential, particularly towards myotube cells, making them suitable for the cultured meat industry.
induced pluripotent stem cells, porcine, electroporation, differentiation
Patent
Kovacs-like memory effect in strain stiffening collagen networks
Published on 2026-06-10 by Abhishek Ghadai, Maitri Mandal and Sayantan Majumdar @IOP SCIENCE
Abstract: Materials driven far from equilibrium can encode memories of past deformations through long-lived structural reorganizations. Such memory effects-reflecting parameters such as deformation direction, magnitude, and duration have been widely explored in soft amorphous solids. Here, we report a Kovacs-like memory effect manifested as a non-monotonic stress relaxation in vitro biopolymer networks formed by type-I collagen, an essential component of the mammalian extracellular matrix. Using shear rhe[...]
Our summary: The study identifies a Kovacs-like memory effect in type-I collagen networks. This effect is linked to non-monotonic stress relaxation during nonlinear strain-stiffening. The findings reveal a correlation between memory response and negative normal stresses in biopolymer networks.
memory effect, strain stiffening, collagen networks, viscoelasticity
Publication
Computerized method of making a patient-specific orthopedic reconstruction
Patent published on the 2026-06-04 in US under Ref US20260151234 by BLUE SKY TECH LLC [US] (Castro Frank [us])
Abstract: A computerized system and method (123A-C) for the automated design and additive manufacturing of patient-specific orthopedic reconstructions (600R). The method integrates anatomically tagged medical scans, oriented relative to X, Y, and Z axes, with machine-learning models trained on aggregate historical biomechanical outcomes to generate optimized implant geometries. The system calculates an Osseointegration Probability Score (OPS) and a Comprehensive Prognostic Success Score (CPSS) to dynamica[...]
Our summary: The method automates the design and manufacturing of patient-specific orthopedic implants using medical scans and machine-learning models. It calculates scores to optimize implant geometry and internal structures for better stability and reduced complications. The system integrates biomechanical simulations with clinical data for enhanced long-term outcomes.
Orthopedic reconstruction, Additive manufacturing, Machine learning, Biomechanical simulation
Patent
Microcurrent application apparatus for wound healing
Patent published on the 2026-06-04 in US under Ref US20260151619 by BIOLAMP CO LTD [KR] (Seo Minsik [kr], Kim Soyang [kr], Seo Hyukjin [kr], Lee Youngsoon [kr])
Abstract: [0000] Proposed is a microcurrent application apparatus for wound healing. The microcurrent application apparatus includes a healing pad part attached to a wound site, a pH sensor attached to the healing pad part and configured to measure a pH value of the wound site, at least one electrode attached to the healing pad part and configured to apply a microcurrent to the wound site, and a current controller configured to control at least one of polarity and intensity of the microcurrent applied thr[...]
Our summary: The apparatus applies microcurrent to wounds for healing. It includes a pH sensor to measure wound acidity. The current is adjusted based on pH to enhance therapeutic outcomes.
Microcurrent, wound healing, pH sensor, therapeutic effect
Patent
Joint material and shape optimization of a 3D printing nozzle by CFD and response surface methodology
Published on 2026-03-12 by @OXFORD
Abstract: AbstractThree-dimensional printing (3D printing) has emerged as a transformative technology in medicine, enabling the fabrication of complex structures with high precision. In bioprinting, optimization of nozzle design is essential to balance print resolution, mechanical strength, and biocompatibility. This study presents a computational framework for optimizing bioprinting performance by simultaneously accounting for nozzle geometry and biomaterial rheological properties. Using computational fl[...]
Our summary: This study presents a computational framework for optimizing bioprinting by integrating nozzle geometry and biomaterial properties. It utilizes CFD and response surface methodology to identify optimal nozzle configurations. Results show significant improvements in flow rate and reductions in wall shear stress, demonstrating the effectiveness of the approach.
3D printing, nozzle optimization, computational fluid dynamics, response surface methodology
Publication
