Product Design, Manufacturing & Innovation Resources

Publicações recentes e patentes em biologia sintética

Biologia sintética

Dica: além da seleção abaixo, você pode pesquisar e filtrar nossos 2 bancos de dados completos:

> ferramenta de busca de publicações gratuitas < Por autor, tópico, palavras-chave, data ou periódico.

> ferramenta gratuita de busca de patentes < para patentes em inglês do Escritório Europeu de Patentes.

Synthetic biology
A biologia sintética aproveita a engenharia e biologia molecular Inovar e modificar sistemas biológicos para diversas aplicações.

A biologia sintética integra princípios de engenharia e biologia molecular para projetar, construir e modificar sistemas biológicos com novas funções. Envolve a montagem de partes genéticas padronizadas, a construção de circuitos genéticos sintéticos e a reprogramação do metabolismo celular para criar organismos ou componentes biológicos personalizados. As técnicas incluem edição genômica, síntese de DNA e otimização de vias metabólicas para desenvolver aplicações em terapêutica, biocombustíveis, biossensores e biofabricação. Este domínio aprofunda a compreensão da complexidade biológica por meio da criação de sistemas ortogonais, células mínimas e redes regulatórias sintéticas. A seguir, apresentamos uma compilação de publicações e patentes recentes que detalham inovações em ferramentas, metodologias e aplicações dentro da biologia sintética:

Esta é a nossa mais recente seleção de publicações e patentes mundiais em inglês sobre Biologia Sintética, provenientes de diversos periódicos científicos online, classificadas e focadas em circuitos genéticos, engenharia metabólica, síntese de DNA, edição genômica, CRISPR Cas9, genoma sintético, biobrick, componentes genéticos, engenharia de proteínas, chassis celulares, biossensores, otimização de vias metabólicas, controle da expressão gênica, promotores sintéticos, dispositivos de RNA, células mínimas, sistemas ortogonais, interruptores genéticos, operons sintéticos, vias metabólicas, evolução dirigida, redes regulatórias sintéticas, montagem de DNA, sistemas acelulares, transcrição sintética, expansão do código genético, biologia sintética, análise de fluxo metabólico, genes sintéticos e estratégias de biocontenção.

Electrode, biosensor, and electrode manufacturing method

Patent published on the 2026-07-02 in WO under Ref WO2026140553 by NITTO DENKO CORP [JP] (Fukuda Keita [jp], Yamashita Takayuki [jp], Kamano Yusuke [jp])

Abstract: This electrode comprises a substrate film and a conductive carbon layer in this order toward one side in the thickness direction. The electrode satisfies expression. Expression: 0.30[...]


Our summary: This content discusses an electrode that consists of a substrate film and a conductive carbon layer. It highlights a specific manufacturing method for the electrode. The electrode meets a defined expression value of 0.30.

Electrode, biosensor, conductive carbon, substrate film

Patent

Systems and methods for estrogen biosensing

Patent published on the 2026-06-25 in US under Ref US20260176666 by BIOSENS8 INC [US] (Kuzmanovic Uros [us], Charles Jr Roger J [us], Davis Connor A [us])

Abstract: The present disclosure generally relates to enzyme-based biosensors and, in particular, to biosensors for determining estrogen and other biomolecules. In some cases, the enzymes may be based on dehydrogenases, such as 17-beta hydroxysteroid dehydrogenases. In certain embodiments, the enzyme may include an active site that is able to bind to and oxidize estrogen, or other biomolecules. In some cases, the active site may include certain residues positioned around the active site that are able to s[...]


Our summary: The disclosure describes enzyme-based biosensors for detecting estrogen and other biomolecules. It focuses on dehydrogenases that oxidize estrogen through specific active sites. Methods for creating and utilizing these biosensors and related kits are also discussed.

biosensors, estrogen, dehydrogenases, enzyme-based

Patent

Expanded metabolic pathway for androgen production by commensal bacteria

Patent published on the 2026-06-25 in US under Ref US20260177553 by THE BRD OF TRUSTEES OF THE UNIV OF ILLINOIS [US] (Ridlon Jason M [us])

Abstract: [0000] Provided herein is the first commensal microbial gene encoding an enzyme that catalyzes the conversion of androstenedione to epitestosterone in the gut bacterium Clostridium scindens (desF). Also provided is an important and unrecognized capability for epitestosterone in androgen receptor-dependent prostate cancer cell proliferation and the potential clinical relevance of this bacterial enzymatic pathway (desF) in prostate cancer. Additionally, it was discovered that bacterial isolates fr[...]


Our summary: A novel microbial gene (desF) in Clostridium scindens converts androstenedione to epitestosterone. This pathway is linked to prostate cancer cell proliferation. Additionally, urinary isolates demonstrate the ability to produce androgens through the enzyme 17β-hydroxysteroid dehydrogenase (desG).

androgen production, commensal bacteria, Clostridium scindens, prostate cancer

Patent

Biosensor device

Patent published on the 2026-06-18 in WO under Ref WO2026127530 by WISOL CO LTD [KR] (Kim Jung Min [kr], Lee Ho Sub [kr])

Abstract: A biosensor device according to the present invention comprises: a printed circuit board in which at least one sample seating hole for seating a test sample is formed to have a hollow structure; a biosensor which is coupled to a position corresponding to the sample seating hole on the lower surface of the printed circuit board, and senses a sample reaction of the test sample; and a case having an inner space for accommodating the printed circuit board.[...]


