Synthetic biology integrates engineering principles with molecular biology to construct novel biological systems and redesign existing ones. Gene circuit design and genome editing techniques, including CRISPR-Cas systems, enable precise manipulation of genetic material. Metabolic pathway engineering optimizes biochemical production, while synthetic gene networks facilitate programmable cellular behavior. Advances in DNA synthesis and protein engineering expand functional capabilities. Cell-free synthetic biology platforms accelerate prototyping of genetic constructs. Biosensors and genetic toggle switches provide dynamic control and environmental responsiveness. Orthogonal ribosomes and synthetic promoters enhance specificity and modularity.
This is our latest selection of worldwide publications and patents in english on Synthetic Biology, between many scientific online journals, classified and focused on synthetic biology, gene circuit design, genome editing, CRISPR-Cas, metabolic pathway engineering, synthetic gene network, DNA synthesis, protein engineering, cell-free synthetic, biosensor, genetic toggle switch, orthogonal ribosome, minimal genome, synthetic promoters, RNA-based, metabolic flux analysis, directed evolution, synthetic chromosome, biobrick, genetic code expansion, computational synthetic biology, chassis organism, synthetic operon, gene expression modulation, synthetic transcription factor, biofoundries, metabolic engineering, synthetic biology automation, genetic part libraries, synthetic biology standard and biocontainment strategies.
Probe design and electrochemical biomarker detection utilizing reusable polypeptide nucleic acid (pna) based sensors
Patent published on the 2026-05-21 in WO under Ref WO2026107321 by UNIV UTAH RES FOUND [US] (Kim Younghwan [us], Mohanty Swomitra Kumar [us])
Abstract: A biosensor apparatus includes an electrode comprising a surface including at least one of (i) a metal; and (ii) a layer of nanotubes. A plurality of peptide nucleic acid (PNA) probes are complexed to the surface of the electrode. The plurality of PNA probes are structured to bind to one or more biomarkers.[...]
Our summary: This study focuses on designing a biosensor using polypeptide nucleic acid (PNA) probes for electrochemical biomarker detection. The biosensor apparatus features an electrode with a metal surface or nanotube layer. PNA probes are attached to the electrode to selectively bind to specific biomarkers.
biosensor, peptide nucleic acid, electrochemical detection, probe design
Patent
System and method for real-time ai-based medical recommendations
Patent published on the 2026-05-21 in US under Ref US20260142030 by BOYD TIMOTHY [SE] (Gream Bianca [se], Boyd Timothy [se])
Abstract: [0000] A system for generation of medical recommendation based on patient-related data, including a processor of a medical recommendations server (MRS) node configured to host a machine learning (ML) module and connected to a patient entity node and to at least one medical emergency entity node over a network and a memory on which are stored machine-readable instructions that when executed by the processor, cause the processor to: acquire sensory data from a plurality of biosensors encapsulated [...]
Our summary: The system generates medical recommendations using patient-related data. It employs a machine learning module to analyze sensory and patient data. The recommendations are based on historical patient engagements and feature vectors derived from key classifying features.
real-time recommendations, machine learning, biosensors, artificial neural networks
Patent
Device for autonomous measurement in complex samples and for the autonomous extraction of a liquid sample
Patent published on the 2026-05-20 in EP under Ref EP4745572 by HEDBERG ELLINOR [SE] (Roxhed Niclas [se], Stemme GÖran [se], Ribet Federico [se], Hedberg Ellinor [se], GarcÍa Carmona Laura [es], Lucas Garrote Beatriz [es], Vegas GarcÍa Marta [es], GarcÍa Pellicer Marta [es], Quijano LÓpez Alfredo [es])
Abstract: Lateral flow strip for the autonomous realization of chemical and/or biological reactions in a complex liquid sample comprising at least one porous hydrophilic layer, with at least one zone of placement of the liquid sample, where the lateral flow is configured to transport the fluid along the porous hydrophilic layer, characterized in that it includes means of regulating the flow velocity of fluid along the lateral flow strip, configured to regulate the reaction time of the liquid sample in the[...]
Our summary: The device enables autonomous measurement and extraction of liquid samples. It features a lateral flow strip for conducting chemical and biological reactions. The system includes flow regulation and a biosensor for target molecule interaction.
autonomous measurement, lateral flow strip, biosensor, capillarity extraction
Patent
Optimizing optical nano-biosensors made of single-walled carbon nanotubes wrapped in single-stranded sequences of nucleotides for detection of molecul
Patent published on the 2026-05-13 in EP under Ref EP4742248 by ECOLE POLYTECHNIQUE FED LAUSANNE EPFL [CH] (Boghossian Ardemis Anoush [ch], Rabbani Yahya [ch], Bregy Joey [ch])
Abstract: The invention is notably directed to a computer-implemented method of optimizing an optical sensor comprising a single-walled carbon nanotube, or SWCNT for short, which is wrapped in single-stranded sequence of nucleotides (ssSN). The method revolves around two or more optimization cycles. Each optimization cycle includes clustering ssSNs of an input set of ssSNs to obtain clusters and selecting representative ssSNs of the clusters obtained. Next, one accesses measurements of optical responses o[...]
