This is our latest selection of worldwide publications and patents in english on Microfluidics, between many scientific online journals, classified and focused on microfluidics, microchannel, lab-on-a-chip, capillary action, electrowetting, surface tension, microfabrication and microreactor.
The Role of Computational Fluid Dynamics and Experimental Investigation
Published on 2025-03-09 by Behrouz Pirouz, Hana Javadi Nejad, Anna Selene Chirillo, Seyed Navid Naghib, Patrizia Piro @MDPI
Abstract: The growing use of microfluidic-based devices necessitates an analysis of flow characteristics through both experimental methods and computational fluid dynamic (CFD) simulations. CFD simulations facilitate the investigation of various devices, including medical sensors, by providing detailed insights into flow behavior. In this study, we conducted experimental and CFD analysis of the microfluidic flow in three devices: a COVID-19 rapid test kit, a blood glucose kit, and a PDMS kit. Our findings[...]
Our summary: The study explores the flow characteristics of microfluidic devices through experimental methods and CFD simulations, revealing the impact of wall adhesion on flow speed predictions. Hemodynamic analysis of blood glucose and PDMS kits highlights the importance of microchannel diameter on flow speed. CFD results emphasize the role of porosity, surface tension coefficients, and contact angles in optimizing sensor development.
Computational Fluid Dynamics, Experimental Investigation, Microfluidic Devices, CFD simulations
Publication
Thermophysical and Tribological Properties
Published on 2025-03-08 by Jos� M. Li�eira del R�o, Alonso Alba, Mart�n G�mez Mart�nez, Alfredo Amigo, Josefa Fern�ndez @MDPI
Abstract: The aim of this research is to analyze the thermophysical, wettability, and tribological properties of some base oils of different nature (synthetic and mineral), as well as of formulated oils, to find potential transmission oils for electrical vehicles. Regarding the thermophysical properties, viscosity, density, and viscosity index were analyzed. Surface tension and contact angle were also measured to obtain the wettability performance of tested lubricants. The highest viscosities were found f[...]
Our summary: The research analyzes thermophysical, wettability, and tribological properties of base oils for potential transmission oils for electric vehicles. Viscosity, density, and viscosity index were studied, along with surface tension and contact angle for wettability performance. The lowest coefficients of friction and wear were found in formulated lubricants with additive packages.
thermophysical, tribological, wettability, viscosity
Publication
The Influence of Sample Microfabrication and Annealing on the Mechanical Strain–Stress Behavior of Stainless Steels and Corrosion Resistant Aluminum Alloys in Micro-Tensile Tests
Published on 2025-03-06 by Janko Auerswald, Joel Tenisch, Christoph Fallegger, Markus Seifert @MDPI
Abstract: Miniaturized components for enhanced integrated functionality or thin sheets for lightweight applications often consist of face-centered cubic metals. They exhibit good strength, corrosion resistance, formability and recyclability. Microfabrication technologies, however, may introduce cold work or detrimental heat-induced lattice defects into the material, with consequences for the mechanical properties. Austenitic stainless steels (1.4310, 1.4301) and aluminum alloys (EN AW-5005-H24, EN AW-6082[...]
Our summary: The study investigates the impact of sample microfabrication and annealing on the mechanical behavior of stainless steels and aluminum alloys in micro-tensile tests, revealing the formation of shear band zones in certain materials and the influence of cutting methods on deformation.
Microfabrication, Annealing, Mechanical Strain-Stress Behavior, Micro-Tensile Tests
Publication
Burst Ultrafast Laser Welding of Quartz Glass
Published on 2025-03-06 by Xianshi Jia, Yinzhi Fu, Kai Li, Chengaonan Wang, Zhou Li, Cong Wang, Ji�an Duan @MDPI
Abstract: Ultrafast laser welding of transparent materials has been widely used in sensors, microfluidics, optics, etc. However, the existing ultrafast laser welding depths are limited by the short laser Rayleigh length, which makes it difficult to realize the joining of transparent materials in the millimeter depth range and becomes a new challenge. Based on temporal shaping, we realized Burst mode ultrafast laser output with different sub-pulse numbers and explored the effect of different Burst modes on[...]
