Dies ist unsere neueste Auswahl an weltweiten Veröffentlichungen und Patente in englischer Sprache auf Natriumpolyacrylat and super-absorbant polymers, between many scientific online journals, classified and focused on sodium polyacrylate, superabsorbent, super-absorbent, water-absorbing, polyacrylate, hydrogel, waterlock and diapers.
Therapeutic Potential of Cannabidiol Cyclodextrin Complex in Polymeric Micelle and Tetrahydrocurcumin Cyclodextrin Complex Loaded in Hydrogel to Treat Lymphedema
Published on 2025-04-06 by Waritorn Srakhao, Titpawan Nakpheng, Mohd Cairul Iqbal Mohd Amin, Teerapol Srichana @MDPI
Abstract: Cannabidiol (CBD) and tetrahydrocurcumin (THC) have demonstrated anti-inflammatory activity as well as generating new lymph vessels. We present the formulations and evaluations of CBD and THC loaded in hydrogels for the treatment of lymphedema to promote angiogenesis of lymph vessels and an anti-inflammatory response. Six CBD-THC hydrogel formulations were prepared and evaluated. The hydrodynamic particle sizes were 302.0–545.1 nm and the zeta potentials were from −58[...]
Our summary: Therapeutic potential of CBD and THC loaded in hydrogels for lymphedema treatment, Formulations and evaluations of CBD-THC hydrogel, Induction of angiogenesis and anti-inflammatory response in lymphatic vessels
Cannabidiol, Cyclodextrin, Polymeric Micelle, Tetrahydrocurcumin
Application of Polysaccharides in Hydrogel Biomaterials
Published on 2025-04-04 by Piotr Szatkowski, Zuzanna Flis, Anna Ptak, Edyta Molik @MDPI
Abstract: Natural compounds incorporated into hydrogel materials have been widely used to support wound healing due to their numerous properties. The aim of this research was to produce hydrogel biomaterials with the addition of adjuvants, such as sodium alginate and polyethylene glycol diacrylate (PEGDA) with the addition of ethylene ginger extract (EEI). A thermogravimetric (TG) study, differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), water absorption testing and microscopic an[...]
Our summary: Research on hydrogel biomaterials with natural compounds and adjuvants to support wound healing. Evaluation of properties through various analytical techniques. 4%Alg/12%PEGDA hydrogel showed best water absorption and stress dissipation. 4%Alg/12%PEGDA/12%EEI hydrogel exhibited highest hydrophilic properties and ionic conductivity. Addition of PEGDA and EEI increased acidity, potentially beneficial for wound management.
Polysaccharides, Hydrogel Biomaterials, Sodium Alginate, Polyethylene Glycol Diacrylate
Publication
Tracking the Effect of Phosvitin (PV) Concentration on the Skin Permeation of Somatotropin (STH) from Semi-Solid Hydrogel Formulations
Published on 2025-04-04 by Wioletta Siemiradzka @MDPI
Abstract: Recombinant human growth hormone (rhGH) is utilized in pediatric patients with short stature for a variety of indications, including those in which the primary growth defect is not related to growth hormone deficiency (GHD). However, due to the instability of the hormone in the gastrointestinal tract and its short half-life, an alternative route of administration is being sought, which may be the skin. One strategy to extend the half-life of proteins involves the use of biodegradable polymeric m[...]
Our summary: Study optimizing PV concentration for enhancing STH permeation through skin using hydrogel formulations. Evaluation of physicochemical parameters for formulation stability and persistence.
Phosvitin, Skin Permeation, Somatotropin, Hydrogel
Publication
Adaptability Evaluation of High-Density Kill Fluid for Ultra-Deep and Ultra-High Temperature Well Testing in Tarim Oilfield
Published on 2025-04-02 by Junyan Liu, Lili Li, Shuang Liu, Yan Ye, Sihan Cheng, Kun Wang, Lang Wang, Zhenjiang Wu, Jun Wu @MDPI
Abstract: To address the insufficient long-term stability of kill fluids in ultra-deep, ultra-high-temperature wells in the Tarim Oilfield, this study systematically evaluates the adaptability of high-density kill fluids under high-temperature and prolonged static aging conditions, with a focus on identifying dominant settling mechanisms. The correlation between the microstructure and macroscopic properties of kill fluids was elucidated through particle size distribution analysis, scanning electron micros[...]
