This is our latest selection of worldwide publications and patents in english on Microfluidics, between many scientific online journals, classified and focused on microfluidics, microchannel, lab-on-a-chip, capillary action, electrowetting, surface tension, microfabrication and microreactor.
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Isolation and expansion of natural killer cells using fluorescence-activated droplet sorting
Patent published on the 2025-03-06 in WO under Ref WO2025050133 by NORTHEASTERN UNIV [US] (Konry Tania [us], Estevam Jose [us], White Rachel [us])
Abstract: A high-throughput microfluidics-based fluorescence activated droplet sorting (FADS) system provides activation, sorting, and feeder cell-free expansion of NK cells that are enriched for killing activity. The NK cells are activated and identified based on their ability to kill target cells, such as tumor cells, without prior sensitization. The diversity of endogenous NK cells can be overcome to allow selection of a highly effective population of cells for therapeutic use, such as in the treatment[...]
Our summary: High-throughput FADS system for isolation and expansion of NK cells with killing activity, selection of effective NK cell population for cancer treatment, activation and identification of NK cells based on killing ability.
microfluidics, fluorescence-activated droplet sorting, natural killer cells, expansion
Patent
Light valve system with gap maintenance system
Patent published on the 2025-03-06 in WO under Ref WO2025049744 by SEURAT TECH INC [US] (Elhadj Selim [us], Sargolzaeiaval Yasaman [us], Davidson Zoey [us])
Abstract: A light valve can include a liquid crystal layer having a first and a second side. A first substrate is positioned in contact with the first side of the liquid crystal layer, with the first substrate having a first semiconductor layer. A second substrate is positioned in contact with the second side of the liquid crystal layer, with the second substrate having a second semiconductor transparent electrode layer and a second semiconductor layer. A plurality of laser transparent aperture support st[...]
Our summary: Light valve system with gap maintenance system, includes liquid crystal layer with first and second sides, substrates with semiconductor layers, and laser transparent aperture support structures for stable uniform gap.
light valve system, gap maintenance system, liquid crystal layer, semiconductor layer
Patent
Multiplexed diagnostic assay device
Patent published on the 2025-03-06 in WO under Ref WO2025049225 by ACCESS BIO INC [US] (Choi Young Ho [us], Back Jungho [us], Kim Hyoungsoo [us], Jang Myungkyu [us], Kim Hyeon Suk [us], Lee Ji Yun [us])
Abstract: Diagnostic assay devices for detecting the presence of an analyte in a sample solution may comprise a microreactor configured to form a sample solution containing the analyte, flow the sample solution therethrough in a first direction to form an analyte-capture molecule complex, and transfer the sample solution to an absorbent strip pad configured to flow therethrough, in a second direction crossing the first direction, the sample solution including the analyte-capture molecule complex and indic[...]
Our summary: Microreactor for sample solution, analyte-capture molecule complex formation, absorbent strip pad for detection, bioaerosol sample processing, multiplexed detection of multiple analytes including SARS-Cov2, RSV, influenza A and B.
multiplexed, diagnostic, assay, device
Patent
High-throughput condensate modulator screen
Patent published on the 2025-03-06 in WO under Ref WO2025050003 by TRANSITION BIO INC [US] (Knowles Tuomas Pertti Jonathan [gb], Arora Shilpi [us], Arter William Emrys [gb], Seeber Andrew Ciaran [us], Saar Kadi Liis [ee], Rebmann Marius [gb])
Abstract: The present invention is an ultra-high throughput droplet microfluidics platform that is possible to search through small-molecule chemical space to discover molecules directly through their signatures on protein phase behavior changes. Furthermore, the molecules discovered through this approach are modulators of phase transition characteristics of condensates or of LLPS of target macromolecules. These modulators induce desired functional and/or phenotypical changes, e.g., in cells and living sy[...]
Our summary: Ultra-high throughput droplet microfluidics platform for discovering molecules through protein phase behavior changes, modulators of condensate phase transition characteristics, inducing functional changes in cells, screening phase diagrams for FUS phase separation stabilizers and destabilizers, new approach to drugging biomolecular condensate-dependent pathways.
High-throughput, condensate modulator, droplet microfluidics, phase transition
Patent
Heat dissipation module, heat dissipation device including same, rf module for antenna, antenna device, and lighting device
Patent published on the 2025-03-06 in WO under Ref WO2025048354 by KMW INC [KR] (Kim Duk Yong [kr], Jeong Bae Mook [kr], Yun Min Seon [kr], Choi Oh Seog [kr], Park Min Sik [kr], Ryu Chi Back [kr], Seo Yong Won [kr], Kim Hye Yeon [kr], Choi In Hwa [kr])
Abstract: The present invention relates to a heat dissipation module, a heat dissipation device including same, an RF filter for an antenna, an antenna device, and a lighting device. The heat dissipation module includes a heat conduction panel body having a refrigerant flow space which is a closed space in which a refrigerant is filled and circulates while undergoing phase-change between gas and liquid to emit heat. The refrigerant flow space includes: a first section which is an evaporation area for rece[...]
Our summary: The invention presents a heat dissipation module with a refrigerant flow space for efficient heat dissipation in electronic devices.
heat dissipation module, RF module, antenna device, lighting device
Patent
Interesting, but are these patents really pushing microfluidics forward or just monopolizing ideas and stiferring innovation?
Interesting read, but how about addressing the affordability of microfluidics technology too? Its crucial for wider adoption, dont you think?
Interesting read! But arent we overhyping Microfluidics? Isnt the applicability still limited in real-world scenarios?
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