Our summary: Burst mode ultrafast laser welding of quartz glass with depths up to 5 mm is achieved through temporal shaping. The welding strength can exceed 18.18 MPa, providing a new method for joining large-size transparent materials.
Ultrafast Laser Welding, Burst Mode, Quartz Glass, Temporal Shaping
Publication
Isolation and expansion of natural killer cells using fluorescence-activated droplet sorting
Patent published on the 2025-03-06 in WO under Ref WO2025050133 by NORTHEASTERN UNIV [US] (Konry Tania [us], Estevam Jose [us], White Rachel [us])
Abstract: A high-throughput microfluidics-based fluorescence activated droplet sorting (FADS) system provides activation, sorting, and feeder cell-free expansion of NK cells that are enriched for killing activity. The NK cells are activated and identified based on their ability to kill target cells, such as tumor cells, without prior sensitization. The diversity of endogenous NK cells can be overcome to allow selection of a highly effective population of cells for therapeutic use, such as in the treatment[...]
Our summary: High-throughput FADS system for isolation and expansion of NK cells with killing activity, selection of effective NK cell population for cancer treatment, activation and identification of NK cells based on killing ability.
microfluidics, fluorescence-activated droplet sorting, natural killer cells, expansion
Patent
Light valve system with gap maintenance system
Patent published on the 2025-03-06 in WO under Ref WO2025049744 by SEURAT TECH INC [US] (Elhadj Selim [us], Sargolzaeiaval Yasaman [us], Davidson Zoey [us])
Abstract: A light valve can include a liquid crystal layer having a first and a second side. A first substrate is positioned in contact with the first side of the liquid crystal layer, with the first substrate having a first semiconductor layer. A second substrate is positioned in contact with the second side of the liquid crystal layer, with the second substrate having a second semiconductor transparent electrode layer and a second semiconductor layer. A plurality of laser transparent aperture support st[...]
Our summary: Light valve system with gap maintenance system, includes liquid crystal layer with first and second sides, substrates with semiconductor layers, and laser transparent aperture support structures for stable uniform gap.
light valve system, gap maintenance system, liquid crystal layer, semiconductor layer
Patent
Multiplexed diagnostic assay device
Patent published on the 2025-03-06 in WO under Ref WO2025049225 by ACCESS BIO INC [US] (Choi Young Ho [us], Back Jungho [us], Kim Hyoungsoo [us], Jang Myungkyu [us], Kim Hyeon Suk [us], Lee Ji Yun [us])
Abstract: Diagnostic assay devices for detecting the presence of an analyte in a sample solution may comprise a microreactor configured to form a sample solution containing the analyte, flow the sample solution therethrough in a first direction to form an analyte-capture molecule complex, and transfer the sample solution to an absorbent strip pad configured to flow therethrough, in a second direction crossing the first direction, the sample solution including the analyte-capture molecule complex and indic[...]
Our summary: Microreactor for sample solution, analyte-capture molecule complex formation, absorbent strip pad for detection, bioaerosol sample processing, multiplexed detection of multiple analytes including SARS-Cov2, RSV, influenza A and B.
multiplexed, diagnostic, assay, device
Patent
High-throughput condensate modulator screen
Patent published on the 2025-03-06 in WO under Ref WO2025050003 by TRANSITION BIO INC [US] (Knowles Tuomas Pertti Jonathan [gb], Arora Shilpi [us], Arter William Emrys [gb], Seeber Andrew Ciaran [us], Saar Kadi Liis [ee], Rebmann Marius [gb])
Abstract: The present invention is an ultra-high throughput droplet microfluidics platform that is possible to search through small-molecule chemical space to discover molecules directly through their signatures on protein phase behavior changes. Furthermore, the molecules discovered through this approach are modulators of phase transition characteristics of condensates or of LLPS of target macromolecules. These modulators induce desired functional and/or phenotypical changes, e.g., in cells and living sy[...]
Our summary: Ultra-high throughput droplet microfluidics platform for discovering molecules through protein phase behavior changes, modulators of condensate phase transition characteristics, inducing functional changes in cells, screening phase diagrams for FUS phase separation stabilizers and destabilizers, new approach to drugging biomolecular condensate-dependent pathways.
High-throughput, condensate modulator, droplet microfluidics, phase transition
Patent
FR 
EN 
DE 
ES 
IT