Our summary: To evaluate high-density kill fluids for ultra-deep, ultra-high-temperature well testing in Tarim Oilfield, this study assesses their adaptability under extreme conditions. Through various analyses, settling mechanisms are identified, and a grading criterion for settling stability is established. Key findings show that low-density kill fluids maintain stability, while high-density systems experience severe particle aggregation, providing valuable insights for optimizing formulations and ensuring safe operations in ultra-high-temperature wells.
Adaptability, High-Density, Kill Fluid, Evaluation
Publication
Engineering Adhesive Hydrogels for Hemostasis and Vascular Repair
Published on 2025-04-01 by Juya Jeon, Shri Venkatesh Subramani, Kok Zhi Lee, Santiago Elizondo-Benedetto, Mohamed Adel Zayed, Fuzhong Zhang @MDPI
Abstract: Adhesive hydrogels with tunable mechanical properties and strong adhesion to wet, dynamic tissues have emerged as promising materials for tissue repair, with potential applications in wound closure, hemorrhage control, and surgical adhesives. This review highlights the key design principles, material classifications, and recent advances in adhesive hydrogels designed for vascular repair. The limitations of existing adhesive hydrogels, including insufficient mechanical durability, suboptimal bioc[...]
Our summary: Review of engineering adhesive hydrogels for hemostasis and vascular repair, Highlighting design principles and recent advances, Discussing limitations and innovative strategies for improvement.
Adhesive hydrogels, Engineering, Vascular repair, Mechanical properties
Publication
High-Quality Preparation of Energy-Containing Microspheres with Cross-Scale Particle Size
Published on 2025-03-31 by Jiang Liu, Hairui Bian, Guoqiang Yu, Jiachao Zhang, Yaozheng Wang, Dang Ding, Ning Sang, Fangsheng Huang @MDPI
Abstract: Microfluidic granulation technology enables high-quality production of energy-containing microspheres, significantly enhancing both performance and safety. Although microfluidic methods allow control over microsphere particle size, the adjustment range remains limited; low yield and process discontinuity also restrict broader application in the synthesis of energy-containing materials. This paper presents a microfluidic granulation system for energy-containing materials utilizing pulsed pneumati[...]
Our summary: High-quality production of energy-containing microspheres with cross-scale particle size using microfluidic granulation technology, enabling wide particle size adjustment and efficient energy material loading.
Microfluidic, Granulation, Energy-containing, Microspheres
Publication
Methods of using nanovials to associate secretions and transcriptomes of single cells
Patent published on the 2025-03-20 in WO under Ref WO2025059192 by THE REGENTS OF THE UNIV OF CALIFORNIA [US] (Di Carlo Dino [us], Plath Kathrin [us], Udani Shreya [us], Langerman Justin [us])
Abstract: A Secretion EnCoded (SEC) single-cell sequencing (seq) (SEC-seq) method and platform is disclosed which exploits hydrogel particles with sub-nanoliter cavities (nanovials) to capture individual cells and their secretions. This enables one to simultaneously measure the secretions and the transcriptome for a population of cells. In one example, the method was used measure secretion of vascular endothelial growth factor A (VEGF-A) and the transcriptome for thousands of individual mesenchymal stroma[...]
Our summary: Method using nanovials to capture single cells and their secretions for simultaneous measurement of secretions and transcriptome. Enables identification of gene-signatures linked to specific secretory states and development of means to modulate cellular secretion. Improved therapeutic compositions of MSCs yielding enhanced secretions of therapeutic molecules also disclosed.
nanovials, single-cell sequencing, SEC-seq, secretory subpopulations
Patent
Fornix insert containing an active agent
Patent published on the 2025-03-20 in WO under Ref WO2025059320 by OCULAR THERAPEUTIX INC [US] (Jarrett Peter [us], El-hayek Rami [us])
Abstract: Disclosed in certain embodiments is a fomix insert comprising a material having a first distal surface and a second distal surface; the first distal surface affixed to a composition comprising a hydrogel and an active agent; the second distal surface comprising a plurality of microneedles extending away from the first distal surface; wherein the fomix insert is configured to be inserted into the fomix with the composition contacting the eyeball and the plurality of microneedles contacting the ey[...]
Our summary: Fornix insert with active agent and hydrogel, featuring microneedles for contact with eyelid and eyeball.
fornix insert, active agent, hydrogel, microneedles
Patent
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