Our summary: The biosensor device features a printed circuit board with a hollow sample seating hole. It includes a biosensor positioned beneath the hole to detect sample reactions. The device is housed in a case that accommodates the printed circuit board.

biosensor, printed circuit board, sample seating hole, test sample

Patent

Human cell-free system for high-throughput screening for new compounds for targeted protein degradation

Patent published on the 2026-06-17 in EP under Ref EP4759936 by FRAUNHOFER GES FORSCHUNG [DE] (Hahnengress Nils [de], Buntru Matthias [de])

Abstract: The present invention relates to a cell lysate wherein the lysis buffer comprises at least one of magnesium acetate, phosphorylation inhibitor K3L, an agonist of dephosphorylation GADD34 and/or a caspase inhibitor for use in, or as, a cell-free system and a method for preparing a cell-free protein synthesis system. Further provided is a method for expressing a protein in the cell-free protein synthesis system, a method for screening for a candidate compound for an effect on a target molecule and[...]


Our summary: The invention describes a human cell-free system for high-throughput screening of compounds targeting protein degradation. It includes a cell lysate with specific components for enhanced protein synthesis. Additionally, methods for expressing proteins and screening candidate compounds are provided, along with a related kit.

cell-free system, high-throughput screening, targeted protein degradation, protein synthesis

Patent

Spot drops biosensor nutrient management

Patent published on the 2026-06-11 in WO under Ref WO2026122877 by SOUTH DAKOTA BOARD OF REGENTS [US] (Khalid Ahmed [us], Mirzaee Salman [us], Mirzakhani Nafchi Ali [us], Kumari Karishma [us])

Abstract: Disclosed herein are methods and systems of detecting nutrient deficiencies in an agricultural field and creating a variable rate fertilizer application map by analyzing a field for standard vegetation markers, creating a management zone map having management zones based on the standard vegetation markers, wherein the management zones are assigned based on commonality in the standard vegetation markers. Applying a standard nutrient fertilizer to the field, assigning a plurality of biosensor rich[...]


Our summary: The system detects nutrient deficiencies in agricultural fields using biosensors. It creates a variable rate fertilizer application map based on vegetation markers and management zones. Fertilizer is applied variably using controlled spray nozzles to optimize yield.

biosensor, nutrient management, variable rate application, agricultural technology

Patent

Ethical and Clinical Best Practices for Genome Editing Applications

Published on 2026-02-02 by Mara Ortiz-Bueno, Federica Zinghirino, Pilar Puig Serra, Kyriaki Paschoudi, Lluis Montoliu, Erden Atilla, Yonglun Luo, Alessia Cavazza, Carsten W. Lederer, Karim Benabdellah @MDPI

Abstract: Genome editing (GE) has transformed medicine by allowing precise changes to DNA, offering potential treatments for a range of inherited and acquired disorders. Several technologies support these advances, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-based systems, of which the latter has emerged as the most accessible, versatile, and popular. While GE holds great promise, i[...]


Our summary: Genome editing technologies enable precise DNA modifications for medical treatments. Ethical and regulatory considerations are crucial for safe clinical applications. Regulatory agencies provide guidance on safety, consent, and compliance in genome editing practices.

Genome Editing, Ethical Standards, Regulatory Compliance, Clinical Applications

Publication

Bacillus velezensis Enhances Rice Resistance to Brown Spot by Integrating Antifungal and Growth Promotion Functions

Published on 2026-02-01 by Elizabeth B. E. Pires, Maira S. Tique Obando, Luis Janssen, Bergmann M. Ribeiro, Odaiza F. Souza, Marcelo L. Dias, Lus O. Viteri Jumbo, Rodrigo R. Fidelis, Gil R. Santos, Raimundo N. C. Rocha, Guy Smagghe, Tito Bacca, Eugenio E. Oliveira, Rudolf Haumann, Raimundo W. S. Aguiar @MDPI

Abstract: Brown spot, caused by the seedborne fungus Bipolaris oryzae, remains a major constraint in rice production. Here, we used in vitro and in vivo assays to evaluate the biocontrol potential of three Bacillus strains (Ba. cereus OQ725688.1, Ba. velezensis OP938696.1, and Ba. subtilis OP937353.1) against Bi. oryzae in two rice cultivars (&amp;ldquo;Rubelita&amp;rdquo; and &amp;ldquo;Predileta&amp;rdquo;). Ba. cereus showed the highest in vitro mycelial inhibition (&amp;asymp;95%),[...]


Our summary: Bacillus velezensis enhances rice resistance to brown spot by integrating antifungal and growth promotion functions. It effectively reduces disease severity and increases seedling vigor compared to infected controls. The strain exhibits unique biochemical traits and potential for sustainable rice protection strategies.

Bacillus velezensis, biocontrol, rice resistance, antifungal

Publication

Tópicos abordados: Biologia sintética, engenharia, biologia molecular, componentes genéticos, circuitos genéticos sintéticos, metabolismo celular, edição genômica, síntese de DNA, otimização de vias metabólicas, terapêutica, biocombustíveis, biossensores, biofabricação, sistemas ortogonais, células mínimas, redes regulatórias sintéticas, ISO 22174, ISO 16140, ISO 20391, ISO 13485 e ASTM E2875.

Glossário de termos utilizados

Deoxyribonucleic Acid (DNA): Uma molécula composta por duas cadeias que formam uma dupla hélice, constituída por nucleotídeos que codificam informações genéticas através de sequências de quatro bases: adenina, timina, citosina e guanina. Ela serve como material hereditário na maioria dos organismos vivos.

Contexto histórico

2000
2002
2010
2013
2000
2000
2003
2010
2013-09-24

(Caso a data seja desconhecida ou irrelevante, por exemplo, "mecânica dos fluidos", é fornecida uma estimativa aproximada de seu surgimento notável)

Imagens em tamanho real e downloads estão disponíveis apenas, 100% gratuitos, para membros registrados.