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Mechanochemical synthesis of histamine h1-receptor antagonists
Patent published on the 2025-06-26 in WO under Ref WO2025136243 by CENTRE NATIONAL DE LA RECHERCHE SCIENT [FR] (Aydonat Simay [tr], Ozel Mertcan [tr], Yigitbasi Joanna Marianna [tr], Baytekin Bilge [tr], Colacino Evelina [fr])
Abstract: The present invention relates to mechanochemical synthesis of histamine antagonists which are benzhydryl ethers and unsymmetrically disubstitutes piperazines and salts thereof. Said antihistamine active pharmaceutical ingredients can be diphenhydramine hydrochloride, cyclizine hydrochloride and diphenylpyraline hydrochloride. These antihistamines are used in the treatment of allergies, hives, hay fever (allergic rhinitis), conjunctivitis, reactions to insect bites and sings, nausea, motion sickn[...]
Our summary: Synthesis of histamine antagonists using mechanochemical methods, including benzhydryl ethers and unsymmetrically disubstituted piperazines, for treatment of allergies, hives, and other conditions.
Mechanochemical synthesis, histamine h1-receptor antagonists, benzhydryl ethers, unsymmetrically disubstituted piperazines
Patent
Cof film solid electrolyte, manufacturing method thereof, and lithium secondary battery comprising same
Patent published on the 2025-06-05 in WO under Ref WO2025116322 by KOREA ADVANCED INSTITUTE OF SCIENCE AND TECH [KR] (Byon Hye Ryung [kr], Choi Rak Hyeon [kr])
Abstract: The present invention relates to: a solid electrolyte for a lithium secondary battery; and a lithium secondary battery comprising same, the solid electrolyte comprising a covalent organic framework (COF) film solid electrolyte represented by chemical formula 1, having unit structures linked by a beta ketoenamine functional group, and comprising a lithium sulfonate functional group.[...]
Our summary: The invention discloses a COF film solid electrolyte for lithium secondary batteries, manufactured using a specific method, and incorporated into a lithium secondary battery.
COF film solid electrolyte, manufacturing method, lithium secondary battery
Patent
Developable interventional guidewire for hyperpolarized 129xe magnetic resonance imaging and preparation method thereof
Patent published on the 2025-05-29 in US under Ref US2025170370 by INNOVATION ACADEMY FOR PRECISION MEASUREMENT SCIENCE AND TECH CAS [CN] (Guo Qianni [cn], Yang Xinxin [cn], Zeng Qingbin [cn], Zhou Xin [cn])
Abstract: The present invention relates to the technical field of medical devices, and in particular, to a developable interventional guidewire for hyperpolarized 129Xe MRI and a preparation method thereof. The interventional guidewire includes a guidewire body, a cladding layer wrapped around a surface of the guidewire body, a Zn(II)-PDA modified layer adhered to a surface of the cladding layer, and a developing film layer coated on the Zn(II)-PDA modified layer. The Zn(II)-PDA modified layer is introduc[...]
Our summary: Developable interventional guidewire for hyperpolarized 129xe MRI, includes Zn(II)-PDA modified layer, preparation method involves solvothermal synthesis, dense ZIF-8 film layer coated.
interventional guidewire, hyperpolarized 129Xe MRI, preparation method, Zn(II)-PDA modified layer
Patent
Copolymers and processes for recyclable polymer material using enamine-covalent adaptable networks
Patent published on the 2025-03-20 in WO under Ref WO2025059655 by FLO MAT INC [US] (Cheng Kezi [us], Gopalakrishnan Deepti [us], Dikshit Karan Vivek [us], Christensen Peter R [us], Naik Durva [us])
Abstract: A polymer composition platform with a wide range of architectures and properties is described. The composition comprises dynamic covalent chemistry to form polymer compositions that may be chemically recycled to monomer constituents at end of life. A composition as described may be copolymerized with a wide range of common polymers to introduce or enhance attributes like recyclability.[...]
Our summary: Polymer composition platform with diverse architectures and properties, chemically recyclable polymer compositions, copolymerization with common polymers to enhance recyclability.
copolymers, recyclable polymer material, enamine-covalent adaptable networks, dynamic covalent chemistry
Patent
Materials and processes for material forms using enamine-covalent adaptable networks
Patent published on the 2025-03-20 in WO under Ref WO2025059659 by FLO MAT INC [US] (Naik Durva [us], Gopalakrishnan Deepti [us], Cheng Kezi [us], Dikshit Karan Vivek [us], Christensen Peter R [us])
Abstract: A polymer composition platform with a wide range of architectures and properties is described. The composition employs dynamic covalent chemistry to form polymer compositions that may be chemically recycled to monomer constituents at end of life. The polymers may be manufactured as fibers, elastomers, coatings, adhesives, sheets, etc. that are more easily and efficiently recycled than common plastics.[...]
Our summary: Materials and processes for material forms using enamine-covalent adaptable networks. A polymer composition platform with a wide range of architectures and properties is described. The composition employs dynamic covalent chemistry to form polymer compositions that may be chemically recycled to monomer constituents at end of life. The polymers may be manufactured as fibers, elastomers, coatings, adhesives, sheets, etc. that are more easily and efficiently recycled than common plastics.
enamine-covalent adaptable networks, polymer composition platform, dynamic covalent chemistry, chemically recycled
Patent
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