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Publicações recentes e patentes em biologia sintética

Biologia sintética

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Synthetic biology
A biologia sintética aproveita a engenharia e biologia molecular Inovar e modificar sistemas biológicos para diversas aplicações.

A biologia sintética integra princípios de engenharia e biologia molecular para projetar, construir e modificar sistemas biológicos com novas funções. Envolve a montagem de partes genéticas padronizadas, a construção de circuitos genéticos sintéticos e a reprogramação do metabolismo celular para criar organismos ou componentes biológicos personalizados. As técnicas incluem edição genômica, síntese de DNA e otimização de vias metabólicas para desenvolver aplicações em terapêutica, biocombustíveis, biossensores e biofabricação. Este domínio aprofunda a compreensão da complexidade biológica por meio da criação de sistemas ortogonais, células mínimas e redes regulatórias sintéticas. A seguir, apresentamos uma compilação de publicações e patentes recentes que detalham inovações em ferramentas, metodologias e aplicações dentro da biologia sintética:

Esta é a nossa mais recente seleção de publicações e patentes mundiais em inglês sobre Biologia Sintética, provenientes de diversos periódicos científicos online, classificadas e focadas em circuitos genéticos, engenharia metabólica, síntese de DNA, edição genômica, CRISPR Cas9, genoma sintético, biobrick, componentes genéticos, engenharia de proteínas, chassis celulares, biossensores, otimização de vias metabólicas, controle da expressão gênica, promotores sintéticos, dispositivos de RNA, células mínimas, sistemas ortogonais, interruptores genéticos, operons sintéticos, vias metabólicas, evolução dirigida, redes regulatórias sintéticas, montagem de DNA, sistemas acelulares, transcrição sintética, expansão do código genético, biologia sintética, análise de fluxo metabólico, genes sintéticos e estratégias de biocontenção.

Spot drops biosensor nutrient management

Patent published on the 2026-06-11 in WO under Ref WO2026122877 by SOUTH DAKOTA BOARD OF REGENTS [US] (Khalid Ahmed [us], Mirzaee Salman [us], Mirzakhani Nafchi Ali [us], Kumari Karishma [us])

Abstract: Disclosed herein are methods and systems of detecting nutrient deficiencies in an agricultural field and creating a variable rate fertilizer application map by analyzing a field for standard vegetation markers, creating a management zone map having management zones based on the standard vegetation markers, wherein the management zones are assigned based on commonality in the standard vegetation markers. Applying a standard nutrient fertilizer to the field, assigning a plurality of biosensor rich[...]


Our summary: The system detects nutrient deficiencies in agricultural fields using biosensors. It creates a variable rate fertilizer application map based on vegetation markers and management zones. Fertilizer is applied variably using controlled spray nozzles to optimize yield.

biosensor, nutrient management, variable rate application, agricultural technology

Patent

Smart biosensor sensor based on superposition of biopotential and physical signals

Patent published on the 2026-06-11 in WO under Ref WO2026122483 by SAN DIEGO STATE UNIV RESEARCH FOUNDATION [US] (Moon Kee Suk [us], Lee Sung Q [us])

Abstract: In some embodiments, there may be provided an apparatus including a first sensor element comprising a first electrode and a second sensor element comprising a second electrode and a piezoelectric sensor. The apparatus may include or be coupled to at least one processor coupled to the first element and the second element, the at least one processor configured to separate, based on at least on frequency, the at least one biopotential signal and the at least one acoustic signal obtained from vibrat[...]


Our summary: The apparatus includes two sensor elements for biopotential and acoustic signal detection. A processor separates these signals based on frequency. The system derives indicators related to the wearer from the processed signals.

biosensor, biopotential, piezoelectric, signal processing

Patent

Method for enhancing plant transformation efficiency by using agrobacterium carrying virg mutant gene and nahg gene

Patent published on the 2026-06-11 in US under Ref US20260159848 by NULLA BIO INC [KR] (Jeon Eun-young [kr], Jeong Jin-hee [kr])

Abstract: [0000] A method for enhancing transformation efficiency of a plant includes transforming a plant cell with a bacteria of the genus Agrobacterium carrying virGgene and NahG (salicylate hydroxylase) gene. The method is based on the discovery that introducing both a constitutively active virG mutant gene (virG) and a salicylic acid-degrading gene (NahG) into an Agrobacterium strain synergistically increases its ability to deliver a target gene into a plant cell. The provided strains can be used to [...]


Our summary: The method enhances plant transformation efficiency by using Agrobacterium with a virG mutant and NahG gene. This approach improves gene delivery into plant cells. It is applicable to various plant species, including those that are typically difficult to transform.

Agrobacterium, plant transformation, virG gene, NahG gene

Patent

Cellular iron biosensors

Patent published on the 2026-06-03 in EP under Ref EP4752155 by UNIV GRAZ MEDIZINISCHE [AT] (Akyol Ali [at], Graier Wolfgang [at], Malli Roland [at])

Abstract: The present invention relates to genetically encoded cellular iron biosensors, in particular to nucleic acids encoding the same, vectors and cells comprising the nucleic acid(s), in vitro methods for measuring, and optionally monitoring, cellular Fe2+ and/or cellular iron-sulfur cluster (ISC), in vitro screening methods for a compound that affects cellular Fe2+ and/or cellular ISC, and to in vitro methods for identifying a dosage and/or formulation of a compound that affects cellular Fe2+ and/or[...]


