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» 피부 비타민 D 합성

피부 비타민 D 합성

1930
  • Adolf Windaus
  • Kurt Huldschinsky
생화학에서 피부 비타민 D 합성 연구를 묘사한 실험실 장면.

(설명을 위한 생성된 이미지입니다)

Sunlight, specifically 자외선 B (UVB) radiation with wavelengths between 290-315 nm, triggers the synthesis of vitamin D in the skin. When UVB photons strike the skin, they cause the photochemical conversion of 7-dehydrocholesterol into previtamin D3, which is then isomerized into vitamin D3 (cholecalciferol). This process is the primary natural source of vitamin D for humans.

The synthesis of vitamin D is a multi-step process essential for human health. It begins in the epidermis when UVB radiation breaks a chemical bond in 7-dehydrocholesterol, a derivative of cholesterol. The resulting compound, previtamin D3, is thermally unstable and rapidly rearranges itself into vitamin D3 (cholecalciferol). This vitamin D3 is then transported via the bloodstream to the liver, where it undergoes hydroxylation to become calcifediol (25-hydroxyvitamin D). Calcifediol is the main circulating form of vitamin D and is what is typically measured in blood tests. For its final activation, calcifediol travels to the kidneys (and other tissues), where it is converted into calcitriol (1,25-dihydroxyvitamin D), the biologically active form of the vitamin. Calcitriol functions as a hormone, primarily regulating calcium and phosphate levels in the blood, which is critical for bone mineralization. Several factors influence the efficiency of this process, including latitude, season, time of day, skin pigmentation (melanin acts as a natural sunblock), and the use of sunscreen, all of which can modulate the amount of UVB radiation reaching the skin’s precursor molecules.

UNESCO Nomenclature: 2401
– Biochemistry

유형

생화학적 과정

분열

상당한

용법

널리 사용됨

전구체

  • discovery of rickets as a disease
  • identification of ‘fat-soluble factor a’ (later split into vitamins a and d) by elmer mccollum
  • theodor scherfig’s observation of sunlight’s benefits for children’s health
  • advances in organic chemistry allowing for the isolation and structural analysis of sterols

응용 프로그램

  • treatment of rickets and osteomalacia
  • public health recommendations for sun exposure
  • fortification of foods like milk and cereal with vitamin d
  • development of vitamin d supplements
  • uvb phototherapy for skin conditions like psoriasis
  • understanding of calcium metabolism and bone health

특허:

NA

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Related to: vitamin D, UVb radiation, sunlight, skin, 7-dehydrocholesterol, cholecalciferol, rickets, bone health, calcium metabolism, photochemistry.

역사적 맥락

피부 비타민 D 합성

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