
La ricerca di guadagno di funzione (GoFR, Gain-of-Function Research) prevede la modifica mirata di agenti biologici per alterare specifici tratti fenotipici, come la trasmissibilità, la virulenza o la gamma di ospiti. Questa disciplina impiega la genetica inversa, la mutagenesi sito-diretta e il passaggio seriale per studiare i fattori molecolari che guidano l'evoluzione virale e il passaggio zoonotico.
Identificando le mutazioni che consentono l'elusione del sistema immunitario o l'adattamento tra specie diverse, gli scienziati prevedono le minacce pandemiche e accelerano la progettazione di contromisure mediche.
Questo indice sottostante aggrega le pubblicazioni recenti sottoposte a revisione paritaria e brevetto Documenti depositati, che attestano i progressi tecnici nella genomica sintetica e nell'ingegneria virale. Queste voci delineano lo stato dei patogeni potenzialmente pandemici potenziati (ePPP) nell'ambito dei vincoli normativi relativi alla supervisione della ricerca a duplice uso e ai protocolli di biosicurezza.
Questa è la nostra ultima selezione di pubblicazioni e brevetti mondiali in inglese su Gain-of-Function, tra numerose riviste scientifiche online, classificate e focalizzate su passaggi seriali, ricerca a duplice uso di interesse, guadagno di funzione, potenziale patogeno pandemico migliorato, P3CO, miglioramento della patogenicità, miglioramento della trasmissibilità, espansione dell'ospite, tropismo virale, mutagenesi sito-diretta, genetica inversa, genomica sintetica, pressione selettiva, mutante di fuga, scheletro virale, modificazione della proteina spike, affinità di legame del recettore, potenziale di spillover zoonotico, livello di biosicurezza 4, supervisione della biosicurezza, gestione del biorischio, infezione acquisita in laboratorio, virus chimerico, salvataggio virale, inserimento del sito di clivaggio della furina, adattamento in vivo, GoFR e guadagno di funzione.
Lithium metal manufacturing using mask layer
Patent published on the 2026-06-11 in US under Ref US20260158765 by SOELECT INC [US] (Cho Sungjin [us])
Abstract: The present disclosure provides a patterned film for guiding lithium metal during lamination, including first and second regions having different thicknesses configured to direct selective placement, deformation, separation, and transfer of lithium metal onto substrates during roll pressing without mechanical slitting, punching, notching, or trimming. The patterned film may include concave configurations where thin regions form recessed cavities between thick regions, or convex configurations wh[...]
Our summary: The disclosure outlines a patterned film that guides lithium metal during lamination. It features regions of varying thickness to control the placement and transfer of lithium without mechanical processes. Methods include roll pressing to direct lithium according to the film s geometry for effective substrate transfer.
Lithium metal, patterned film, roll pressing, substrate transfer
Patent
Muscle-Specific DNM2 Overexpression Improves Charcot–Marie–Tooth Disease In Vivo and Reveals a Narrow Therapeutic Window in Skeletal Muscle
Published on 2026-02-02 by Marie Goret, Gwenaelle Piccolo, Jocelyn Laporte @MDPI
Abstract: Charcot–Marie–Tooth disease (CMT), caused by dominant loss-of-function mutations in DNM2, encoding the GTPase dynamin-2, impairs motor and sensory function. However, the respective contributions of muscle and nerve pathology, and the therapeutic potential of increasing DNM2 expression, remain unresolved. We evaluated tissue-targeted and systemic approaches to increase DNM2 in a mouse model carrying the common K562E-CMT mutation. Muscle-specific DNM2 overexpression fro[...]
Our summary: Muscle-specific DNM2 overexpression improves symptoms in a mouse model of Charcot-Marie-Tooth disease. Systemic delivery of DNM2 worsens muscle pathology despite increased expression. Findings emphasize the importance of precise DNM2 dosage for effective treatment and highlight a narrow therapeutic window.
DNM2, Charcot-Marie-Tooth, muscle pathology, therapeutic window
Publication
Sublethal Antibiotic Exposure Induces Microevolution of Quinolone Resistance in Pathogenic Vibrio parahaemolyticus
Published on 2026-01-30 by Qian Wu, Han Yang, Tianming Xu, Pradeep K. Malakar, Huan Li, Yong Zhao @MDPI
Abstract: The microevolutionary pathways and molecular mechanisms by which the important pathogen Vibrio parahaemolyticus acquires resistance in the aquatic environment under continuous selective pressure from quinolone antibiotic residues are still unknown. Here, the study successfully simulated the long-term pressure of antibiotic residues in aquaculture by susceptible V. parahaemolyticus (VPD14) which was isolated from seafood, to a 30-day in vitro induction with sublethal concentrations of levofloxaci[...]
Our summary: Sublethal exposure to quinolone antibiotics induces microevolution in Vibrio parahaemolyticus. Mutants exhibit resistance to multiple antibiotics and adaptations such as decreased growth rates. Whole-genome sequencing reveals key mutations in resistance-determining regions associated with this resistance.
Microevolution, Quinolone Resistance, Vibrio parahaemolyticus, Antibiotic Exposure
Publication











