Latest Publications & Patents on Medical Devices
This is our latest selection of worldwide publications and patents in english on Medical Devices, between many scientific online journals, classified and focused on medical device, catheter, infusion pump, dialysis machine, pacemaker, endoscope, dental implant, insulin pump, CPAP, surgical, oxygen concentrator, contact lense, stethoscope, hearing aid, glucose meter and insulin pen.
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Anti-Adhesion Superhydrophobic High-Frequency Electrotome
Published on 2025-02-22 by Haodong Fu, Yuheng Li, Jiyu Liu, Hao Liu, Yun Li, Yue Zhao, Defeng Yan, Xin Liu @MDPI
Abstract: High-frequency electrotome (HFE) encompassing rapid cutting speed, effective hemostasis, and simple operation plays a critical role in the electrosurgical field. However, the blood and tissue adhesion on HFE can cause secondary tissue tearing and bleeding. Constrained by the blood and tissue adhesion of conventional HFEs during surgical procedure, aside from prolonged surgical time, secondary tissue tear and bleeding may occur. Available methods have been proposed to alleviate these problems, in[...]
Our summary: High-frequency electrotome with anti-adhesion properties for improved surgical outcomes. Reduction of blood and tissue adhesion on SH-HFE through surface patterning. Significant decrease in secondary tissue tearing and bleeding compared to conventional HFEs.
Superhydrophobic, Anti-Adhesion, High-Frequency, Electrotome
Publication
A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep
Published on 2025-02-22 by Amelia R. Tanner, Sarah N. Cilvik, Marjorie A. Nguyen, Evgenia Dobrinskikh, Russell V. Anthony, Stephanie R. Wesolowski, Paul J. Rozance @MDPI
Abstract: Postnatally, glucagon acutely lowers plasma amino acid (AA) concentrations by stimulating hepatic AA catabolism, but its fetal actions remain unclear. This study tested whether a 2 h fetal glucagon infusion would stimulate hepatic AA catabolism and inhibit placental AA transfer. Late-gestation pregnant sheep (0.9 gestation) underwent surgical, vascular catheterization and received fetal glucagon (n = 8) or vehicle infusions (n = 8) in a crossover design with a 48 h washout period. Nutrient uptak[...]
Our summary: Fetal glucagon infusion stimulates hepatic amino acid catabolism in fetal sheep, reducing plasma amino acid concentrations and enhancing glucose production.
fetal glucagon, hepatic catabolism, amino acids, placental transfer
Publication
Nephroprotective and Antioxidant Effects of Jatropha dioica Extract Against Ischemia–Reperfusion Injury in Wistar Rats
Published on 2025-02-21 by Diana Raquel Rodríguez-Rodríguez, Oscar Humberto Mendoza-Hernández, Paula Cordero-Pérez, Verónica Mayela Rivas-Galindo, Diana Patricia Moreno-Peña, Ramiro Tijerina-Márquez, Alondra Michelle Garza-Villarreal, Gabriela Alarcón-Galván, Linda Elsa Muñoz-Espinosa, Homero Arturo Zapata-Chavira, Marco Antonio Hernández-Guedea, Guadalupe Yazmín Solis-Cruz, Liliana Torres-González @MDPI
Abstract: Plant extracts with antioxidant activities have shown nephroprotection against IR injury. Jatropha dioica (Jd) possesses antioxidant activity. Our aim was to evaluate the effects of a hydroalcoholic Jd extract against IR injury in Wistar rats. Rats were divided into groups (n = 6): sham (SH); no toxicity (JdTox; 300 mg/kg/day of extract for 7 days); IR (on day 7 [I: 45 min/R: 24 h]); and Jd+IR (same treatment as JdTox; same surgical procedure as IR). AST and LDH were significantly lower in the J[...]
Our summary: Plant extract Jatropha dioica has antioxidant properties and protects against ischemia-reperfusion injury in rats by reducing renal damage and oxidative stress.
antioxidant, nephroprotective, ischemia-reperfusion injury, Jatropha dioica
Publication
Retina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Networks After Optic Nerve Crush in a Rat Model of Surgical Menopause
Published on 2025-02-21 by Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan, Gabriela Sanchez-Rodriguez, Anna E. Silverio, Vien Nguyen, Laszlo Prokai, Andrew J. Feola @MDPI
Abstract: The association between 17β-estradiol (E2) deprivation, seen in menopause, and a risk for developing glaucoma has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), a prodrug of E2 that selectively produces the neuroprotective hormone in the retina, on visual function after optic nerve crush ([...]
