Questa è la nostra ultima selezione di pubblicazioni e brevetti mondiali in inglese su Biotechnology e CRISPR, tra numerose riviste scientifiche online, classificate e focalizzate su CRISPR, editing genico, gRNA, sequenza PAM, clivaggio del DNA, proteina Cas9, editing del genoma, inserimento genico e knockout genico.
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Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a
Patent published on the 2025-05-21 in EP under Ref EP4556567 by FELDAN BIO INC [CA] (Del'guidice Thomas [ca], Lepetit-stoffaes Jean-pascal [ca], Guay David [ca])
Abstract: The present description relates to methods for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell. The methods involve contacting the cell with the polypeptide cargo in the presence of a peptide shuttle agent at a concentration sufficient to increase the polypeptide cargo's transduction efficiency. Also described here are parameters that may be used in the rational design of such synthetic peptide shuttle agents, peptide shuttle ag[...]
Our summary: Methods for delivering polypeptide cargos using synthetic peptide shuttle agents to increase transduction efficiency in target eukaryotic cells. Parameters for rational design, shuttle agents satisfying design parameters, and compositions for delivering various polypeptide cargos are also discussed. Applications and targets for genome-editing NK cells for improved immunotherapy are included.
synthetic peptide, shuttle agents, polypeptide cargos, transduction efficiency
Patent
Genome editing of plant jaz genes for pathogen resistance and improved fiber quality and yield
Patent published on the 2025-03-06 in WO under Ref WO2025050099 by TEXAS TECH UNIV SYSTEM [US] (Rock Chris [us], Sukumaran Sunitha [us])
Abstract: Embodiments of the present disclosure pertain to a plant or seed that includes one or more altered JASMONATE-ZIM DOMAIN repressor (JAZ) genes. Additional embodiments of the present disclosure pertain to methods of altering one or more JAZ genes of a plant or seed by introducing one or more alterations to the one or more JAZ genes of the plant or seed. The altered plants and seeds of the present disclosure may exhibit one or more altered properties, such as jasmonic acid (JA) insensitivity, enhan[...]
Our summary: Genome editing of plant JAZ genes for pathogen resistance and improved fiber quality and yield. Altered plants and seeds with enhanced resistance to pathogens and insects, and improved fiber yield and quality.
Genome editing, Plant, JAZ genes, Pathogen resistance
Patent