Our summary: This invention describes genetically encoded cellular iron biosensors. It includes nucleic acids, vectors, and cells for measuring cellular Fe2+ and iron-sulfur clusters. Additionally, it outlines methods for screening compounds that affect cellular iron levels and identifying optimal dosages.

iron biosensors, genetically encoded, cellular Fe2+, in vitro methods

Patent

Enhanced resuscitation for emergency care

Patent published on the 2026-06-03 in EP under Ref EP4751767 by KONINKLIJKE PHILIPS NV [NL] (Berman Randall M [nl], Fujito Keiichi [nl], Arbanas Brian [nl], Jorgenson Dawn Blilie [nl], Frosh Karl [nl], Gehman Stacy Earl [nl], Szymanski Joyce Ann [nl], Burns Delaney [nl], Evans Dave [nl], Riemer Adena [nl], De Lat Bente [nl])

Abstract: [0001] A defibrillation system employs one or more of a wearable biosensor configured to monitor a ventilation of the patient, a wearable injector configured to administer a medication to the patient, a digital stethoscope configured to monitor a heart of the patient; and ambient sensor (70, 80)(s) configured to monitor ambient sound and/or ambient light. The defibrillation system further employs a defibrillator including a defibrillation controller configured to implement a resuscitation protoc[...]


Our summary: The defibrillation system integrates multiple wearable sensors to monitor patient ventilation, heart activity, and ambient conditions. It includes a wearable injector for medication administration. The system s controller implements a resuscitation protocol based on real-time data from these devices.

defibrillation, biosensor, resuscitation, monitoring

Patent

Biosensor and module for detecting target substance in body fluid

Patent published on the 2026-05-28 in WO under Ref WO2026111559 by LMK CO LTD [KR] (Kim Sung Il [kr], Myung Hyun Sik [kr], Lee Jong Geun [kr], Lee Kyo Wung [kr])

Abstract: The present invention relates to a biosensor and a biomodule, for detecting a target substance in a body fluid, which are capable of collecting a body fluid such as saliva, urine, or blood from an examinee to detect a target substance (for example, a hormone) in the body fluid, and performing diagnosis based on a level thereof. The biosensor for detecting a target substance in a body fluid, according to the present invention, is for detecting a target substance in a body fluid of an examinee, an[...]


Our summary: The invention describes a biosensor and biomodule for detecting target substances in body fluids like saliva, urine, or blood. It features a substrate with an electrode and a hydrogen-free carbon thin film that includes an immobilized material matching the target substance. The detection process is based on analyzing XPS peak intensities related to carbon bonds in the thin film.

Biosensor, Body fluid, Carbon thin film, Target substance

Patent

Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products

Published on 2026-03-05 by Osman Mewett, John McMurdy, Lieselot Bertho, Ana Atanassova, Naomi Stevens, Scott Huber, Maria Fedorova, Kevin Diehl, Kevin Tianmeng Zhao @NATURE

Abstract: Nature Biotechnology, Published online: 05 March 2026; doi:10.1038/s41587-026-03028-0Site-directed nuclease (SDN) classification into SDN-1, SDN-2 and SDN-3 outcomes is used for regulating genome-edited plant products in some countries. This reductive categorization system fails to cover the breadth of genome editing technologies developed over the past decade and their rapidly approaching commercial use. Here, we argue that, in the context of plant breeding, regulations should focus on the char[...]


Our summary: The current classification of site-directed nucleases (SDNs) is inadequate for regulating genome-edited plants. A shift towards an outcome-focused regulatory approach is proposed to enhance oversight and efficiency. This change aims to address challenges in crop improvement related to climate change and pest resistance.

genome editing, site-directed nucleases, regulatory framework, plant breeding

Publication

Ethical and Clinical Best Practices for Genome Editing Applications

Published on 2026-02-02 by Mara Ortiz-Bueno, Federica Zinghirino, Pilar Puig Serra, Kyriaki Paschoudi, Lluis Montoliu, Erden Atilla, Yonglun Luo, Alessia Cavazza, Carsten W. Lederer, Karim Benabdellah @MDPI

Abstract: Genome editing (GE) has transformed medicine by allowing precise changes to DNA, offering potential treatments for a range of inherited and acquired disorders. Several technologies support these advances, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-based systems, of which the latter has emerged as the most accessible, versatile, and popular. While GE holds great promise, i[...]


Our summary: Genome editing technologies enable precise DNA modifications for medical treatments. Ethical and regulatory considerations are crucial for safe clinical applications. Regulatory agencies provide guidance on safety, consent, and compliance in genome editing practices.

Genome Editing, Ethical Standards, Regulatory Compliance, Clinical Applications

Publication

Tópicos abordados: Biologia sintética, engenharia, biologia molecular, componentes genéticos, circuitos genéticos sintéticos, metabolismo celular, edição genômica, síntese de DNA, otimização de vias metabólicas, terapêutica, biocombustíveis, biossensores, biofabricação, sistemas ortogonais, células mínimas, redes regulatórias sintéticas, ISO 22174, ISO 16140, ISO 20391, ISO 13485 e ASTM E2875.

Glossário de termos utilizados

Deoxyribonucleic Acid (DNA): Uma molécula composta por duas cadeias que formam uma dupla hélice, constituída por nucleotídeos que codificam informações genéticas através de sequências de quatro bases: adenina, timina, citosina e guanina. Ela serve como material hereditário na maioria dos organismos vivos.

Contexto histórico

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(Caso a data seja desconhecida ou irrelevante, por exemplo, "mecânica dos fluidos", é fornecida uma estimativa aproximada de seu surgimento notável)

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