生物打印整合了增材制造技术 制造业 利用细胞生物学技术构建三维功能性活体组织和器官结构。该领域涉及精确沉积载有细胞的生物墨水、生物材料和生长因子，以复制天然组织结构和微环境。支架设计、血管化策略和多材料打印技术的进步推动了其在再生医学、药物测试和个性化治疗等领域的应用。以下汇编了最新的同行评审出版物和专利创新，反映了前沿方法、新型生物墨水配方和打印技术。 技术以及正在塑造组织工程和器官制造未来的转化性突破。
这是我们最新精选的有关生物打印的全球出版物和专利，涉及许多科学在线期刊，分类并侧重于生物打印、3D 生物打印、组织工程、生物材料、细胞生物墨水、支架制造、器官打印、水凝胶生物墨水、挤压生物打印、激光辅助生物打印、微阀生物打印、干细胞生物打印、生物墨水配方、生物打印、生物打印分辨率、生物打印软件、生物反应器、生物打印、软骨生物打印和皮肤生物打印。.
Fixed bed bioreactor with reduced bypass and related methods
Patent published on the 2026-05-28 in WO under Ref WO2026111780 by CORNING INCORPORATED [US] (Brawn Tristan Yale [us], Goral Vasiliy Nikolaevich [us], Harding Charles Philip [us], Hong Yulong [us], Meyer Steven Eric [us], Sabin Douglas Grosvenor [us], Timmons Christopher Lee [us])
Abstract: A bioreactor system is provided that includes a cell culture vessel having an interior reservoir defined by an interior wall. A fixed-bed cell culture matrix having a plurality of layers of substrate is contained within the interior reservoir and has a bed height and a bed width in a direction perpendicular to the direction of the bed height. The system further includes a compression sleeve surrounding at least a portion of the fixed-bed cell culture matrix. The compression sleeve exerts a compr[...]
Our summary: A bioreactor system features a fixed-bed cell culture matrix within an interior reservoir. It includes a compression sleeve that applies a compressive force to reduce the bed width. The sleeve can also release the force, allowing the bed width to expand.
bioreactor, cell culture, fixed-bed, compression sleeve
Patent
Microcavity bioreactors and systems for 3d cell culture
Patent published on the 2026-05-28 in WO under Ref WO2026111867 by CORNING INCORPORATED [US] (Fang Ye [us])
Abstract: A microcavity bioreactor is provided that allows cell growth and cell differentiation in the same vessel, such that higher order three-dimensional cell cultures such as organoids can be generated in a singular vessel. The microcavity bioreactor may be part of a microcavity bioreactor system that allows for perfusion based cell culture and perfusion based cell harvesting. The microcavity bioreactor includes at least one, and preferably at least two, fluid distributor structures in the housing ves[...]
Our summary: Microcavity bioreactors enable simultaneous cell growth and differentiation in a single vessel. They facilitate the generation of higher-order 3D cell cultures like organoids. The system incorporates fluid distributor structures for enhanced perfusion-based culture and harvesting.
microcavity bioreactor, 3D cell culture, organoids, perfusion
Patent
Method of synthesis of testosteronan polymer and derivatives and uses thereof
Patent published on the 2026-05-28 in WO under Ref WO2026112535 by WEKA BIOSCIENCES LLC [US] (Otto Nigel J [us])
Abstract: Embodiments of the present invention provides recombinant systems, methods, and compositions for the biological production of Testosteronan (Testan), a linear α-(1→4)-linked glucuronic acid–N-acetylglucosamine polysaccharide. Microbial hosts engineered to express full-length CtTS, N-terminal truncation variants (including d64-CtTS), or the Pseudomonas CIPTS homolog synthesize high–molecular-weight Testan (≥800 kDa) with low polydispersity. Structural analysis by ¹H NMR and 2D HSQC demo[...]
Our summary: The invention details a method for synthesizing Testosteronan (Testan) using engineered microbial hosts. It includes purification techniques to obtain defined molecular-weight fractions and sulfated derivatives. Additionally, it outlines applications for Testan in chromatographic stationary phases and biomaterial scaffolds.
Testosteronan, microbial synthesis, polysaccharide derivatives, chromatographic applications
Patent
Fermentation process for producing polyhydroxyalkanoate
Patent published on the 2026-05-20 in EP under Ref EP4745243 by NG NORDIC FINLAND OY [FI] (Huusela Martina [fi], Pawar Sudhanshu [se])
Abstract: According to an example aspect of the present invention, there is provided a continuous fermentation process for producing at least one polyhydroxyalkanoate. The process comprises the steps of: producing a fermentation broth comprising a biomass in at least one primary bioreactor, and passing the fermentation broth through secondary bioreactors for producing at least one polyhydroxyalkanoate. In the process the biomass comprises at least one micro-organism capable of producing the at least one p[...]
