脑机接口是神经组织与外部计算系统之间的直接通信途径，它绕过传统的神经肌肉输出通道，将记录的大脑活动实时转化为设备指令、合成语音或恢复的感觉反馈。
该领域以侵入性为轴心进行划分：非侵入性模式--头皮脑电图、功能性近红外 光谱学 - 在没有手术风险的情况下采集信号，但空间分辨率和信噪比严重受限；放置在皮层表面的皮层电图网格属于中间层；以犹他阵列和 Neuralink 的柔性线电极系统为代表的完全皮层内方法，可同时记录数百到数千个神经元的单个尖峰，但代价是手术植入、异物反应和长期电极稳定性下降。.
信号处理 管道——激增 排序局部场电位分解，以及基于神经群体动力学训练的深度学习解码器，将原始电生理信号转化为高维控制信号，其中运动皮层解码用于光标控制和机器人肢体驱动，语音区解码用于想象或尝试语音合成，代表了临床上最先进的两个应用方向。 闭环 将神经记录与精确计时的皮层或外周神经刺激相结合的架构，正在同时推进中风康复、难治性抑郁症和癫痫治疗。
以下索引中的出版物和专利涵盖电极材料科学、ASIC 前端放大器设计、解码器算法、无线神经遥测、生物兼容性研究，以及 临床试验 在整个侵袭范围内的结果：
这是我们最新精选的全球范围内关于脑机接口（BCI）的英文出版物和专利，涵盖众多科学在线期刊，并按BCI、脑机接口、神经接口、皮层脑电图、皮层内电极阵列、犹他阵列、Neuralink植入物、支架电极BCI、基于脑电图的BCI等主题进行分类和重点介绍。 发动机 皮层解码、神经尖峰排序、局部场电位脑机接口、脉冲神经网络解码器、神经信号放大器、闭环神经刺激、脑机接口运动神经假体、语音脑机接口、想象语音解码、脑机接口光标控制、脑机接口通信设备、神经解码器算法、脑机接口伪迹抑制、柔性神经探针、生物相容性神经电极和脑机接口长期稳定性。
Neuronal avalanches as a predictive biomarker for guiding tailored BCI training programs
Published on 2026-05-29 by @MIT
Abstract: AbstractMotor imagery-based Brain-Computer Interfaces (BCIs) restore control in persons with motor impairments, but up to 30% of users struggle, a phenomenon known as “BCI inefficiency”. This study tackles a key limitation of current protocol: the use of fixed-length sessions training paradigms that ignore individual learning variability. We propose a novel approach based on neuronal avalanches, spatiotemporal cascades of brain activities, as biomarkers to characterize and predict user-speci[...]
Our summary: This study introduces neuronal avalanches as predictive biomarkers for personalized BCI training programs. It analyzes electroencephalography data to correlate avalanche characteristics with BCI performance. The findings support tailored approaches to enhance user success and reduce BCI inefficiency.
neuronal avalanches, BCI training, biomarkers, motor imagery
Publication
Large language models reveal the neural tracking of linguistic context in attended and unattended multi-talker speech
Published on 2026-05-07 by @MIT
Abstract: AbstractLarge language models (LLMs) capture long-range contextual structure in natural language and have recently been shown to align with the human brain’s contextualized linguistic encoding. This makes them a promising computational probe for studying how context-dependent linguistic information is represented during natural speech perception. Speech perception often occurs in multi-talker environments, where attention must dynamically select among competing streams, yet how contextual info[...]
Our summary: Large language models align with human brain encoding of linguistic context. The study explores how attention affects neural tracking of speech in multi-talker environments. Findings indicate that both attended and unattended speech streams contribute to neural predictions based on contextual information.
language models, neural tracking, speech perception, auditory attention
Publication
Suppression of inflammation associated with implants
Patent published on the 2026-05-07 in WO under Ref WO2026092500 by SUNMED THERAPEUTIC LTD [CN] (Sun Joseph [cn], Sun Dongxu [cn])
Abstract: Provided herein are methods and compositions for suppressing a foreign body reaction, such as an implant-associated inflammation in a subject, by using an anti-Galectin-3 antibody. Such methods and compositions can be used in various areas applications where an implant is introduced, such as in brain-computer interface (BCI).[...]
Our summary: Methods and compositions are described for suppressing implant-associated inflammation using an anti-Galectin-3 antibody. These approaches target the foreign body reaction in subjects receiving implants. Applications include areas like brain-computer interfaces (BCI).
anti-Galectin-3, inflammation suppression, foreign body reaction, implants
Patent
Towards the use of functional near-infrared spectroscopy as an assessment tool in disorders of consciousness
Published on 2026-04-30 by @MIT
Abstract: AbstractFunctional near-infrared spectroscopy (fNIRS) has emerged as a promising neuroimaging tool for assessing patients with disorders of consciousness (DoC). While functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have advanced the detection of covert brain function, their use is often constrained by accessibility, medical and physical contraindications, and practical limitations. fNIRS offers a portable, safe, and cost-effective alternative capable of measuring he[...]