Our summary: DHED prodrug rescues visual function after optic nerve crush in rat model of surgical menopause, exogenous E2 supplementation protects against RGC degradation, discovery-driven retina proteomics identifies neurodegenerative proteins.
retina, DHED, optic nerve crush, proteomics
Publication
Cell Migration in Endometriosis Responds to Omentum-Derived Molecular Cues Similar to Ovarian Cancer
Published on 2025-02-20 by Kah Yee Goh, Su Chin Tham, Terence You De Cheng, Ravichandran Nadarajah, Ronald Chin Hong Goh, Shing Lih Wong, Tew Hong Ho, Ghee Kheng Chew, Andy Wei Keat Tan, Hemashree Rajesh, Hong Liang Chua, Tze Tein Yong, Su Ling Yu, Jia Min Kang, Kah Weng Lau, Amos Zhi En Tay, Sangeeta Mantoo, Inny Busmanis, Sung Hock Chew, Timothy Yong Kuei Lim, Wai Loong Wong, Qiu Ju Ng, Junjie Wang, Sun Kuie Tay, Chit Fang Cheok, Darren Wan-Teck Lim, Elaine Hsuen Lim @MDPI
Abstract: Endometriosis is common and poses significant morbidity of lasting impact to young, pre-menopausal women, while ovarian cancer is a lethal gynecologic condition. Both conditions need better treatment. The human omentum is an apron of adipose tissue in the abdominopelvic cavity, the same space in which endometriosis and ovarian cancer manifest. We aim to determine molecular cues emitted by the omentum that aid the trans-coelomic spread of endometriosis and ovarian cancer in the abdomen&nd[...]
Our summary: Human omentum emits molecular cues aiding in trans-coelomic spread of endometriosis and ovarian cancer. Omental conditioned media promotes cell migration in both conditions. HGF, c-MET, and PTTG1 are potential therapeutic targets.
cell migration, omentum-derived molecular cues, endometriosis, ovarian cancer
Publication
Do They Represent a Reliable Alternative to Current Prosthetic Devices?
Published on 2025-02-20 by Martina Todesco, Gianluca Lezziero, Gino Gerosa, Andrea Bagno @MDPI
Abstract: With the increasing number of people suffering from heart valve diseases (e.g., stenosis and/or insufficiency), the attention paid to prosthetic heart valves has grown significantly. Developing a prosthetic device that fully replaces the functionality of the native valve remains a huge challenge. Polymeric heart valves (PHVs) represent an appealing option, offering the potential to combine the robustness of mechanical valves with the enhanced biocompatibility of bioprosthetic ones. Over the year[...]
Our summary: With the increasing prevalence of heart valve diseases, polymeric heart valves (PHVs) are being explored as a reliable alternative to current prosthetic devices. This comprehensive overview discusses the evolution of PHVs in terms of materials, design, and fabrication techniques, highlighting their potential benefits and drawbacks. Future directions for further development, particularly in transcatheter applications, are also addressed.
polymeric heart valves, biomaterials, fabrication techniques, transcatheter application
Publication
Applying energy to an electrosurgical instrument
Patent published on the 2025-02-19 in GB under Ref GB2632769 by CMR SURGICAL LTD [GB] (David William Haydn Webster-smith [gb], Dominic Martin Mcbrien [gb], Jonathan Peter Waite [gb])
Abstract: A control system 503 for controlling the application of energy from an electrosurgical generator 506 to a robotic electrosurgical instrument 300 during a cut mode in which the electrosurgical instrument is used to cut tissue. The system configured to control the electrosurgical generator to apply energy to the electrosurgical instrument during a first cut phase; detecting a trigger condition has been met during the first cut phase. Wherein the trigger condition comprises one or both of the curre[...]
Our summary: System for controlling energy application to electrosurgical instrument during cut mode, triggering phase change based on current and voltage thresholds, switching to second cut phase after predetermined time.
electrosurgical instrument, control system, energy application, trigger condition
Patent
Debris removal system with automated clearance of lumen obstructions
Patent published on the 2025-02-19 in EP under Ref EP4509071 by BOSTON SCIENT SCIMED INC [US] (Pereira Peter J [us], Phelan Martin [us], Lai Vincent [us])
Abstract: A debris removal system includes an elongated shaft extending from a proximal end to a distal end and including a shaft lumen, the shaft being configured to be inserted through a bodily lumen to a target surgical site, a vibration motor coupled to the elongated shaft via a vibration collar, the vibration motor including a rotatable shaft and at least one weight coupled to the rotatable shaft, the weight being asymmetrically shaped about a central axis of the shaft such that rotation of the shaft[...]
Our summary: Debris removal system with automated clearance of lumen obstructions using a vibration motor and vacuum pump.
debris removal system, automated clearance, lumen obstructions, vibration motor
Patent
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