Our summary: The process involves a continuous fermentation method to produce polyhydroxyalkanoate. It utilizes a biomass in primary bioreactors and passes the broth through secondary bioreactors. The pH is maintained between 6 and 8 by adding carbon and nitrogen sources in specific molar ratios.
Fermentation, Polyhydroxyalkanoate, Bioreactor, Micro-organism
Patent
Fully flooded vertical loop bioreactor system, bioreactor and continuous method for aerobic gas-substrate fermentation
Patent published on the 2026-05-20 in EP under Ref EP4745222 by AERBIO AS [DK] (Mansfield Robert [dk], Mulligan Katie [dk], Creer Peter [dk])
Abstract: The present invention relates to the field of aerobic gas-substrate fermentation, in particular for Cupriavidus through a fully flooded vertical loop reactor system.The present invention further relates to a fully flooded vertical loop bioreactor for aerobic gas-substrate fermentation.The present invention further relates to a method for aerobic gas-substrate fermentation using the fully flooded vertical loop bioreactor of the invention.[...]
Our summary: The invention describes a fully flooded vertical loop bioreactor system for aerobic gas-substrate fermentation. It focuses on the fermentation process utilizing Cupriavidus. Additionally, it outlines a continuous method for efficient fermentation in this bioreactor setup.
bioreactor, aerobic fermentation, Cupriavidus, continuous method
Patent
Bioreactor and process to produce osteoarticular organoids
Patent published on the 2026-05-20 in EP under Ref EP4745223 by LYON ECOLE CENTRALE [FR] (Hoc Thierry [fr], Bensidhoum Morad [fr], Potier Esther [fr], Rouquier LÉa [fr], Petite HervÉ [fr])
Abstract: [0001] Invention concerns a method for producing osteoarticular organoids with a bioreactor, the method comprising a mechanical stimulation step that occurs during a feeding step. While the feeding step feeds the cells (CLS) with a nutrient fluid (FLD), the stimulation step provide cyclic compressions to the cells (CLS), in order to activate the mechanical characteristics sought for such osteoarticular organoids depending on its own stiffness. The production occurs in a sterile environment and w[...]
Our summary: The invention describes a method for producing osteoarticular organoids using a bioreactor. It includes a mechanical stimulation step during cell feeding to enhance organoid stiffness. The process is conducted in a sterile, hypoxic environment with regulated temperature for over a month.
Bioreactor, osteoarticular organoids, mechanical stimulation, hypoxic conditions
Patent
Joint material and shape optimization of a 3D printing nozzle by CFD and response surface methodology
Published on 2026-03-12 by @OXFORD
Abstract: AbstractThree-dimensional printing (3D printing) has emerged as a transformative technology in medicine, enabling the fabrication of complex structures with high precision. In bioprinting, optimization of nozzle design is essential to balance print resolution, mechanical strength, and biocompatibility. This study presents a computational framework for optimizing bioprinting performance by simultaneously accounting for nozzle geometry and biomaterial rheological properties. Using computational fl[...]
Our summary: This study presents a computational framework for optimizing bioprinting by integrating nozzle geometry and biomaterial properties. It utilizes CFD and response surface methodology to identify optimal nozzle configurations. Results show significant improvements in flow rate and reductions in wall shear stress, demonstrating the effectiveness of the approach.
3D printing, nozzle optimization, computational fluid dynamics, response surface methodology
Publication
A Case Study in Sabanalarga, Colombia
Published on 2026-02-04 by Lina Henriquez Sarmiento, Hugo Hernndez, Anderson Nieto Granados, Jorge Rodas, Andrea Liliana Moreno-Ros, Andreas Hasse, Diana Pinto, Claudete Gindri Ramos @MDPI
Abstract: Technosols are artificial soils produced from organic and inorganic solid waste to improve soil fertility and functionality. This study evaluated the potential of Technosols produced from household waste from the Altos de Guadalupe residential complex in Colombia to fertilize green areas and promote the growth of Duranta erecta. A physical characterization of waste from 46 houses was performed to estimate per capita production (PPC) and waste composition. Technosols were produced in 20, 50, and [...]
Our summary: Technosols made from household waste were evaluated for their ability to enhance soil fertility and promote plant growth in Sabanalarga, Colombia. The study found that Technosols significantly improved soil organic matter and nutrient availability, leading to increased plant height and root dry matter. These findings support the use of Technosols in urban agriculture, aligning with circular economy principles and sustainable development goals.
Technosols, soil fertility, organic waste, urban agriculture
Publication