Our summary: The invention optimizes optical nano-biosensors using single-walled carbon nanotubes wrapped in nucleotides. It employs multiple optimization cycles to identify the best single-stranded sequences through clustering and measurement of optical responses. The method includes mutation of top sequences to explore a broader input space for enhanced detection of target molecules.
nano-biosensors, carbon nanotubes, optimization cycles, optical responses
Patent
Protein engineering using a multimodal and retrieval augmented generative model of protein families
Patent published on the 2026-04-23 in US under Ref US20260112447 by NE47 BIO INC [US] (Bepler Tristan [us], Truong Jr Timothy F [us])
Abstract: [0000] A multimodal generative model of protein families is provided to jointly model the sequences and structures of proteins within a protein family. The model is used for controllable protein generation and representation learning. The model leverages in-context learning to infer underlying evolutionary constraints that give rise to the family s characteristic sequence features, structural architectures, and/or functional properties. These inferred evolutionary constraints, coupled with a fle[...]
Our summary: A multimodal generative model is developed to analyze protein family sequences and structures. It enables controllable generation of novel proteins by inferring evolutionary constraints. The model utilizes an encoder-decoder transformer architecture for optimized protein design.
Protein engineering, multimodal generative model, protein families, controllable protein generation
Patent
Recombinant protein l protein with improved alkali resistance and use thereof
Patent published on the 2026-03-19 in WO under Ref WO2026057090 by ACROBIOSYSTEMS AG [CH] (Tian Li [cn], Qin Lili [cn], Chen Lei [cn], Liu Xiaoyu [cn], Wang Lei [cn], Miao Jingyun [cn], Chen Yiding [cn])
Abstract: The present application relates to the technical field of protein engineering, and specifically provides a recombinant Protein L protein with improved alkali resistance and use thereof. The recombinant Protein L protein of the present application has higher stability under alkaline conditions while maintaining high binding ability to immunoglobulins, thereby providing a more efficient and economical method for isolating immunoglobulins.[...]
Our summary: This application presents a recombinant Protein L with enhanced alkali resistance. The protein maintains strong binding to immunoglobulins under alkaline conditions. This advancement offers a more efficient method for isolating immunoglobulins.
Recombinant protein, alkali resistance, protein engineering, immunoglobulin isolation
Patent
Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products
Published on 2026-03-05 by Osman Mewett, John McMurdy, Lieselot Bertho, Ana Atanassova, Naomi Stevens, Scott Huber, Maria Fedorova, Kevin Diehl, Kevin Tianmeng Zhao @NATURE
Abstract: Nature Biotechnology, Published online: 05 March 2026; doi:10.1038/s41587-026-03028-0Site-directed nuclease (SDN) classification into SDN-1, SDN-2 and SDN-3 outcomes is used for regulating genome-edited plant products in some countries. This reductive categorization system fails to cover the breadth of genome editing technologies developed over the past decade and their rapidly approaching commercial use. Here, we argue that, in the context of plant breeding, regulations should focus on the char[...]
Our summary: The current classification of site-directed nucleases (SDNs) is inadequate for regulating genome-edited plants. A shift towards an outcome-focused regulatory approach is proposed to enhance oversight and efficiency. This change aims to address challenges in crop improvement related to climate change and pest resistance.
genome editing, site-directed nucleases, regulatory framework, plant breeding
Publication
Ethical and Clinical Best Practices for Genome Editing Applications
Published on 2026-02-02 by Mara Ortiz-Bueno, Federica Zinghirino, Pilar Puig Serra, Kyriaki Paschoudi, Lluis Montoliu, Erden Atilla, Yonglun Luo, Alessia Cavazza, Carsten W. Lederer, Karim Benabdellah @MDPI
Abstract: Genome editing (GE) has transformed medicine by allowing precise changes to DNA, offering potential treatments for a range of inherited and acquired disorders. Several technologies support these advances, including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-based systems, of which the latter has emerged as the most accessible, versatile, and popular. While GE holds great promise, i[...]
Our summary: Genome editing technologies enable precise DNA modifications for medical treatments. Ethical and regulatory considerations are crucial for safe clinical applications. Regulatory agencies provide guidance on safety, consent, and compliance in genome editing practices.
Genome Editing, Ethical Standards, Regulatory Compliance, Clinical Applications
Publication
