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Mechanochemical synthesis of histamine h1-receptor antagonists
Patent published on the 2025-06-26 in WO under Ref WO2025136243 by CENTRE NATIONAL DE LA RECHERCHE SCIENT [FR] (Aydonat Simay [tr], Ozel Mertcan [tr], Yigitbasi Joanna Marianna [tr], Baytekin Bilge [tr], Colacino Evelina [fr])
Abstract: The present invention relates to mechanochemical synthesis of histamine antagonists which are benzhydryl ethers and unsymmetrically disubstitutes piperazines and salts thereof. Said antihistamine active pharmaceutical ingredients can be diphenhydramine hydrochloride, cyclizine hydrochloride and diphenylpyraline hydrochloride. These antihistamines are used in the treatment of allergies, hives, hay fever (allergic rhinitis), conjunctivitis, reactions to insect bites and sings, nausea, motion sickn[...]
Our summary: Synthesis of histamine antagonists using mechanochemical methods, including benzhydryl ethers and unsymmetrically disubstituted piperazines, for treatment of allergies, hives, and other conditions.
Mechanochemical synthesis, histamine h1-receptor antagonists, benzhydryl ethers, unsymmetrically disubstituted piperazines
Patent
Cof film solid electrolyte, manufacturing method thereof, and lithium secondary battery comprising same
Patent published on the 2025-06-05 in WO under Ref WO2025116322 by KOREA ADVANCED INSTITUTE OF SCIENCE AND TECH [KR] (Byon Hye Ryung [kr], Choi Rak Hyeon [kr])
Abstract: The present invention relates to: a solid electrolyte for a lithium secondary battery; and a lithium secondary battery comprising same, the solid electrolyte comprising a covalent organic framework (COF) film solid electrolyte represented by chemical formula 1, having unit structures linked by a beta ketoenamine functional group, and comprising a lithium sulfonate functional group.[...]
Our summary: The invention discloses a COF film solid electrolyte for lithium secondary batteries, manufactured using a specific method, and incorporated into a lithium secondary battery.
COF film solid electrolyte, manufacturing method, lithium secondary battery
Patent