Our summary: Functional near-infrared spectroscopy (fNIRS) is a promising tool for assessing disorders of consciousness (DoC). It provides a portable and cost-effective alternative to fMRI and EEG for measuring brain function. Future research should focus on validation, multimodal integration, and ethical access to enhance DoC care.
fNIRS, disorders of consciousness, neuroimaging, brain-computer interfaces
Publication
A reference-less level-crossing adc with a bump-based adaptive-bias comparator
Patent published on the 2026-04-22 in EP under Ref EP4730654 by IMEC VZW [BE] (Yang Xiaolin [be], Xing Xiaonan [be], Sawigun Chutham [be], Mora Lopez Carolina [be])
Abstract: This disclosure relates to a comparator circuit and an ADC circuit for a neural interface. The ADC circuit includes the comparator circuit. The comparator circuit comprises a comparator to receive a first and a second signal, and internally amplify the first and the second signal. A bump bias circuit of the comparator circuit receives the amplified first and second signal, and causes the comparator to operate at a higher power level when a difference between the amplified first and second signal[...]
Our summary: The disclosure describes a reference-less level-crossing ADC featuring a bump-based adaptive-bias comparator. The comparator amplifies two input signals and adjusts its power level based on their difference. The ADC includes two comparator circuits and switching circuits controlled by a control circuit for capacitor state management.
ADC, comparator, adaptive-bias, neural interface
Patent
All spectral frequencies of neural activity reveal semantic representation in the human anterior ventral temporal cortex
Published on 2026-04-17 by @MIT
Abstract: AbstractIntracranial electrophysiology offers a unique insight into the nature of information representation in the brain—it can be used to disentangle information encoded in gamma and high gamma frequencies from information encoded in lower frequencies. We used regularised logistic regression to decode animacy from time-frequency power and phase extracted from electrocorticography (ECoG) grid electrode data recorded on the surface of human ventral anterior temporal lobe (vATL). Power in gamma[...]
Our summary: Neural activity in the anterior ventral temporal cortex encodes semantic information across various spectral frequencies. Intracranial electrophysiology reveals that gamma and high gamma frequencies contribute to reliable decoding of animacy. A broader frequency range enhances decoding accuracy, supporting the concept of a local vATL hub interacting with distributed cortical spokes.
neural activity, semantic representation, electrocorticography, frequency decoding
Publication
Brain-computer interface system and method
Patent published on the 2026-03-26 in WO under Ref WO2026064733 by SCIENCE CORP [US] (Rostov Marat [us], Slager Nate [us], Walker Sage [us], Hodak Max [us], Sharpe Russell [us], Zhou Emma [us], Elsen Antonia [us])
Abstract: Variants of the system can include: a probe and an interface device. Variants of the method can include: configuring a signal pipeline and executing the signal pipeline. In variants, the system and/or method can function to record neural signals from a variety of brain-computer interface (BCI) probe devices. In a specific example, the system and/or method can enable high bandwidth neural recording and processing for BCI experiments.[...]
Our summary: The content describes a brain-computer interface system and method that includes a probe and an interface device. It details the configuration and execution of a signal pipeline to record neural signals from BCI devices. The system aims to enable high bandwidth neural recording and processing for BCI experiments.
brain-computer interface, neural signals, signal pipeline, high bandwidth
Patent
A novel hybrid BCI system combining single-channel SSVEP and PLR to improve classification accuracy and ITR
Published on 2026-03-24 by @OXFORD
Abstract: AbstractSteady-state visual evoked potential (SSVEP)-based brain–computer interfaces (BCIs) have been widely studied because they provide high classification accuracy and information transfer rate (ITR) without requiring user training. To further enhance BCI performance, this study proposes a novel hybrid BCI that integrates single-channel SSVEP with the pupillary light reflex (PLR). Twelve healthy subjects participated in experiments involving three paradigms: SSVEP, PLR, and hybrid. Each sub[...]
Our summary: This study presents a hybrid BCI system that combines single-channel SSVEP and PLR to enhance classification accuracy and information transfer rate. The hybrid paradigm achieved a classification accuracy of 95.70%, outperforming both SSVEP and PLR methods. Results indicate that this approach can significantly improve BCI performance, potentially facilitating broader adoption.
BCI, SSVEP, PLR, classification
Publication
